Biocompatible Carbon-Coated Magnetic Nanoparticles for Biomedical Applications

Vijayakanth, V.; Vinodhini, V.; Krishnamoorthi, C.

doi:10.1007/978-981-19-7188-4_34

Cited by 1 publication

(2 citation statements)

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“…Trace carbon is not expected to negatively affect biomedical applications, given that studies have explored biocompatible carbon coatings on magnetic nanoparticles. 57,58 Our findings validate the use of FSP for robust and facile production of doped SPIONs with well-defined particle composition and high purity, crucial to controlling the heating performance of SPIONs.…”

Section: Resultssupporting

confidence: 64%

“…Furthermore, TGA analysis revealed that the midsized doped SPIONs exhibited a small weight loss (2–4 wt %; Table S7), likely due to the thermal decomposition of the carbon residues. Trace carbon is not expected to negatively affect biomedical applications, given that studies have explored biocompatible carbon coatings on magnetic nanoparticles. , Our findings validate the use of FSP for robust and facile production of doped SPIONs with well-defined particle composition and high purity, crucial to controlling the heating performance of SPIONs.…”

Section: Resultsmentioning

confidence: 99%

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Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia

Ansari,

Suárez-López,

Thersleff

et al. 2024

ACS Nano

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Magnetic hyperthermia holds significant therapeutic potential, yet its clinical adoption faces challenges. One obstacle is the large-scale synthesis of high-quality superparamagnetic iron oxide nanoparticles (SPIONs) required for inducing hyperthermia. Robust and scalable manufacturing would ensure control over the key quality attributes of SPIONs, and facilitate clinical translation and regulatory approval. Therefore, we implemented a risk-based pharmaceutical quality by design (QbD) approach for SPION production using flame spray pyrolysis (FSP), a scalable technique with excellent batch-to-batch consistency. A design of experiments method enabled precise size control during manufacturing. Subsequent modeling linked the SPION size (6−30 nm) and composition to intrinsic loss power (ILP), a measure of hyperthermia performance. FSP successfully fine-tuned the SPION composition with dopants (Zn, Mn, Mg), at various concentrations. Hyperthermia performance showed a strong nonlinear relationship with SPION size and composition. Moreover, the ILP demonstrated a stronger correlation to coercivity and remanence than to the saturation magnetization of SPIONs. The optimal operating space identified the midsized (15−18 nm) Mn 0.25 Fe 2.75 O 4 as the most promising nanoparticle for hyperthermia. The production of these nanoparticles on a pilot scale showed the feasibility of large-scale manufacturing, and cytotoxicity investigations in multiple cell lines confirmed their biocompatibility. In vitro hyperthermia studies with Caco-2 cells revealed that Mn 0.25 Fe 2.75 O 4 nanoparticles induced 80% greater cell death than undoped SPIONs. The systematic QbD approach developed here incorporates process robustness, scalability, and predictability, thus, supporting the clinical translation of high-performance SPIONs for magnetic hyperthermia.

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Section: Resultssupporting

confidence: 64%

Section: Resultsmentioning

confidence: 99%