Biocompatible nanofiber scaffolds on metal for controlled release and cell colonization

Dong, Wenjun; Zhang, Tierui; McDonald, Michelle M.; Padilla, Carmen S.; Epstein, Joshua; Tian, Zhengrong Ryan

doi:10.1016/j.nano.2006.10.005

Cited by 25 publications

(26 citation statements)

References 28 publications

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“…30 The nanotopography of nanonetwork structures with TNS nanofeatures is affected by temperature, treatment time, and alkaline concentration. 20,[31][32][33] The objectives of the present study were twofold: first, we aimed to investigate the changes in TNS, such as roughness, wettability, and surface structure induced by various alkaline concentrations (2.5, 5.0, 7.5, 10.0, and 12.5 M), and second, we aimed to evaluate the influence of such modified nanonetwork structures with TNS nanofeatures, with different alkaline concentrations, on the osteogenic differentiation of rat BMMSCs. To the best of our knowledge, this is the first study to evaluate the effects of titanium surfaces with nanonetwork structures formed by various alkali concentrations at room temperature on osteogenic differentiation.…”

Section: Introductionmentioning

confidence: 99%

Osteogenic activity of titanium surfaces with nanonetwork structures

Huan¹,

Komasa²,

Taguchi³

et al. 2014

IJN

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Background Titanium surfaces play an important role in affecting osseointegration of dental implants. Previous studies have shown that the titania nanotube promotes osseointegration by enhancing osteogenic differentiation. Only relatively recently have the effects of titanium surfaces with other nanostructures on osteogenic differentiation been investigated. Methods In this study, we used NaOH solutions with concentrations of 2.5, 5.0, 7.5, 10.0, and 12.5 M to develop a simple and useful titanium surface modification that introduces the nanonetwork structures with titania nanosheet (TNS) nanofeatures to the surface of titanium disks. The effects of such a modified nanonetwork structure, with different alkaline concentrations on the osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMMSCs), were evaluated. Results The nanonetwork structures with TNS nanofeatures induced by alkali etching markedly enhanced BMMSC functions of cell adhesion and osteogenesis-related gene expression, and other cell behaviors such as proliferation, alkaline phosphatase activity, extracellular matrix deposition, and mineralization were also significantly increased. These effects were most pronounced when the concentration of NaOH was 10.0 M. Conclusion The results suggest that nanonetwork structures with TNS nanofeatures improved BMMSC proliferation and induced BMMSC osteogenic differentiation. In addition, the surfaces formed with 10.0 M NaOH suggest the potential to improve the clinical performance of dental implants.

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Section: Introductionmentioning

confidence: 99%

Osteogenic activity of titanium surfaces with nanonetwork structures

Huan¹,

Komasa²,

Taguchi³

et al. 2014

IJN

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“…Subsequently, the membrane (1.0 cm × 1.0 cm) was soaked in a 1.0 ml solution of 10 g/L AP173 or AP713 at room temperature for 12 hours, them washed with deionized (DI) water before the use. 82 These nanowired-compounds were administered separately over the traumatized spinal cord 5 min after injury in identical manner. These animals were also allowed to survive 5 h after injury.…”

Section: Titanium Nanowires and Drug Delivery In Scimentioning

confidence: 99%

Nano-Drug Delivery and Neuroprotection in Spinal Cord Injury

Sharma¹,

Ali²,

Tian³

et al. 2009

j nanosci nanotechnol

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Recently nano-drug delivery to the central nervous system (CNS) has been shown to be more effective than the parent compound by itself. An increased availability of the drug for longer periods to the brain or spinal cord and/or a decrease in the drug metabolism altogether could lead to potentiation of the pharmacological activity of the nano-delivered compounds. However, it is still unclear whether the nanocarriers used to deliver the drugs may itself has any potential neurotoxic activity. Although, nanodrug-delivery appears to be a quite promising therapeutic tool for the future clinical therapy, its advantages and limitations for the routine use of patients still needs to be elucidated. Our laboratory is engaged to study a plethora of potential neuroprotective novel compounds delivered to the CNS using nanowiring techniques following brain or spinal cord trauma. Our investigations show that nanowired drugs, if delivered locally following spinal cord injury achieve better neuroprotection than the parent compounds. This effect of nano-drug delivery appears to be very selective in nature. Thus, a clear differentiation based on the compounds used for nano-drug delivery can be seen on various pathological parameters in spinal cord injury. These observations suggest that nanowiring may itself do not induce neuroprotection, but enhance the neuroprotective ability of compounds after trauma. This review describes some recent advances in nano-drug delivery to the CNS in relation to novel neuroprotective strategies with special emphasis on spinal cord trauma based on our own observations and recent findings from our laboratory investigations.

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“…The titanate nanowire was prepared based on previously described method [7][8][9]. Before the synthesis, titanium plates 20 mm Â 10 mm were inserted in 10 mL of acetone at room temperature, ultrasonicated for 15 min, then ultrasonicated for 10 min in 10 mL of absolute ethylalcohol, and rinsed with deionized water thereafter.…”

Section: Preparation Of Individual Tio 2 Nanowirementioning

confidence: 99%

“…Young's modulus is normally obtained from a measurement of the beam deflection as a function of the applied force. For a clamped-clamped beam used here, the resulting curve is described by the following well-known equation [7]: The individual TiO 2 nanowires were prepared on the Ti foil directly after a hydrothermal reaction for 8 h at 240°C in a 1.2 mol/L NaOH solution [8,9]. SEM photomicrographs demonstrates that dense long nanowires (about 250-950 nm in width and 2-30 μm in length) have grown on the Ti foil.…”

Section: Model Of Micro-cantilever Test For Individual Tio 2 Nanowirementioning

confidence: 99%

“…Various methods for preparation of the TiO 2 nanorods, nanofibers, nanowires and nanotubes, including sol-gel, electrospinning, electrochemical and hydrothermal synthesis methods have been reported [1]. Recently, our research group introduced Ag particles on titanate nanowires and the heteronanostructured Ag/titanate nanowires were assembled into porous, flexible membranes with enhanced photocatalytic properties and bactericidal activities [7] and TiO 2 Nanowire were also prepared as multifunctional manowire bioscaffolds and microelectrode for controlled on-site drug release, photocatalytic sterilization and sensors [8][9][10]. It is important to accurately measure the mechanical properties, which is key to gaining fundamental understanding of surface effects on such properties.…”

Section: Introductionmentioning

confidence: 99%

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