Biocompatible Luminescent Nanosized Curcumin: Verified Parameters Affecting Stability and Bioavailability

Mohamed, MostafaM

doi:10.19070/2377-8075-20000238

Cited by 6 publications

(12 citation statements)

References 29 publications

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“…In the current study we aimed to evaluate the in vivo antifungal effect of topical nanocurcumin in treatment of oral candidiasis of mice. Nanocurcumin was prepared by solvent-antisolvent precipitation method which is considered a suitable technique for synthesis of poorly soluble curcumin nanoparticles (22). In our study, the average particles size of nanocurcumin was 122.0 ± 2.704 nm.…”

Section: Discussionmentioning

confidence: 71%

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Evaluation of Topical Application of Nanocurcumin Suspension in Treatment of Oral Candidal Infection (Experimental Study)

Abdelmonem

Moussa

Aboulela

et al. 2022

Alexandria Dental Journal

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INTRODUCTION:Oral candidiasis is the most common human fungal infection resulting from infection of the oral cavity by yeastlike fungus, candida. Its treatment by available topical or systemic antifungal drugs has several problems including toxicity and the development of drug resistance. Hence recent studies have given much attention to molecules from natural sources. Therefore, curcumin is considered one of the promising natural antifungal drugs. It has antifungal properties, but its poor solubility in aqueous solvents results in poor oral bioavailability. To improve the properties of curcumin, recent trails used nanotechnology. The size of nanoparticles can help them to gain entry into cells increasing its solubility and improving its bioavailability. OBJECTIVES: To evaluate the use of topical application of nanocurcumin in treatment of oral candidiasis and compare it to curcumin and nystatin in a murine model. MATERIALS AND METHODS: Thirty-nine female mice were randomly divided into three groups of 13 animals each after induction of oral candidiasis. Group 1 received nanocurcumin at 64 µg/ml. Group 2 received curcumin at 128 µg/ml. Group 3 received nystatin 100000 U/ml. All animals were received treatment topically twice daily for 10 days. The clinical evaluation and microbiological analysis were at baseline, day 5 and day 10. RESULTS: There was no statistical differences between the three studied groups in the number of cured animals at the end of the treatment period (p=0.358). CONCLUSION: Nanocurcumin has a good antifungal effect but further research is needed to get the maximum benefits of these nanoparticles.

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Section: Discussionmentioning

confidence: 71%

“…The mean particles' size as well as surface charge was measured by dynamic light scattering analysis and Zeta potential, respectively. Transmission electron microscope examination of the nanoparticles was conducted to assess the shape and distribution of the particles (22,23).…”

Section: Methods Synthesis and Characterization Of Curcumin Nanoparti...mentioning

confidence: 99%

Evaluation of Topical Application of Nanocurcumin Suspension in Treatment of Oral Candidal Infection (Experimental Study)

Abdelmonem

Moussa

Aboulela

et al. 2022

Alexandria Dental Journal

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“…Moreover, nanofiber scaffold holding the CSCs is used in tissue engineering to assist CSCs’ differentiation. The confocal images of NPs-cellular imaging are reproduced with permission[ 196 ]. Created with BioRender.com.…”

Section: Nanotechnology and Cscsmentioning

confidence: 99%

Cardiac stem cells: Current knowledge and future prospects

Mehanna¹,

Essawy²,

Barkat³

et al. 2022

WJSC

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Regenerative medicine is the field concerned with the repair and restoration of the integrity of damaged human tissues as well as whole organs. Since the inception of the field several decades ago, regenerative medicine therapies, namely stem cells, have received significant attention in preclinical studies and clinical trials. Apart from their known potential for differentiation into the various body cells, stem cells enhance the organ's intrinsic regenerative capacity by altering its environment, whether by exogenous injection or introducing their products that modulate endogenous stem cell function and fate for the sake of regeneration. Recently, research in cardiology has highlighted the evidence for the existence of cardiac stem and progenitor cells (CSCs/CPCs). The global burden of cardiovascular diseases’ morbidity and mortality has demanded an in-depth understanding of the biology of CSCs/CPCs aiming at improving the outcome for an innovative therapeutic strategy. This review will discuss the nature of each of the CSCs/CPCs, their environment, their interplay with other cells, and their metabolism. In addition, important issues are tackled concerning the potency of CSCs/CPCs in relation to their secretome for mediating the ability to influence other cells. Moreover, the review will throw the light on the clinical trials and the preclinical studies using CSCs/CPCs and combined therapy for cardiac regeneration. Finally, the novel role of nanotechnology in cardiac regeneration will be explored.

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“…The curcumin powder (Alpha Chemika, Mumbai, India) was dissolved in acetone (10 mg/mL). One mL of the prepared solution was added to 15 mL deionized water (ultra-purified from Millipore Milli-Q system "resistivity ∼ 80 MΩ cm") containing 0.5% w/v polyvinyl pyrrolidone (PVP; Sigma-Aldrich, St. Luis, MO, USA) in a drop-wise manner under stirring at 500 rpm for 1 min [25].…”

Section: Synthesis and Characterization Of Curcumin Nanoparticlesmentioning

confidence: 99%

“…The mean particles' size and the surface charge were measured by dynamic light scattering analysis using Zeta-seizer (Nano ZS, Malvern Instruments, Worcestershire, UK). Transmission electron microscope (TEM; JOEL, JSM-6360LA, JAPAN) examination of the nanoparticles was conducted to assess the shape, size, and distribution of the particles [25,26].…”

Section: Synthesis and Characterization Of Curcumin Nanoparticlesmentioning

confidence: 99%

Curcumin nanoparticles: the topical antimycotic suspension treating oral candidiasis

et al. 2022

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Phytotherapeutics is widely used nowadays as an alternative to the current antifungal drugs to reduce their side effects. Curcumin, with its wide therapeutic array as antioxidant and anti-inflammatory agent, is one of the natural compounds that ha..s an antifungal effect, especially when being used at nanoscale to increase its bioavailability. Our research aimed to evaluate clinically and microbiologically the effect of using topical nanocurcumin suspension to treat oral candidiasis. After 4 days from induction of oral candidiasis (baseline), we randomly divided 39 female BALB/c mice into three groups of 13 animals; nanocurcumin, nystatin, and sham groups. All animals in nanocurcumin and nystatin groups received topical treatment twice daily for 10 days. Then, we performed clinical and microbiological evaluations at baseline, day 5, and day 10. By the end of treatment, our results revealed that nanocurcumin promoted a significant reduction in the number of candida colonies. There was no statistically significant difference neither clinically nor microbiologically between nanocurcumin and nystatin groups. In conclusion, nanocurcumin has a good antifungal effect as nystatin, however, its therapeutic efficacy takes a longer time to appear than nystatin. The enhanced bioavailability of curcumin at the nanoscale qualifies this nano-herb as a promising alternative therapy for oral candidiasis, evading nystatin-associated morbidity.

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Biocompatible Luminescent Nanosized Curcumin: Verified Parameters Affecting Stability and Bioavailability

Cited by 6 publications

References 29 publications

Evaluation of Topical Application of Nanocurcumin Suspension in Treatment of Oral Candidal Infection (Experimental Study)

Evaluation of Topical Application of Nanocurcumin Suspension in Treatment of Oral Candidal Infection (Experimental Study)

Cardiac stem cells: Current knowledge and future prospects

Curcumin nanoparticles: the topical antimycotic suspension treating oral candidiasis

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