Biocompatible Customized 3D Bone Scaffolds Treated with CRFP, an Osteogenic Peptide

Mustahsan, Vamiq M.; Anugu, Amith; Komatsu, David E.; Kao, Imin; Pentyala, Srinivas

doi:10.3390/bioengineering8120199

Cited by 7 publications

(4 citation statements)

References 60 publications

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“…Herein lies the significance of this study, which proposes a systematic and standardized evaluation protocol for polyjet materials beyond M610. This protocol has the potential to broaden the scope of possibilities for fabricating components suitable for cell-culture studies, microfluidic setups, and even bone scaffolds [ 38 – 40 ]. By exploring a variety of materials, researchers and clinicians can now assess their compatibility with biological systems, paving the way for more advanced and tailored applications in medical research and practice.…”

Section: Discussionmentioning

confidence: 99%

Medical 3D printing with polyjet technology: effect of material type and printing orientation on printability, surface structure and cytotoxicity

Schneider,

Oberoi,

Unger

et al. 2023

3D Print Med

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Due to its high printing resolution and ability to print multiple materials simultaneously, inkjet technology has found wide application in medicine. However, the biological safety of 3D-printed objects is not always guaranteed due to residues of uncured resins or support materials and must therefore be verified. The aim of this study was to evaluate the quality of standard assessment methods for determining the quality and properties of polyjet-printed scaffolds in terms of their dimensional accuracy, surface topography, and cytotoxic potential.Standardized 3D-printed samples were produced in two printing orientations (horizontal or vertical). Printing accuracy and surface roughness was assessed by size measurements, VR-5200 3D optical profilometer dimensional analysis, and scanning electron microscopy. Cytotoxicity tests were performed with a representative cell line (L929) in a comparative laboratory study. Individual experiments were performed with primary cells from clinically relevant tissues and with a Toxdent cytotoxicity assay.Dimensional measurements of printed discs indicated high print accuracy and reproducibility. Print accuracy was highest when specimens were printed in horizontal direction. In all cytotoxicity tests, the estimated mean cell viability was well above 70% (p < 0.0001) regardless of material and printing direction, confirming the low cytotoxicity of the final 3D-printed objects. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Medical 3D printing with polyjet technology: effect of material type and printing orientation on printability, surface structure and cytotoxicity

Schneider,

Oberoi,

Unger

et al. 2023

3D Print Med

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show abstract

“…For the three cases reported below, PLA was used for printing the anatomical trial models, polymethyl methacrylate (PMMA) for printing the definitive personalized implants (on the biocompatibility of PMMA can be consulted, for example, [9][10][11][12]), and PolyJet photopolymer (MED610), which biocompatibility allows prolonged contact of up to 30 days with the skin and up to 24 hours with the mucous membranes, for the manufacture of cutting guides (on the biocompatibility and other properties of MED610 can be consulted, for example, [13][14][15]).…”

Section: Case Examplesmentioning

confidence: 99%

Application of a comprehensive methodology for the development of personalized bone implants: exemplification through three cases

Torres-Jara,

Vázquez-Silva,

Moncayo-Matute

et al. 2023

J. Phys.: Conf. Ser.

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This work presents a compilation, through three real cases, on the application of a comprehensive methodology that describes the processes and materials that can be used for the design and manufacture of personalized bone implants and surgical planning. To do this, doctors and engineers generate test anatomical models to study and simulate the operative approach, surgical cutting guides to reduce the time of the intervention, and the bone implant itself to correct or overcome certain pathologies. In all the cases treated, the physical and mechanical properties of the structure, bone or not, replaced or studied, have been taken into account.

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“…Currently, there are various new technologies and devices that assist in clinical diagnostic work [12,24,8], among which medical image segmentation plays an important role in clinical auxiliary diagnosis [44]. Recently, researchers have made great efforts in medical image segmentation [31,53,11] and achieved excellent performance with a large amount of labeled data.…”

Section: Introductionmentioning

confidence: 99%

Semi-Supervised Medical Image Segmentation with Co-Distribution Alignment

Wang

Huang

et al. 2023

Bioengineering

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Medical image segmentation has made significant progress when a large amount of labeled data are available. However, annotating medical image segmentation datasets is expensive due to the requirement of professional skills. Additionally, classes are often unevenly distributed in medical images, which severely affects the classification performance on minority classes. To address these problems, this paper proposes Co-Distribution Alignment (Co-DA) for semi-supervised medical image segmentation. Specifically, Co-DA aligns marginal predictions on unlabeled data to marginal predictions on labeled data in a class-wise manner with two differently initialized models before using the pseudo-labels generated by one model to supervise the other. Besides, we design an over-expectation cross-entropy loss for filtering the unlabeled pixels to reduce noise in their pseudo-labels. Quantitative and qualitative experiments on three public datasets demonstrate that the proposed approach outperforms existing state-of-the-art semi-supervised medical image segmentation methods on both the 2D CaDIS dataset and the 3D LGE-MRI and ACDC datasets, achieving an mIoU of 0.8515 with only 24% labeled data on CaDIS, and a Dice score of 0.8824 and 0.8773 with only 20% data on LGE-MRI and ACDC, respectively.

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Biocompatible Customized 3D Bone Scaffolds Treated with CRFP, an Osteogenic Peptide

Cited by 7 publications

References 60 publications

Medical 3D printing with polyjet technology: effect of material type and printing orientation on printability, surface structure and cytotoxicity

Medical 3D printing with polyjet technology: effect of material type and printing orientation on printability, surface structure and cytotoxicity

Application of a comprehensive methodology for the development of personalized bone implants: exemplification through three cases

Semi-Supervised Medical Image Segmentation with Co-Distribution Alignment

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