Biocompatible circuit-breaker chip for thermal management of biomedical microsystems

Luo, Yi; Dahmardeh, Masoud; Takahata, Kenichi

doi:10.1088/0960-1317/25/5/055002

Cited by 16 publications

(12 citation statements)

References 43 publications

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“…MEMS transducers and other microsystems offer a practical path to realizing electro thermally active stents with temperature regulation and controls, which enable their reliable and safe use in endohyperthermia treatments of restenosis [ 44 , 101 ].…”

Section: In-stent Restenosis Treatmentmentioning

confidence: 99%

Health Care Monitoring and Treatment for Coronary Artery Diseases: Challenges and Issues

Alghrairi

Sulaiman

Mutashar

2020

Sensors

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In-stent restenosis concerning the coronary artery refers to the blood clotting-caused re-narrowing of the blocked section of the artery, which is opened using a stent. The failure rate for stents is in the range of 10% to 15%, where they do not remain open, thereby leading to about 40% of the patients with stent implantations requiring repeat procedure within one year, despite increased risk factors and the administration of expensive medicines. Hence, today stent restenosis is a significant cause of deaths globally. Monitoring and treatment matter a lot when it comes to early diagnosis and treatment. A review of the present stent monitoring technology as well as the practical treatment for addressing stent restenosis was conducted. The problems and challenges associated with current stent monitoring technology were illustrated, along with its typical applications. Brief suggestions were given and the progress of stent implants was discussed. It was revealed that prime requisites are needed to achieve good quality implanted stent devices in terms of their size, reliability, etc. This review would positively prompt researchers to augment their efforts towards the expansion of healthcare systems. Lastly, the challenges and concerns associated with nurturing a healthcare system were deliberated with meaningful evaluations.

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Section: In-stent Restenosis Treatmentmentioning

confidence: 99%

Health Care Monitoring and Treatment for Coronary Artery Diseases: Challenges and Issues

Alghrairi

Sulaiman

Mutashar

2020

Sensors

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“…1). The breaker design of this chip is based on its earlier prototype without the integrated on-chip capacitor [24]. The Nitinol structure is designed to have the flat state as the memorized shape, which is restored when temperature of the material is elevated to exceed the threshold level.…”

Section: Working Principle and Device Designmentioning

confidence: 99%

“…2 exhibits an out-of-plane displacement of 174.3 μm at its free end. Further information in modeling and simulation results of the cantilever can be found in [24].…”

Section: Working Principle and Device Designmentioning

confidence: 99%

“…All RF excitations were performed with an identical RF output power of 320 mW. the preceding breaker device coupled with a dummy LC-tank model [24]. The stent temperatures followed the cyclic patterns of the breaker's temperatures, so that stent heating was regulated within a certain temperature range during the excitation, e.g.…”

Section: ) Device Positioned Through Antenna Loop In Airmentioning

confidence: 99%

“…Fabrication results: (a) Circuit-breaker chips placed on a Canadian dime (left) with an optical side view (top) and a scanning-electron-microscope image (right) of the Nitinol cantilever actuator[24] showing its cold-state bent condition; (b) completed active stent device (top) with close-up views of the integrated circuit-breaker chip (left) and the other side of the stent terminal on which the interconnect wire was bonded (right).…”

mentioning

confidence: 99%

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RF-Powered Stent With Integrated Circuit Breaker for Safeguarded Wireless Hyperthermia Treatment

Luo

Chen

Dahmardeh

et al. 2015

J. Microelectromech. Syst.

Self Cite

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This paper presents a wireless, electrothermally active stent with an integrated temperature limiter toward the application to endohyperthermia treatment of restenosis, a major post-stenting complication. A stent-based resonant circuit serves as a frequency selective wireless heater controlled using a tuned radio-frequency (RF) electromagnetic field radiated externally, applying local thermal stress to the stented site to suppress in-stent restenosis. A biocompatible 1.5 × 2 × 0.6-mm 3 chip of micro circuit breaker with an embedded capacitor is developed and integrated with the stent to establish the resonant circuitry with a series-connected micro breaker. A micromachined shapememory-alloy cantilever serves as a thermoresponsive switch in the chip that opens/closes the circuit depending on the stent temperature, automatically preventing the stent from overheating in a fully passive manner. Wireless heating tests of the prototypes deployed into artificial artery using commercial balloon catheters demonstrate the designed function of the circuit breaker, regulating the stent temperature within 50°C-66°C when excited in air at an output RF power of 320 mW, which heats the device to 78°C without the breaker. Their performance in physiological saline is also tested and discussed in detail. The experimental results validate the device concept and approach toward enabling reliable and safeguarded hyperthermia treatment through wireless stents.[2015-0007]

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Multifunctional Materials Strategies for Enhanced Safety of Wireless, Skin‐Interfaced Bioelectronic Devices

Liu

Kim

Yang

et al. 2023

Adv Funct Materials

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Many recently developed classes of wireless, skin‐interfaced bioelectronic devices rely on conventional thermoset silicone elastomer materials, such as poly(dimethylsiloxane) (PDMS), as soft encapsulating structures around collections of electronic components, radio frequency antennas and, commonly, rechargeable batteries. In optimized layouts and device designs, these materials provide attractive features, most prominently in their gentle, noninvasive interfaces to the skin even at regions of high curvature and large natural deformations. Past studies, however, overlook opportunities for developing variants of these materials for multimodal means to enhance the safety of the devices against failure modes that range from mechanical damage to thermal runaway. This study presents a self‐healing PDMS dynamic covalent matrix embedded with chemistries that provide thermochromism, mechanochromism, strain‐adaptive stiffening, and thermal insulation, as a collection of attributes relevant to safety. Demonstrations of this materials system and associated encapsulation strategy involve a wireless, skin‐interfaced device that captures mechanoacoustic signatures of health status. The concepts introduced here can apply immediately to many other related bioelectronic devices.

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Biocompatible circuit-breaker chip for thermal management of biomedical microsystems

Cited by 16 publications

References 43 publications

Health Care Monitoring and Treatment for Coronary Artery Diseases: Challenges and Issues

Health Care Monitoring and Treatment for Coronary Artery Diseases: Challenges and Issues

RF-Powered Stent With Integrated Circuit Breaker for Safeguarded Wireless Hyperthermia Treatment

Multifunctional Materials Strategies for Enhanced Safety of Wireless, Skin‐Interfaced Bioelectronic Devices

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