2010
DOI: 10.1016/j.jcis.2010.04.053
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Biocompatible lecithin-based microemulsions with rhamnolipid and sophorolipid biosurfactants: Formulation and potential applications

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Cited by 107 publications
(76 citation statements)
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“…MEL-A for example has much higher emulsifying activity with soybean oil and tetradecane than polysorbate 80 and is able to form stable waterin-oil microemulsions without addition of co-surfactant or salt . Rhamnolipids and sophorolipids have also been mixed with lecithins to prepare biocompatible microemulsions in which the phase behavior was unaffected by changes in www.intechopen.com temperature and electrolyte concentration, making them desirable for cosmetic and drug delivery applications (Nguyen et al, 2010). In 1988, rhamnolipid liposomes were patented as drug delivery systems, useful as microcapsules for drugs, proteins, nucleic acids, dyes and other compounds, as biomimetic models for biological membranes and as sensors for detecting pH variations.…”
Section: Biosurfactants Potential In Drug Deliverymentioning
confidence: 99%
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“…MEL-A for example has much higher emulsifying activity with soybean oil and tetradecane than polysorbate 80 and is able to form stable waterin-oil microemulsions without addition of co-surfactant or salt . Rhamnolipids and sophorolipids have also been mixed with lecithins to prepare biocompatible microemulsions in which the phase behavior was unaffected by changes in www.intechopen.com temperature and electrolyte concentration, making them desirable for cosmetic and drug delivery applications (Nguyen et al, 2010). In 1988, rhamnolipid liposomes were patented as drug delivery systems, useful as microcapsules for drugs, proteins, nucleic acids, dyes and other compounds, as biomimetic models for biological membranes and as sensors for detecting pH variations.…”
Section: Biosurfactants Potential In Drug Deliverymentioning
confidence: 99%
“…Xie et al, 2005 demonstrated that rhamnolipids could be successfully used to form microemulsions using medium chain alcohols as cosurfactant. Subsequently, the same Authors observed that the phase behavior and microstructure of these microemulsions were rational to the conformational changes of rhamnolipid molecules at the interface of oil/water (Xie et al, 2007 Lecithin-based microemulsions have proven to be desirable in biocompatible formulations due to their tendency to mimic the phospholipid nature of cell membranes (Nguyen et al, 2010). In a recent report Nguyen et al, (2010) formulated and evaluated microemulsions of lecithin/rhamnolipid/sophorolipid biosurfactants with a range of oils.…”
Section: Microemulsionsmentioning
confidence: 99%
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“…Lecithin-based MEs have been desirable as encapsulation carriers due to their tendency to mimic the phospholipid nature of cell membranes [28], and this delivery system could increase the bioavailability of incorporated carotenoids. The highest level (59.67% ± 1.01 encapsulation efficiency -EE) of carotenoids incorporated in MEs was observed by M. oleifera (significant at p < 0.05), followed by Red Pepper/M.…”
Section: Encapsulation Efficiency Of Carotenoids In Mesmentioning
confidence: 99%
“…1). Sophorolipids preserve their function and activity in high salt concentrations and across aw ide temperature range [39,40]. However,t hey show considerable instability at pH values higher than 7.0 -7.5 when they are prone to hydrolysis.…”
Section: Sophorolipidsmentioning
confidence: 99%