Biocompatible nanoparticles containing hydrophobic nickel-bis(dithiolene) complexes for NIR-mediated doxorubicin release and photothermal therapy

Abstract

Nickel-bis(dithiolene) containing NPs: controlled release of Dox and photothermal therapy under NIR Irradiation.

A Multifunctional Dye‐doped Liquid Crystal Polymer Actuator: Light‐Guided Transportation, Turning in Locomotion, and Autonomous Motion

“…A liquid crystal elastomer (LCE) bearing cinnamyl comonomer units for photocrosslinking of polymer chains and N,N′‐dialkylimidazolidine‐2,4,5‐trithone nickel complex carrying 2‐butyloctyl carbon chains as a molecular photothermal agent, denoted as imNi8(4) hereafter . The metal–bis(dithiolene) complex was selected for its dominant absorption in the NIR spectral region (making the light‐controlled actuator eventually appealing for biomedical uses), its high photothermal stability and high photothermal conversion efficiency, and its good dispersity in polymers . Figure b shows the UV/Vis‐NIR absorption spectrum of the NIR dye in solution and the spectra of a LCE/imNi8(4) film (0.2 wt %) recorded before and after photocrosslinking through dimerization of cinnamyl groups (Supporting Information, Figure S1) for different times.…”

“…[26] Them etal-bis(dithiolene) complex was selected for its dominant absorption in the NIR spectral region (making the light-controlled actuator eventually appealing for biomedical uses), its high photothermal stability and high photothermal conversion efficiency,a nd its good dispersity in polymers. [27] Figure 1b shows the UV/Vis-NIR absorption spectrum of the NIR dye in solution and the spectra of aLCE/ imNi8(4) film (0.2 wt %) recorded before and after photocrosslinking through dimerization of cinnamyl groups (Supporting Information, Figure S1) for different times.E ven at such as mall content in the polymer,t he absorption peak of imNi8(4) centered at 974 nm is prominent and unchanged after 90 min UV exposure,i mplying the stability of the dye. Figure 1c shows the temperature profiles measured with an infrared camera when astrip of LCE/imNi8(4) (0.2 wt %) was exposed to 980 nm laser of varying intensity.T he achievable temperature depends on the laser power (similar result obtained with at hermocouple;S upporting Information, Figure S2).…”

(Photo)Thermal Stimulation of Functional Dithiolene Complexes in Soft Matter

“…The photoacoustic signal coming from the nickel‐bis(dithiolene) complex is easily detected and its intensity is directly proportional to the concentration of complex and to the laser energy (Figure ). These last results show that this class of complexes can also be used as exogenous contrast agents for photoacoustic bioimaging …”

“…Photoacoustic signal detected depending on the power of laser pulses and on the liposome concentration in DMEM + 10 % FBS medium (standard deviations calculated on 20 images). Reproduced from ref . Copyright (2019), with permission from the American Chemical Society.…”

“…Along these lines, a hydrophobic nickel‐bis(dithiolene) complex [M(dphedt) 2 ] 0 bearing four OC 12 H 25 fragments was encapsulated within PEG‐b‐PMLABe type block copolymer nanoparticles using the nanoprecipitation technique . The poly(malic acid), PMLA, and its derivatives is an attractive polymer to develop (bio)degradable and biocompatible block copolymers‐based nanocarriers .…”