Biocompatible hydroxyapatite ceramic coating on titanium alloys by electrochemical methods via Growing Integration Layers [GIL] strategy: A review

Huang, Chi-Huang; Yoshimura, Masahiro

doi:10.1016/j.ceramint.2022.12.248

Cited by 14 publications

(4 citation statements)

References 64 publications

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“…Osteoblast-like cell adhesion was also found to be more pronounced on rougher substrates, while fibroblasts showed a preference for smoother surfaces [43]. In multiple in vivo experiments, rough surfaces were associated with enhanced bone growth and improved fixation compared to their smoother counterparts [44].…”

Section: Bone-hydroxyapatite Coated Implant Interfacementioning

confidence: 92%

Titanium Implants Coated with Hydroxyapatite Used in Orbital Wall Reconstruction—A Literature Review

Vasile,

Pirvulescu,

Iancu

et al. 2024

Materials

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With the increasing incidences of orbital wall injuries, effective reconstruction materials and techniques are imperative for optimal clinical outcomes. In this literature review, we delve into the efficacy and potential advantages of using titanium implants coated with nanostructured hydroxyapatite for the reconstruction of the orbital wall. Titanium implants, recognized for their durability and mechanical strength, when combined with the osteoconductive properties of hydroxyapatite, present a potentially synergistic solution. The purpose of this review was to critically analyze the recent literature and present the state of the art in orbital wall reconstruction using titanium implants coated with nanostructured hydroxyapatite. This review offers clinicians detailed insight into the benefits and potential drawbacks of using titanium implants coated with nanostructured hydroxyapatite for orbital wall reconstruction. The highlighted results advocate for its benefits in terms of osseointegration and provide a novel strategy for orbital reconstruction, though further studies are essential to establish long-term efficacy and address concerns.

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Section: Bone-hydroxyapatite Coated Implant Interfacementioning

confidence: 92%

Titanium Implants Coated with Hydroxyapatite Used in Orbital Wall Reconstruction—A Literature Review

Vasile,

Pirvulescu,

Iancu

et al. 2024

Materials

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“…It is also known that the presence of hydrated silica [378], sodium ions [379] or both (i.e., sodium silicate) [380] has a positive effect on CaPO 4 precipitation onto substrates. Additional details on this topic can be found in the literature [32,[381][382][383], among which the newly growing integrated layer strategy [383] is outlined.…”

Section: Wet Techniquesmentioning

confidence: 99%

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Dorozhkin

2023

J. Compos. Sci.

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A The present overview describes various production techniques for biocompatible calcium orthophosphate (abbreviated as CaPO4) deposits (coatings, films and layers) on the surfaces of various types of substrates to impart the biocompatible properties for artificial bone grafts. Since, after being implanted, the grafts always interact with the surrounding biological tissues at the interfaces, their surface properties are considered critical to clinical success. Due to the limited number of materials that can be tolerated in vivo, a new specialty of surface engineering has been developed to desirably modify any unacceptable material surface characteristics while maintaining the useful bulk performance. In 1975, the development of this approach led to the emergence of a special class of artificial bone grafts, in which various mechanically stable (and thus suitable for load-bearing applications) implantable biomaterials and artificial devices were coated with CaPO4. Since then, more than 7500 papers have been published on this subject and more than 500 new publications are added annually. In this review, a comprehensive analysis of the available literature has been performed with the main goal of finding as many deposition techniques as possible and more than 60 methods (double that if all known modifications are counted) for producing CaPO4 deposits on various substrates have been systematically described. Thus, besides the introduction, general knowledge and terminology, this review consists of two unequal parts. The first (bigger) part is a comprehensive summary of the known CaPO4 deposition techniques both currently used and discontinued/underdeveloped ones with brief descriptions of their major physical and chemical principles coupled with the key process parameters (when possible) to inform readers of their existence and remind them of the unused ones. The second (smaller) part includes fleeting essays on the most important properties and current biomedical applications of the CaPO4 deposits with an indication of possible future developments.

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“…There are various long-standing methods of depositing HA onto metallic orthopaedic parts such as chemical vapour deposition, electro spraying, and plasma spraying [28][29][30][31]. These are often inconsistent with the use of alternative materials.…”

Section: Introductionmentioning

confidence: 99%

Characterising Hydroxyapatite Deposited from Solution onto Novel Substrates: Growth Mechanism and Physical Properties

Murphy,

Baez,

Morris

2023

Nanomaterials

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Whilst titanium, stainless steel, and cobalt-chrome alloys are the most common materials for use in orthopaedic implant devices, there are significant advantages in moving to alternative non-metallic substrates. Substrates such as polymers may have advantageous mechanical biological properties whilst other substrates may bring unique capability. A key challenge in the use of non-metal products is producing substrates which can be modified to allow the formation of well-adhered hydroxyapatite films which promote osteointegration and have other beneficial properties. In this work, we aim to develop methodology for the growth of hydroxyapatite films on surfaces other than bulk metallic parts using a wet chemical coating process, and we provide a detailed characterisation of the coatings. In this study, hydroxyapatite is grown from saturated solutions onto thin titanium films and silicon substrates and compared to results from titanium alloy substrates. The coating process efficacy is shown to be dependent on substrate roughness, hydrophilicity, and activation. The mechanism of the hydroxyapatite growth is investigated in terms of initial attachment and morphological development using SEM and XPS analysis. XPS analysis reveals the exact chemical state of the hydroxyapatite compositional elements of Ca, P, and O. The characterisation of grown hydroxyapatite layers by XRD reveals that the hydroxyapatite forms from amorphous phases, displaying preferential crystal growth along the [002] direction, with TEM imagery confirming polycrystalline pockets amid an amorphous matrix. SEM-EDX and FTIR confirmed the presence of hydroxyapatite phases through elemental atomic weight percentages and bond assignment. All data are collated and reviewed for the different substrates. The results demonstrate that once hydroxyapatite seeds, it crystallises in the same manner as bulk titanium whether that be on a titanium or silicon substrate. These data suggest that a range of substrates may be coated using this facile hydroxyapatite deposition technique, just broadening the choice of substrate for a particular function.

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Biocompatible hydroxyapatite ceramic coating on titanium alloys by electrochemical methods via Growing Integration Layers [GIL] strategy: A review

Cited by 14 publications

References 64 publications

Titanium Implants Coated with Hydroxyapatite Used in Orbital Wall Reconstruction—A Literature Review

Titanium Implants Coated with Hydroxyapatite Used in Orbital Wall Reconstruction—A Literature Review

There Are over 60 Ways to Produce Biocompatible Calcium Orthophosphate (CaPO4) Deposits on Various Substrates

Characterising Hydroxyapatite Deposited from Solution onto Novel Substrates: Growth Mechanism and Physical Properties

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