Biocompatible Hydrogels Based on Food Gums with Tunable Physicochemical Properties as Scaffolds for Cell Culture

Abstract

Hydrogels composed of food gums have gained attention for future biomedical applications, such as targeted delivery and tissue engineering. For their translation to clinical utilization, reliable biocompatibility, sufficient mechanical performance, and tunable structure of polysaccharide hydrogels are required aspects. In this work, we report a unique hybrid polysaccharide hydrogel composed of salecan and curdlan, in which the former is a thickening agent and the latter serves as a network matrix. The physicochemical properties, such as mechanical strength, thermal stability, swelling, and morphology, of the developed composite hydrogel can be accurately modulated by varying the polysaccharide content. Importantly, cytotoxicity assays show the non-toxicity of this hybrid hydrogel. Furthermore, this hydrogel system can support cell proliferation, migration, and function. Altogether, our work proposes a new strategy to build a polysaccharide-constructed hydrogel scaffold, which holds much promise for tissue engineering in terms of cell engraftment, survival, proliferation, and function.

A biocompatible hydrogel as a template for oxidative decomposition reactions: a chemodosimetric analysis and in vitro imaging of hypochlorite

“…Bio-responsive supramolecular hydrogels derived from biocompatible low-molecular weight amphiphiles have recently emerged as advanced photo-responsive materials, due to their applications in cell imaging, tissue engineering, biosensing and drug delivery. 1–10 Fluorescent hydrogels composed of naturally occurring hydrophobic amino acid residues are of particular interest, since they can form 3D-chiral nanostructures depending upon the H-bonding and π-stacking ability of the side-chain residues. 11–22 On the other hand, as a signalling moiety, pyrene remains as the fluorophore of choice due to its excellent photostability, high quantum yield and ability to undergo monomer to excimer transformation depending upon the microenvironment.…”

Recent advances in polysaccharide‐based hydrogels for synthesis and applications

“…Recently, with the development of biological applications of flexible materials and environmental concerns, biological hydrogels created using natural resources (e.g., cellulose, alginate, chitosan, and cyclodextrins [CDs]; Figure 1) have been extensively exploited as alternative renewable materials to alleviate the increasing global energy crisis. [10][11][12][13] These materials can be classified as polysaccharide biomass resources consisting of monosaccharides repeating units. [14,15] They play a crucial role in supplying energy for living organisms and can be readily found in plants, animals, or microbial worlds.…”

A Bio-Based Hydrogel Derived from Moldy Steamed Bread as Urea-Formaldehyde Loading for Slow-Release and Water-Retention Fertilizers

“…Waste starch is a biocompatible, biodegradable, nontoxic, renewable, and sustainable low-cost polysaccharide. 13 Moldy steamed bread, the primary composition of food waste, contains various hydrophilic functional groups and can be used in the preparation of SAPs. 13 Therefore, recycling the waste starch into a SAP could not only reduce its costs and improve its biodegradation properties but also supply a new platform for reusing kitchen waste.…”

“…However, most of the commercial SAPs are petroleum-based materials of high production cost and poor biodegradability, which restricts their application in agriculture. Waste starch is a biocompatible, biodegradable, nontoxic, renewable, and sustainable low-cost polysaccharide . Moldy steamed bread, the primary composition of food waste, contains various hydrophilic functional groups and can be used in the preparation of SAPs .…”