2016
DOI: 10.1002/jps.24706
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Biocompatible Nanoemulsions for Improved Aceclofenac Skin Delivery: Formulation Approach Using Combined Mixture-Process Experimental Design

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Cited by 28 publications
(13 citation statements)
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“…Sucrose Palmitate (2%) and Sucrose Stearate (0.5%) in a tape-stripping (12×) experiment in human subjects increased skin absorption of the drug aceclofenac, which was then detected at all depths of the stratum corneum. 46 Sucrose Oleate and Sucrose Laurate, both tested at 2% and 10% in human subjects, increased skin penetration of the drug 4-hydroxy-benzonitrile. 47…”
Section: Toxicokinetic Studiesmentioning
confidence: 96%
See 1 more Smart Citation
“…Sucrose Palmitate (2%) and Sucrose Stearate (0.5%) in a tape-stripping (12×) experiment in human subjects increased skin absorption of the drug aceclofenac, which was then detected at all depths of the stratum corneum. 46 Sucrose Oleate and Sucrose Laurate, both tested at 2% and 10% in human subjects, increased skin penetration of the drug 4-hydroxy-benzonitrile. 47…”
Section: Toxicokinetic Studiesmentioning
confidence: 96%
“…However, no adverse skin reactions were visible and the treatment was tolerable to the skin. 46 Human patch tests evaluating Sucrose Pentahydroxystearate (100%) and Sucrose Tetraisostearate (100%) for irritation were negative (0% after 24 hours, no further details specified). 58 Sucrose Polycottonseedate (up to 1% in formulation) was slightly irritating in a 21-day occlusive patch test in human subjects.…”
Section: Dermal Irritation and Sensitization Studiesmentioning
confidence: 99%
“…A number of NSAIDs have been available as gel and cream formulations for many years. There is extensive literature focused on the development and evaluation of ME and NE systems for topical delivery of a number of NSAIDs including diclofenac [ 62 , 63 ], aceclofenac [ 57 , 64 , 65 ], piroxicam [ 66 ], indomethacin [ 67 , 68 , 69 ], ibuprofen, celecoxib [ 70 , 71 ], etoricoxib [ 72 ], naproxen [ 73 ], flufenamic acid [ 50 , 74 , 75 ], ketoprofen [ 39 , 76 , 77 ], flurbiprofen [ 78 ], lornoxicam [ 79 ], and meloxicam [ 80 ]. Consequently, we have focused our discussion on this drug class to illustrate the development and potential of ME/NE formulations for topical and transdermal delivery.…”
Section: Skin Delivery From Nano and Microemulsionsmentioning
confidence: 99%
“…Used to improve solubility of poorly soluble drugs [142]; medicated chewing gums [120]; bioactive dressings [128]; or tablets [121,139], oleogels [144,145], organogels for cardiovascular diseases [118], nanoparticles with amoxicillin trihydrate and thymol [131,134], novel excipients [129,136,146] and oils mixture with salicylic acid for ointment [143] formulation; itraconazole for oral [27,127], gel with loratadine [148], tablets of metformin [130], controlled release of ketoprofen [23] and excipients with finasteride [126] formulation; emulsion formulation of vitamins [119], of aceclofenac [122], of raloxifen [135], of aprepitant [123], of catechin [28], of darunavir [117], of lopinavir [116], of butenafine hydrochloride [132], of cathepsin K inhibitor [140], of telmisartan [138], of olmesartan medoxomil [137], of bovine serum albumin [141], of nelfinavir mesylate [124], of docetaxel [125], of nutraceutical products [147] and oxidative stability avocado oil [133].…”
Section: Application Of Mixture Design In Pharmaceutical Healthmentioning
confidence: 99%