Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high <i>T</i><sub>1</sub> relaxivity and selective cytotoxicity to cancer cells

Попов, А. И.; Abakumov, Maxim A.; Savintseva, I. V.; Ермаков, А. М.; Popova, Nelli R.; Иванова, О. С.; Kolmanovich, D. D.; Baranchikov, А. Е.; Иванов, В. К.

doi:10.1039/d1tb01147b

Cited by 32 publications

(26 citation statements)

References 90 publications

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“…Nuclear medicine imaging has the highest sensitivity (pM range) and quantitative property, but suffers from a poor spatial resolution (mm range) [ 170 ]; CT excels at rapid image acquisition and facile three-dimensional (3D) reconstruction, but has limited resolution in soft tissues [ 171 ]; MRI has a high spatial resolution and excellent soft-tissue contrast with the versatility to provide information regarding tissue metabolism and perfusion. However, MRI suffers from lower sensitivity and hence requires a higher contrast agent dose to achieve necessary resolution [ 172 ], although recent advances in nanotheranostics have enhanced the per particle and per metal ion relaxivity [ 173 , 174 ]. It is also challenging to perform whole-body assessment using MRI and US, and therefore it is foreseeable nuclear imaging will remain as the quantitative whole-body approach in the near future.…”

Section: Discussionmentioning

confidence: 99%

Nanotheranostics for Image-Guided Cancer Treatment

et al. 2022

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Image-guided nanotheranostics have the potential to represent a new paradigm in the treatment of cancer. Recent developments in modern imaging and nanoparticle design offer an answer to many of the issues associated with conventional chemotherapy, including their indiscriminate side effects and susceptibility to drug resistance. Imaging is one of the tools best poised to enable tailoring of cancer therapies. The field of image-guided nanotheranostics has the potential to harness the precision of modern imaging techniques and use this to direct, dictate, and follow site-specific drug delivery, all of which can be used to further tailor cancer therapies on both the individual and population level. The use of image-guided drug delivery has exploded in preclinical and clinical trials although the clinical translation is incipient. This review will focus on traditional mechanisms of targeted drug delivery in cancer, including the use of molecular targeting, as well as the foundations of designing nanotheranostics, with a focus on current clinical applications of nanotheranostics in cancer. A variety of specially engineered and targeted drug carriers, along with strategies of labeling nanoparticles to endow detectability in different imaging modalities will be reviewed. It will also introduce newer concepts of image-guided drug delivery, which may circumvent many of the issues seen with other techniques. Finally, we will review the current barriers to clinical translation of image-guided nanotheranostics and how these may be overcome.

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Section: Discussionmentioning

confidence: 99%

Nanotheranostics for Image-Guided Cancer Treatment

et al. 2022

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“…They are quite promising as they are effectively endocytosed by normal and cancerous human cells. As well, they demonstrate dose‐dependent selective cytotoxicity to cancerous cells 68 …”

Section: Future Perspectivesmentioning

confidence: 96%

“…As well, they demonstrate dose-dependent selective cytotoxicity to cancerous cells. 68 Specific targeting of CeO 2 NPs to the diseased tissue could also enhance the therapeutic activity and improve the pharmacokinetics of the NPs. A recent research has revealed that active targeting accomplished by the decoration of hyaluronic acid on the surface of CePEI-NPs resulted in significant increase in breast cancer cell uptake.…”

Section: Future Perspectivesmentioning

confidence: 99%

The use of cerium oxide nanoparticles in liver disorders: A double‐sided coin?

Attia

Rostom

Mashal

2022

Basic Clin Pharma Tox

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Being recognized as the first antioxidant nanoparticles (NPs) proposed for medicine, cerium oxide NPs (CeO2NPs) have recently gained tremendous attention for their vast biomedical applications. Nevertheless, inconsistent reports of either medical benefits or toxicity have created an atmosphere of uncertainty hindering their clinical utilization. Like other NPs advocated as a promising protective/therapeutic option, CeO2NPs are sometimes questioned as a health threat. As CeO2NPs tend to accumulate in the liver after intravenous injection, liver is known to represent the key tissue to test for their therapeutic/toxicological effects. However, more research evidence is still needed before any conclusions can be elicited about the mechanisms by which CeO2NPs could be harmful or protective/therapeutic to the liver tissue. A proper understanding of such discrepancies is warranted to plan for further modifications to mitigate any side effects. Therefore, in this MiniReview, we tried to demonstrate the two sides of the same coin, CeO2NPs, within the liver context. As well, we highlighted a few promising strategies by which the negatives of CeO2NPs could be diminished while enhancing all the positives.

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“…In the authors’ previous studies, a proposal was made for the design of new Gd-based MRI contrast agents based on nanocrystalline Gd-doped ceria [ 6 , 7 , 8 , 9 ]. In an oxide matrix, Gd 3+ ions can provide higher values of longitudinal relaxation constants than Gd 3+ in chelate complexes.…”

Section: Introductionmentioning

confidence: 99%

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

et al. 2023

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Recently, human mesenchymal stem cells (hMSc) have attracted a great deal of attention as potential therapeutic agents in the treatment of socially significant diseases. Despite substantial advances in stem-cell therapy, the biological mechanisms of hMSc action after transplantation remain unclear. The use of magnetic resonance imaging (MRI) as a non-invasive method for tracking stem cells in the body is very important for analysing their distribution in tissues and organs, as well as for ensuring control of their lifetime after injection. Herein, detailed experimental data are reported on the biocompatibility towards hMSc of heavily gadolinium-doped cerium oxide nanoparticles (Ce0.8Gd0.2O2−х) synthesised using two synthetic protocols. The relaxivity of the nanoparticles was measured in a magnetic field range from 1 mT to 16.4 T. The relaxivity values (r1 = 11 ± 1.2 mM−1 s−1 and r1 = 7 ± 1.2 mM−1 s−1 in magnetic fields typical of 1.5 and 3 T MRI scanners, respectively) are considerably higher than those of the commercial Omniscan MRI contrast agent. The low toxicity of gadolinium-doped ceria nanoparticles to hMSc enables their use as an effective theranostic tool with improved MRI-contrasting properties.

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Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T₁ relaxivity and selective cytotoxicity to cancer cells

Abstract: Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

Cited by 32 publications

References 90 publications

Nanotheranostics for Image-Guided Cancer Treatment

Nanotheranostics for Image-Guided Cancer Treatment

The use of cerium oxide nanoparticles in liver disorders: A double‐sided coin?

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

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Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T1 relaxivity and selective cytotoxicity to cancer cells

Abstract: Gd-based complexes are widely used as magnetic resonance imaging (MRI) contrast agents. The safety of previously approved contrast agents is questionable and is being re-assessed. The main causes of concern...

Cited by 32 publications

References 90 publications

Nanotheranostics for Image-Guided Cancer Treatment

Nanotheranostics for Image-Guided Cancer Treatment

The use of cerium oxide nanoparticles in liver disorders: A double‐sided coin?

Heavily Gd-Doped Non-Toxic Cerium Oxide Nanoparticles for MRI Labelling of Stem Cells

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Product

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Biocompatible dextran-coated gadolinium-doped cerium oxide nanoparticles as MRI contrast agents with high T₁ relaxivity and selective cytotoxicity to cancer cells