Biocompatible Chitosan Nanobubbles for Ultrasound-Mediated Targeted Delivery of Doxorubicin

Zhou, Xiaoying; Guo, Lu; Shi, Dandan; Duan, Sujuan; Li, Jie

doi:10.1186/s11671-019-2853-x

Cited by 52 publications

(34 citation statements)

References 35 publications

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“…Therefore, there is an urgent need to prepare nanoscale drug-loaded ultrasound contrast agents with high safety and definite efficacy. Ultrasonic response nanobubbles synthesized by chitosan, perfluorohexane and other natural materials in our previous research has been proved to have higher biosafety than other contrast agents in cell experiments (Meng et al, 2019;Zhou et al, 2019). They may have a broad prospect in clinical application.…”

Section: Introductionmentioning

confidence: 94%

Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo

et al. 2020

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2020) Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo, Drug Delivery, 27:1, 469-481, ABSTRACTAs an injectable anticancer drug delivery system, the biological safety of nanocarriers is the most important prerequisite for their clinical application. The objective of our study was to synthesize special ultrasound-responsive highly biocompatible chitosan nanodroplets (BCNDs), observe their spatiotemporally control the delivery of doxorubicin (DOX) in vivo. The experimental results showed that the BCNDs were successfully prepared with high biosafety in vivo and great ultrasound imaging ability. DOX-BCNDs promoted the anticancer effects of DOX in vivo and inhibited the development of tumors. They also reduced the side effects to the heart and kidneys. In conclusion, BCNDs are a new type of smart nanocarrier with high biocompatibility and efficacy have great potential to be used in the clinic. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 94%

Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo

et al. 2020

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“…An ultrasound-responsive chitosan DOX nanobubble system was synthesized to deliver DOX following ultrasound exposure. It was observed that almost twice the amount of DOX was released, compared to the nonultrasound-responsive system [ 204 ]. Ultrasound-responsive, polymeric nanobubbles were constructed to deliver both siRNA and PTX to treat hepatocellular carcinoma [ 205 ].…”

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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“…A study was conducted to synthesize DOX-loaded biocompatible chitosan NBs. Nanobubbles-mediated DOX uptake and apoptosis on Michigan cancer foundation-7 cells were measured with flow cytometry and the results showed it to have excellent drug loading capability and ultrasound enhancement [ 96 ]. A new ultrasound imaging contrast agent was introduced, where the NBs were conjugated to poly (lactic-co-glycolic acid) and carried DOX as a cancer drug.…”

Section: Medical Imagingmentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

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Biocompatible Chitosan Nanobubbles for Ultrasound-Mediated Targeted Delivery of Doxorubicin

Cited by 52 publications

References 35 publications

Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo

Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

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