Biocompatible gadolinium-coated magnesium alloy for biomedical applications

Saranya, K.; Srinivasan, Badrinarayanan; Chatterjee, Suvro; Rajendran, N.

doi:10.1007/s10853-020-04742-z

Cited by 37 publications

(15 citation statements)

References 35 publications

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“…Similar results for the presence of MgF 2 and MgO were described for pure magnesium with an MAO coating by Gan et al [37]. Additionally, in another article, XPS results indicated the presence of MgF 2 and MgO for the formed gadolinium oxide coating on pure magnesium [39]. The results of open-circuit potential (E OCP ), corrosion potential (E corr ), anodic and cathodic Tafel slopes (β a , β c ), polarization resistance (R p ) and corrosion current density (j corr ) are presented in Table 4.…”

Section: Xps Analysissupporting

confidence: 81%

“…For the MgCa 4.5 Gd 0.5 sample, the oxygen line may have partly overlapped with Gd 2 O 3 and, therefore, the percentage contribution of the low BE line increased (by 13.44%) compared to the MgCa alloy (by 8.56%). The presence of Gd 2 O 3 is also indicated by the XPS results of the formation of the gadolinium oxide layer on the magnesium alloy substrate [ 39 ]. The influence of the adsorbed Mg(OH) 2 on O1s line in both studied specimens (especially in higher BE) may also be relevant.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Moreover, the influence of Gd addition into magnesium alloys resulting in improved corrosion resistance was described by Chen et al [ 47 ]. Additionally, according to [ 39 ], the corrosion susceptibility of alloys with lower Gd content probably resulted from a larger volume of the CaMg 2 phase. Moreover, on the uncoated Mg-Ca-Gd alloys, the passive layer formed is more stable (compared to the MgCa alloys alone).…”

Section: Resultsmentioning

confidence: 99%

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Surface Modification of Biomedical MgCa4.5 and MgCa4.5Gd0.5 Alloys by Micro-Arc Oxidation

et al. 2021

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The aim of this work was to characterize the structure and corrosion properties of the MgCa4.5(Gd0.5) alloys surface treated by the micro-arc oxidation (MAO) process. The MgCa4.5 and MgCa4.5Gd0.5 alloy samples were processed by MAO in an electrolyte composed of NaOH (10 g/dm3), NaF (10 g/dm3), NaH2PO4 (5 g/dm3), Na2SiO2·5H2O (10 g/dm3) and water. Two different voltages (120 V and 140 V) were used in the MAO process. The alloys protected by an oxide layer formed in the MAO were then the subject of corrosion resistance tests in an environment simulating the human body (Ringer’s solution). After the experiments, the resulting samples were investigated with using SEM, XPS and EDS techniques. The addition of Gd affected the fragmentation of the coating structure, thereby increasing the specific surface; higher voltages during the MAO process increased the number and size of surface pores. Corrosion tests showed that the MgCa4.5Gd0.5 alloys were characterized by low polarization resistances and high corrosion current densities. The studies indicated the disadvantageous influence of gadolinium on the corrosion resistance of MgCa4.5 alloys. The immersion tests confirmed lower corrosion resistance of MgCa4.5Gd0.5 alloys compared to the referenced MgCa4.5 ones. The MgCa4.5 alloy with the MAO coating established at voltage 140 V demonstrated the best anticorrosion properties.

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Section: Xps Analysissupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Surface Modification of Biomedical MgCa4.5 and MgCa4.5Gd0.5 Alloys by Micro-Arc Oxidation

et al. 2021

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“…The corrosion current densities ( i corr ) and corrosion potentials ( E corr ) were directly derived from linear polarization curves by Tafel extrapolation. The corrosion rate and polarization resistance were determined by using the Stern–Geary equation where β a and β c are slopes of the anodic and cathodic parts of the polarization plots; R p is polarization resistance.…”

Section: Methodsmentioning

confidence: 99%

Anticancer Activity of Samarium-Coated Magnesium Implants for Immunocompromised Patients

Kannan

Rajendran

2020

ACS Appl. Bio Mater.

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The removal of tumors in the osseous tissue leads to functional disorders. To overcome this issue, biodegradable implants are used to replace the damaged part of the system. In the study, samarium oxide was coated on the anodic layer of AZ31 magnesium alloy. The potentiodynamic polarization, electrochemical impedance, and localized electrochemical impedance spectroscopy studies were carried out for the samarium-coated magnesium alloy. The corrosion resistance of the coating improved several folds than the bare alloy. The apatite formed on the 3rd day of immersion in the simulated body fluid showed cuboid and triangular structures, whereas on the 7th day, it exhibited a sea sponge-like appearance. The coating exhibited inherent anticancer and antibacterial properties. Our work suggests that the samarium coating is expected to be a promising orthopedic implant for preventing tumor relapse and metastasis.

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Citrate Improves Biomimetic Mineralization Induced by Polyelectrolyte–Cation Complexes Using PAsp‐Ca&Mg Complexes

Shen,

Xu,

et al. 2024

Adv Healthcare Materials

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Magnesium ions are highly enriched in early stage of biological mineralization of hard tissues. Paradoxically, hydroxyapatite (HAp) crystallization is inhibited significantly by high concentration of magnesium ions. The mechanism to regulate magnesium‐doped biomimetic mineralization of collagen fibrils has never been fully elucidated. Herein, we revealed that citrate could bio‐inspire the magnesium‐stabilized mineral precursors to generate magnesium‐doped biomimetic mineralization as follows: Citrate could enhance the electronegativity of collagen fibrils by its absorption to fibrils via hydrogen bonds. Afterward, electronegative collagen fibrils could attract highly‐concentrated electropositive polyaspartic acid‐Ca&Mg (PAsp‐Ca&Mg) complexes followed by phosphate solution via strong electrostatic attraction. In the meanwhile, citrate adsorbed in/on fibrils could eliminate mineralization inhibitory effects of magnesium ions by breaking hydration layer surrounding magnesium ions and thus reduce dehydration energy barrier for rapid fulfillment of biomimetic mineralization. The remineralized demineralized dentin with magnesium‐doped HAp possessed antibacterial ability and the mineralization mediums possessed excellent biocompatibility via cytotoxicity and oral mucosa irritation tests. This strategy should shed light on cationic ions‐doped biomimetic mineralization with antibacterial ability via modifying collagen fibrils and eliminating mineralization inhibitory effects of some cationic ions, as well as could excite attention to the neglected multiple regulations of small biomolecules, such as citrate, during biomineralization process.This article is protected by copyright. All rights reserved

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Biocompatible gadolinium-coated magnesium alloy for biomedical applications

Cited by 37 publications

References 35 publications

Surface Modification of Biomedical MgCa4.5 and MgCa4.5Gd0.5 Alloys by Micro-Arc Oxidation

Surface Modification of Biomedical MgCa4.5 and MgCa4.5Gd0.5 Alloys by Micro-Arc Oxidation

Anticancer Activity of Samarium-Coated Magnesium Implants for Immunocompromised Patients

Citrate Improves Biomimetic Mineralization Induced by Polyelectrolyte–Cation Complexes Using PAsp‐Ca&Mg Complexes

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