Biocompatible Magnetite/Gold Nanohybrid Contrast Agents via Green Chemistry for MRI and CT Bioimaging

Narayanan, Sreeja; Sathy, Binulal N.; Mony, Ullas; Koyakutty, Manzoor; Nair, Shantikumar V.; Menon, Deepthy

doi:10.1021/am201311c

Cited by 234 publications

(153 citation statements)

References 47 publications

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“…Narayanan et al [31] synthesized superparamagnetic magnetite/gold (Fe 3 O 4 /Au) hybrid nanoparticles at room temperature using grape seed proanthocyanidin (GSP) for the first time. These nanohybrids were used as better CT contrast agents than conventionally used iodine-contrast agents.…”

Section: Other Plant Species Senthil and Rameshmentioning

confidence: 99%

Plant-Mediated Green Synthesis of Iron Nanoparticles

Herlekar

Siddhivinayak

Kumar

2014

Journal of Nanoparticles

282

104

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In the recent years, nanotechnology has emerged as a state-of-the-art and cutting edge technology with multifarious applications in a wide array of fields. It is a very broad area comprising of nanomaterials, nanotools, and nanodevices. Amongst nanomaterials, majority of the research has mainly focused on nanoparticles as they can be easily prepared and manipulated. Physical and chemical methods are conventionally used for the synthesis of nanoparticles; however, due to several limitations of these methods, research focus has recently shifted towards the development of clean and eco-friendly synthesis protocols. Magnetic nanoparticles constitute an important class of inorganic nanoparticles, which find applications in different areas by virtue of their several unique properties. Nevertheless, in comparison with biological synthesis protocols for noble metal nanoparticles, limited study has been carried out with respect to biological synthesis of magnetic nanoparticles. This review focuses on various studies outlining the novel routes for biosynthesis of these nanoparticles by plant resources along with outlining the future scope of work in this area.

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Section: Other Plant Species Senthil and Rameshmentioning

confidence: 99%

Plant-Mediated Green Synthesis of Iron Nanoparticles

Herlekar

Siddhivinayak

Kumar

2014

Journal of Nanoparticles

282

104

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“…The efficiency of iron oxide probes as T 2 contrast agent is size-dependent and increases with higher particle crystallinity [26,79,86,96,97]. However, these NPs generally synthesized at low temperatures, have poor crystallinity associated with small size, and lack of monodispersity, as also found for other nanomaterials [98].…”

Section: Figure 1 Herementioning

confidence: 94%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville³

2016

Nano Online

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The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in synthesis protocol and characterization of these materials whereas toxicological issues are sometimes incomplete. Nanoparticle-based contrast agents tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of 2 imaging modalities. Multimodal nanoparticles (NPs) are much more efficient than conventional molecular-scale contrast agents. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides specific applications for classical imaging, (MRI, PET, CT, US, PAI) are also mentioned less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA).Perspectives on multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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“…The efficiency of iron oxide probes as T 2 CA is sizedependent and increases with higher particle crystallinity [26,79,86,96,97] . However, these NPs, generally synthesized at low temperatures, have poor crystallinity associated with small size and lack of monodispersity, as also found for the other nanomaterials [98] .…”

Section: T 2 Np-based Casmentioning

confidence: 99%

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Trequesser¹,

Seznec²,

Delville

2013

Nanotechnology Reviews

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Abstract:The successful development of nanomaterials illustrates the considerable interest in the development of new molecular probes for medical diagnosis and imaging. Substantial progress was made in the synthesis protocol and characterization of these materials, whereas toxicological issues are sometimes incomplete. Nanoparticlebased contrast agents (CAs) tend to become efficient tools for enhancing medical diagnostics and surgery for a wide range of imaging modalities. The multimodal nanoparticles (NPs) are much more efficient than the conventional molecular-scale CAs. They provide new abilities for in vivo detection and enhanced targeting efficiencies through longer circulation times, designed clearance pathways, and multiple binding capacities. Properly protected, they can safely be used for the fabrication of various functional systems with targeting properties, reduced toxicity, and proper removal from the body. This review mainly describes the advances in the development of mono-to multimodal NPs and their in vitro and in vivo relevant biomedical applications ranging from imaging and tracking to cancer treatment. Besides the specific applications for classical imaging (magnetic resonance imaging, positron emission tomography, computed tomography, ultrasound, and photoacoustic imaging), the less common imaging techniques such as terahertz molecular imaging (THMI) or ion beam analysis (IBA) are mentioned. The perspectives on the multimodal theranostic NPs and their potential for clinical advances are also mentioned.

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Biocompatible Magnetite/Gold Nanohybrid Contrast Agents via Green Chemistry for MRI and CT Bioimaging

Cited by 234 publications

References 47 publications

Plant-Mediated Green Synthesis of Iron Nanoparticles

Plant-Mediated Green Synthesis of Iron Nanoparticles

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

Functionalized nanomaterials: their use as contrast agents in bioimaging: mono- and multimodal approaches

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