Biocompatible hyperbranched polyglycerol modified β-cyclodextrin derivatives for docetaxel delivery

Solubility and biological activity enhancement of docetaxel via formation of inclusion complexes with three alkylenediamine-modified β-cyclodextrins

“…In vitro antitumor experiments showed that β-CDs-HPG/DTX effectively inhibited proliferation of human breast adenocarcinoma cells. 26 Tao et al reported that the DTX/folate acid-CDs (FA-CDs) inclusion complexes induced apoptosis in KB cells via the intrinsic mitochondrial pathway and displayed antitumor activity in vivo . 27 Ren et al reported that the inclusion complex of DTX with sulfobutyl ether β-CDs (DTX–SBE-β-CDs) was successfully prepared by using the saturated aqueous solution method.…”

Synthesis of glycerol‐thiophene nanoparticles, a suitable sensing platform for voltammetric determination of guaifenesin

“…HPGs are usually synthesized by cationic and anionic ring‐opening polymerization of glycidol. However in the most cases toxic initiators and organic solvents are used which is a challenging issue for biomedical applications 8‐11 . Boronic acids as “green” compounds, are able to initiate cationic ring‐opening polymerization of glycidol 12 .…”

Synthesis of hyperbranched polyglycerols using ascorbic acid as an activator

“…Unique physicochemical and biological properties such as water solubility, multifunctionality which provides many potential sites for the conjugation of therapeutic agents and multivalent interactions, excellent biocompatibility, moderate thermal stability, oxidation resistance, no signicant effects on the conjugates and low toxicity cause high interest for their usage in biological applications. [1][2][3][4] Furthermore, because of their polyether structure and their similarity to PEG, hPGs are expected to show intrinsic ability to avoid mononuclear phagocytic system uptake. 2,5 Also, the in vivo circulation half-lives of hPGs could be controlled by manipulation of their molecular weights.…”

“…[8][9][10][11] Since the rst report on the synthesis of polyglycerol by Sandler et al in 1966, 12 different methods for the preparation of linear and hyperbranched analogues of this polymer, based on anionic and cationic ring opening polymerization of glycidol, have been established. 3,[13][14][15][16][17][18][19] However, a big challenge for the preparation of polyglycerols by conventional anionic and cationic ring opening polymerization is to use toxic initiators, catalysts and organic solvents. [20][21][22] Traces of toxic agents in the nal products induce adverse effects on the biological systems and hamper the biomedical applications of polyglycerols.…”