Biocompatible chitosan-based composites with properties suitable for hyperthermia therapy

Barra, Ana; Alves, Zélia; Ferreira, N.M.; Martins, Manuel A.; Oliveira, Helena; Ferreira, Liliana P.; Cruz, M.M.; Carvalho, Maria Graça; Neumayer, Sabine M.; Rodriguez, Brian J.; Nunes, Cláudia; Ferreira, Paula

doi:10.1039/c9tb02067e

Cited by 40 publications

(22 citation statements)

References 45 publications

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“…Uses in the biomedical area include Chit nanocomposites with metal and graphene oxides for hyperthermia therapy [22], combination with hydroxyapatite and carbon nanotubes to obtain bone implants with higher osteogenic and mechanical properties [23], and the synthesis of new Chit-based nanosystems for the slow release and protection of bioactive ingredients [24]. The deposition of highly resistant elements in a chitosan matrix for metal corrosion inhibition [25] and the absorption of heavy metals and dye remotion from water and industrial wastes [26,27], are other current applications of Chit-based composites.…”

Section: An Overview Of Chitosan Properties and Methods Of Synthesis mentioning

confidence: 99%

Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

et al. 2021

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The capability of some polymers, such as chitosan, to form low cost gels under mild conditions is of great application interest. Ionotropic gelation of chitosan has been used predominantly for the preparation of gel beads for biomedical application. Only in the last few years has the use of this method been extended to the fabrication of chitosan-based flat structures. Herein, after an initial analysis of the major applications of chitosan flat membranes and films and their usual methods of synthesis, the process of ionotropic gelation of chitosan and some recently proposed novel procedures for the synthesis of flat structures are presented.

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Section: An Overview Of Chitosan Properties and Methods Of Synthesis mentioning

confidence: 99%

Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

et al. 2021

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“…The bionanocomposite films containing 50 wt% rGO showed an electrical conductivity of 0.7 S m −1 and 2.1 × 10 −5 S m −1 , in-plane and through-plane, respectively. CS-based flexible films containing rGO-Fe 3−x O 4 were also suggested for electrically conductive food packaging [ 12 ]. These sustainable bionanocomposites, produced in absence of toxic chemicals, achieved an in-plane electrical conductivity of ~0.016 S m −1 with 50 wt% rGO-Fe 3−x O 4 .…”

Section: Graphene Derivatives-based Biocomposites As Food Packaginmentioning

confidence: 99%

“…These sustainable bionanocomposites, produced in absence of toxic chemicals, achieved an in-plane electrical conductivity of ~0.016 S m −1 with 50 wt% rGO-Fe 3−x O 4 . In both works [ 12 , 170 ], the electrically conductive films also display mechanical properties and antioxidant activity attractive for food packaging applications. However, to the best of the authors knowledge, there are no other reports specifically addressing this issue.…”

Section: Graphene Derivatives-based Biocomposites As Food Packaginmentioning

confidence: 99%

“…However, the rGO with high electrical conductivity is usually prepared using toxic reducing agents that prevent its use for food packaging. On the other hand, the use of nontoxic reducing agents produces rGO with lower electrical conductivity [ 12 , 170 , 190 , 223 , 224 ]. The in-situ reduction of GO into NFC with hydroiodic acid (HI) lead to an in-plane electrical conductivity of 22.22 S m −1 , while the same procedure using ascorbic acid lead to an electrical conductivity of 0.83 S m −1 .…”

Section: Graphene Derivatives-based Biocomposites As Food Packaginmentioning

confidence: 99%

“…Some graphene derivatives, such as reduced graphene oxide (rGO) with radical scavenging capacity, may assign an antioxidant activity to the packaging materials, an extremely important property to enhance foodstuffs’ shelf lives [ 10 ]. An interesting breakthrough introduced through use of graphene derivatives is electrical conductivity, which is advantageous for the development of food packaging materials suitable for their application in pulsed electric field technology (PEF) [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Graphene Derivatives in Biopolymer-Based Composites for Food Packaging Applications

et al. 2020

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This review aims to showcase the current use of graphene derivatives, graphene-based nanomaterials in particular, in biopolymer-based composites for food packaging applications. A brief introduction regarding the valuable attributes of available and emergent bioplastic materials is made so that their contributions to the packaging field can be understood. Furthermore, their drawbacks are also disclosed to highlight the benefits that graphene derivatives can bring to bio-based formulations, from physicochemical to mechanical, barrier, and functional properties as antioxidant activity or electrical conductivity. The reported improvements in biopolymer-based composites carried out by graphene derivatives in the last three years are discussed, pointing to their potential for innovative food packaging applications such as electrically conductive food packaging.

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Magnetic Chitosan Bionanocomposite Films as a Versatile Platform for Biomedical Hyperthermia

Barra,

Wychowaniec,

Winning

et al. 2023

Adv Healthcare Materials

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Responsive magnetic nanomaterials offer significant advantages for innovative therapies, for instance, in cancer treatments that exploit on‐demand delivery on alternating magnetic field (AMF) stimulus. In this work, biocompatible magnetic bionanocomposite films are fabricated from chitosan by film casting with incorporation of magnetite nanoparticles (MNPs) produced by facile one pot synthesis. The influence of synthesis conditions and MNP concentration on the films’ heating efficiency and heat dissipation are evaluated through spatio‐temporal mapping of the surface temperature changes by video‐thermography. The cast films have a thickness below 100 µm, and upon exposure to AMF (663 kHz, 12.8 kA m−1), induce exceptionally strong heating, reaching a maximum temperature increase of 82 °C within 270 s irradiation. Further, it is demonstrated that the films can serve as substrates that supply heat for multiple hyperthermia scenarios, including: i) non‐contact automated heating of cell culture medium, ii) heating of gelatine‐based hydrogels of different shapes, and iii) killing of cancerous melanoma cells. The films are versatile components for non‐contact stimulus with translational potential in multiple biomedical applications.

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Biocompatible chitosan-based composites with properties suitable for hyperthermia therapy

Abstract: Sustainably made, flexible and biocompatible composites, having environmentally friendly compositions and multifunctional capabilities, are promising materials for several emerging biomedical applications.

Cited by 40 publications

References 45 publications

Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

Ionotropic Gelation of Chitosan Flat Structures and Potential Applications

Graphene Derivatives in Biopolymer-Based Composites for Food Packaging Applications

Magnetic Chitosan Bionanocomposite Films as a Versatile Platform for Biomedical Hyperthermia

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