Biocompatible and biodegradable Bletilla striata polysaccharides hydrogels crosslinked by BDDE for wound healing through the regulating of macrophage polarization

Qiu, Mengyu; Zhong, Guofeng; Zhang, Junbo; Hou, Yusen; Duan, Yun; Guo, Peng; Jiang, Fuchen; Gou, Kaijun; Zhang, Chen; Qu, Yan

doi:10.1016/j.ijbiomac.2023.128015

Cited by 12 publications

(4 citation statements)

References 45 publications

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“…This structure enables HD to quickly absorb liquid, cross-linking with other components in blood or tissue fluid, and display unique mechanical and adhesive properties . The cross-linking reaction used to synthesize hydrogels does not affect the inherent structure and function of natural HD polysaccharide . In HD hydrogels, intermolecular hydrogen bonds and mechanical interlocking of long-chain polymers contribute to maintaining a tunable network microstructure, providing the hydrogel with self-healing capabilities and mechanical stability on a larger scale …”

Section: Results and Discussionmentioning

confidence: 99%

“…HD hydrogels are synthesized by cross-linking HD and the epoxy cross-linking agent PEGDE in alkaline conditions, with any residual unreacted PEGDE removed through dialysis washing. This method eliminates the need for further chemical modification of HD, preserving its natural polysaccharide structure and function . Compared to dendrimers, HD does not have significant toxicological concerns associated with cationic dendritic polymers, rapid systemic clearance, and other drawbacks .…”

Section: Results and Discussionmentioning

confidence: 99%

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Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Lu,

Wang,

Kong

et al. 2024

ACS Appl. Mater. Interfaces

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Postoperative peritoneal adhesions are a prevalent clinical issue following abdominal and pelvic surgery, frequently resulting in heightened personal and societal health burdens. Traditional biomedical barriers offer limited benefits because of practical challenges for doctors and their incompatibility with laparoscopic surgery. Hydrogel materials, represented by hyaluronic acid gels, are receiving increasing attention. However, existing antiadhesive gels still have limited effectiveness or carry the risk of complications in clinical applications. Herein, we developed a novel hydrogel using polysaccharide hemoadhican (HD) as the base material and polyethylene glycol diglycidyl ether (PEGDE) as the cross-linking agent. The HD hydrogels exhibit appropriate mechanical properties, injectability, and excellent cytocompatibility. We demonstrate resistance to protein adsorption and L929 fibroblast cell adhesion to the HD hydrogel. The biodegradability and efficacy against peritoneal adhesion are further evaluated in C57BL/6 mice. Our results suggest a potential strategy for antipostoperative tissue adhesion barrier biomaterials.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Lu,

Wang,

Kong

et al. 2024

ACS Appl. Mater. Interfaces

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“…44 For example, He et al 45 demonstrated that BSP promotes wound healing through inhibition of inflammatory cytokine (IL-1β, IL-6, and TNF-α) synthesis and release through the carrageenan-induced mouse paw edema model. Qiu et al 46 developed full-thickness wounds of rat back skin model and proved that the BDDE cross-linked BSP hydrogel could modulate the polarization of M1-type macrophages toward the M2-type and reduce the inflammatory response during the wound-healing phase to promote wound healing.…”

Section: ■ Discussionmentioning

confidence: 99%

Bletilla striata Polysaccharide-Containing Carboxymethyl Cellulose Bilayer Structure Membrane for Prevention of Postoperative Adhesion and Achilles Tendon Repair

Chen,

Chen

et al. 2024

Biomacromolecules

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Postoperative tissue adhesion and poor tendon healing are major clinical problems associated with tendon surgery. To avoid postoperative adhesion and promote tendon healing, we developed and synthesized a membrane to wrap the surgical site after tendon suturing. The bilayer-structured porous membrane comprised an outer layer [1,4-butanediol diglycidyl ether crosslinked with carboxymethyl cellulose (CX)] and an inner layer [1,4butanediol diglycidyl ether cross-linked with Bletilla striata polysaccharides and carboxymethyl cellulose (CXB)]. The morphology, chemical functional groups, and membrane structure were determined. In vitro experiments revealed that the CX/CXB membrane demonstrated good biosafety and biodegradability, promoted tenocyte proliferation and migration, and exhibited low cell attachment and anti-inflammatory effects. Furthermore, in in vivo animal study, the CX/CXB membrane effectively reduced postoperative tendon−peripheral tissue adhesion and improved tendon repair, downregulating inflammatory cytokines in the tendon tissue at the surgical site, which ultimately increased tendon strength by 54% after 4 weeks.

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“…Historically, it has been utilized for its hemostatic, wound healing promotion, and anti-inflammatory properties. 163 D-mannose residues on the BSP backbone play a crucial role in orchestrating the reprograming of macrophages during both inflammatory and proliferative phases. They achieve this by selectively engaging mannose receptors, which in turn promote collagen deposition and facilitate wound healing.…”

Section: Reprograming Of Macrophages By Immunomodulatory Hydrogels Fa...mentioning

confidence: 99%

Immunomodulation in diabetic wounds healing: The intersection of macrophage reprogramming and immunotherapeutic hydrogels

Sun,

Chang,

2024

J Tissue Eng

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Diabetic wound healing presents a significant clinical challenge due to the interplay of systemic metabolic disturbances and local inflammation, which hinder the healing process. Macrophages undergo a phenotypic shift from M1 to M2 during wound healing, a transition pivotal for effective tissue repair. However, in diabetic wounds, the microenvironment disrupts this phenotypic polarization, perpetuating inflammation, and impeding healing. Reprograming macrophages to restore their M2 phenotype offers a potential avenue for modulating the wound immune microenvironment and promoting healing. This review elucidates the mechanisms underlying impaired macrophage polarization toward the M2 phenotype in diabetic wounds and discusses novel strategies, including epigenetic and metabolic interventions, to promote macrophage conversion to M2. Hydrogels, with their hydrated 3D cross-linked structure, closely resemble the physiological extracellular matrix and offer advantageous properties such as biocompatibility, tunability, and versatility. These characteristics make hydrogels promising candidates for developing immunomodulatory materials aimed at addressing diabetic wounds. Understanding the role of hydrogels in immunotherapy, particularly in the context of macrophage reprograming, is essential for the development of advanced wound care solutions. This review also highlights recent advancements in immunotherapeutic hydrogels as a step toward precise and effective treatments for diabetic wounds.

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Biocompatible and biodegradable Bletilla striata polysaccharides hydrogels crosslinked by BDDE for wound healing through the regulating of macrophage polarization

Cited by 12 publications

References 45 publications

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Hemoadhican-Based Bioabsorbable Hydrogel for Preventing Postoperative Adhesions

Bletilla striata Polysaccharide-Containing Carboxymethyl Cellulose Bilayer Structure Membrane for Prevention of Postoperative Adhesion and Achilles Tendon Repair

Immunomodulation in diabetic wounds healing: The intersection of macrophage reprogramming and immunotherapeutic hydrogels

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