Biocompatible Ferrofluid‐Based Millirobot for Tumor Photothermal Therapy in Near‐Infrared‐II Window

Ji, Yiming; Bai, Xue; Sun, Hongyan; Wang, Luyao; Gan, Chunyuan; Jia, Lina; Xu, Junjie; Zhang, Wei; Wang, Liang; Xu, Yingchen; Hou, Yaxin; Wang, Yinyan; Hui, Hui; Feng, Lin

doi:10.1002/adhm.202302395

Cited by 5 publications

(1 citation statement)

References 69 publications

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“…The coprecipitation method is used for synthesizing Fe 3 O 4 nanoparticles coated with oleic acid ( 49 – 51 ). Subsequently, these nanoparticles are incorporated into mineral oil, resulting in the formation of an oil-based ferrofluid (please refer to Materials and Methods and fig.…”

Section: Resultsmentioning

confidence: 99%

Individual and collective manipulation of multifunctional bimodal droplets in three dimensions

Sun,

Park

et al. 2024

Sci. Adv.

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Spatiotemporally controllable droplet manipulation is vital across numerous applications, particularly in miniature droplet robots known for their exceptional deformability. Despite notable advancements, current droplet control methods are predominantly limited to two-dimensional (2D) deformation and motion of an individual droplet, with minimal exploration of 3D manipulation and collective droplet behaviors. Here, we introduce a bimodal actuation strategy, merging magnetic and optical fields, for remote and programmable 3D guidance of individual ferrofluidic droplets and droplet collectives. The magnetic field induces a magnetic dipole force, prompting the formation of droplet collectives. Simultaneously, the optical field triggers isothermal changes in interfacial tension through Marangoni flows, enhancing buoyancy and facilitating 3D movements of individual and collective droplets. Moreover, these droplets can function autonomously as soft robots, capable of transporting objects. Alternatively, when combined with a hydrogel shell, they assemble into jellyfish-like robots, driven by sunlight. These findings present an efficient strategy for droplet manipulation, broadening the capabilities of droplet-based robotics.

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Section: Resultsmentioning

confidence: 99%

Individual and collective manipulation of multifunctional bimodal droplets in three dimensions

Sun,

Park

et al. 2024

Sci. Adv.

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Micro‐ and nanorobots from magnetic particles: Fabrication, control, and applications

Wang,

Yang,

2024

Responsive Materials

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Magnetic microparticles (MPs) and nanoparticles (NPs) have long been used as ideal miniaturized delivery and detection platforms. Their use as micro‐ and nanorobots (MNRs) is also emerging in the recent years with the help of more dedicated external magnetic field manipulations. In this review, we summarize the research progress on magnetic micro‐ and nanoparticle (MNP)‐based MNRs. First, the fabrication of micro‐ and nanorobots from either template‐assisted NP doping methods or directly synthesized MPs is summarized. The external driving torque sources for both types of MNRs are analyzed, and their propulsion control under low Reynolds number flows is discussed by evaluating symmetry breaking mechanisms and interparticle interactions. Subsequently, the use of these MNRs as scientific models, bioimaging agents, active delivery, and treatment platforms (drug and cell delivery, and sterilization), and biomedical diagnostics has also been reviewed. Finally, the perspective of MNPs‐based MNRs was outlined, including challenges and future directions.

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Dual Responsive Magnetic DCR3 Nanoparticles: A New Strategy for Efficiently Targeting Hepatocellular Carcinoma

Jia,

Dai,

et al. 2024

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Hepatocellular carcinoma (HCC) is a major cause of cancer deaths globally. Unlike traditional molecularly targeted drugs, magnetically controlled drug delivery to micro/nanorobots enhances precision in targeting tumors, improving drug efficiency and minimizing side effects. This study develops a dual‐responsive, magnetically controlled drug delivery system using PEGylated paramagnetic nanoparticles conjugated with decoy receptor 3 (DCR3) antibodies. The clusters demonstrate capabilities for long‐range, magnetically driven control and molecular chemotaxis. Paramagnetic PEGylated particles form vortex‐ and liquid‐like drug moieties within a magnetically controlled system. Vortex‐like nanoparticle clusters exhibit high controllability and countercurrent movement, while liquid‐nanoparticle robot clusters display greater deformability. Upon loading with DCR3 antibodies, the particles navigate along DCR3‐protein gradients in blood and tissue, effectively targeting liver tumor sites in vivo. Clusters of DCR3‐coupled magnetic nanoparticles target cells that highly express DCR3, thereby effectively inhibiting tumor cell proliferation and migration. Compared with conventional nanomedicine, DCR3‐coupled magnetic nanoparticle clusters are capable of delivering controlled drugs over long distances and responding in a molecular‐targeting manner. This research is expected to significantly impact the field of precise tumor drug delivery.

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Biocompatible Ferrofluid‐Based Millirobot for Tumor Photothermal Therapy in Near‐Infrared‐II Window

Cited by 5 publications

References 69 publications

Individual and collective manipulation of multifunctional bimodal droplets in three dimensions

Individual and collective manipulation of multifunctional bimodal droplets in three dimensions

Micro‐ and nanorobots from magnetic particles: Fabrication, control, and applications

Dual Responsive Magnetic DCR3 Nanoparticles: A New Strategy for Efficiently Targeting Hepatocellular Carcinoma

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