Biocompatible chicken bone extracted dahllite/hydroxyapatite/collagen filler based polysulfone membrane for dialysis

Abstract

In the current study, dahllite/hydroxyapatite/collagen filler extracted via calcination of wasted chicken bone was blended with PSf polymer to obtain highly biocompatible, and antifoulant hemodialysis membranes. FTIR and Raman spectroscopic analysis was done to obtain information about the bonding chemistry of the obtained filler. The intermolecular interaction that existed between dahllite/hydroxyapatite/collagen filler and pristine PSf was confirmed by Raman spectroscopic study. The PSf polymer exhibited a sponge-like structure owing to its high thickness and slow exchange with non-solvent in coagulation bath whilst the instantaneous de-mixing course produced finger-like capillaries in dahllite/hydroxyapatite/collagen filler based PSf membranes as exposed by SEM photographs. The presence of different wt. % of filler composition in the PSf matrix improved the mechanical strength as revealed by fatigue analysis. The hydrophilic character improved by 78% while leaching consistency adjusted to 0%–4%. Pure water permeation (PWP) flux improved by nine times. The pore profile improved with the addition of filler as revealed by hydrophilicity experiment, PWP flux, and SEM micrographs. Fouling evaluation results disclosed that filler based membranes showed 36% less adsorption of protein (BSA) solution together with more than 84% flux recovery ratio. The biocompatibility valuation analysis unveiled that membranes composed of filler showed extended prothrombin and thrombin coagulation times, reduced activation of fibrinogen mass, and less adhesion of plasma proteins in comparison with pristine PSf membrane. The adsorption capacity of fabricated membranes for urea and creatinine improved by 31% (in the case of urea) and 34% (in the case of creatinine) in contrast with pristine PSf membrane. The overall results showed that the M-3 membrane was optimized in terms of surface properties, protein adhesion, anticoagulation activity, and adsorption amount of urea and creatinine.

Fabrication and performance evaluation of polymeric membrane using blood compatible hydroxyapatite for artificial kidney application

“…Membrane samples (1.5 cm × 1.5 cm) were first neutralized and then positioned in plastic tubes comprising 1 mL of urea and creatinine solution for a 4 hours period at 37°C. Afterward, samples were taken out and the concentration of the remaining solution was estimated by sending samples to Nawaz Sharif Medical Hospital, Lahore, Pakistan 23 …”

“…Afterward, samples were taken out and the concentration of the remaining solution was estimated by sending samples to Nawaz Sharif Medical Hospital, Lahore, Pakistan. 23…”

Deep eutectic solvent functionalized mesoporous silica SBA-15 based mixed matrix polymeric membranes for mitigation of CO2 (Extended Version)

“…% of DES-SBA filler was poured smoothly and mixed for next 24 hrs. The stirring process is stopped, and scotch bottle is kept static in previous position in order to remove trapped air bubbles, and then membrane solution was spread in the petri-dish ensuring its bottom was flat and left to dry with exterior of petri-dish covered by aluminium foil, having small holes on it, for a period of another 24 hrs [18][19][20]35]. The schematic diagram of MMMs formulation is displayed by Fig.…”

“…The polysulfone is used as polymeric support materials in membranes due to its better strength, high thermal stability, non-corrosiveness and easy process ability [18][19][20]. The efficiency of MMMs depends upon the filler attribute as its agglomeration among each other [21] and its attraction with the polymer are the main concerns [22].…”

Dual Optimized Sulfonated Polyethersulfone and Functionalized Multiwall Carbon Tube Based Composites High Fouling Resistance Membrane for Protein Separation

“…The phase inversion method is commonly used to fabricate the UF membranes sold in the market. Mostly, these membranes are made of hydrophobic/semi-hydrophobic polymers such as polyethersulfone (PES), polyvinylidene fluoride, polypropylene and Polysulfone [ 10 , 11 , 12 , 13 ].…”