Biocompatible novel starch/polyaniline composites: Characterization, anti-cytotoxicity and antioxidant activity

Saikia, Jyoti Prasad; Banerjee, Somik; Konwar, Bolin Kumar; Kumar, Ashok

doi:10.1016/j.colsurfb.2010.07.005

Cited by 91 publications

(64 citation statements)

References 24 publications

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“…The free radical scavenging capacity of the samples increased with a greater fraction of NR-PANI in the blends. Saikia et al have made similar observations with starch/PANI composites where higher free radical scavenging, also measured using the DPPH assay, was achieved with increased PANI fraction in the composites [45]. Similar, observations have been made with regards to polyethylene terephthalate/NR-PANI blends [44].…”

Section: Free Radical Scavenging Activitysupporting

confidence: 53%

Characterization of antioxidant low density polyethylene/polyaniline blends prepared via extrusion

Nand

Ray

Travaš-Sejdić

et al. 2012

Materials Chemistry and Physics

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Section: Free Radical Scavenging Activitysupporting

confidence: 53%

Characterization of antioxidant low density polyethylene/polyaniline blends prepared via extrusion

Nand

Ray

Travaš-Sejdić

et al. 2012

Materials Chemistry and Physics

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“…The other reason is that polyaniline is a radical scavenger, which may interfere with the crosslinking reaction to some extent. 3,13,14 These results suggest that eGels with different nEOA content may meet different demands for clinical applications as an injectable hydrogel.…”

Section: Synthesis Of Egelmentioning

confidence: 86%

“…1,6,7,[10][11][12] Furthermore, the electroactive materials can resist the oxidative damage to tissue during tissue regeneration by scavenging free radicals. 13,14 In general, such hydrogels can be prepared by introducing conducting composites into injectable degradable hydrogels through chemical/physical conjugation or simple mechanical mixing. [1][2][3]5,6,[10][11][12][13][14][15][16] Among the used conducting composites, carbon nanotubes and oligomers of conducting polymers are the most popular due to their superb properties.…”

Section: Introductionmentioning

confidence: 99%

“…13,14 In general, such hydrogels can be prepared by introducing conducting composites into injectable degradable hydrogels through chemical/physical conjugation or simple mechanical mixing. [1][2][3]5,6,[10][11][12][13][14][15][16] Among the used conducting composites, carbon nanotubes and oligomers of conducting polymers are the most popular due to their superb properties. Carbon nanotubes can impart both high mechanical and electrical conductivity properties to hydrogels, but the difficulty in batch production with uniform and repeated structure and properties, the weak interactions with hydrophilic hydrogels and the tendency to aggregate due to their hydrophobicity, and the unsatisfactory biocompatibility/toxicity limit their biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

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Injectable, degradable, electroactive nanocomposite hydrogels containing conductive polymer nanoparticles for biomedical applications

Wang¹,

Wang²,

Teng³

2016

IJN

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Injectable electroactive hydrogels (eGels) are promising in regenerative medicine and drug delivery, however, it is still a challenge to obtain such hydrogels simultaneously possessing other properties including uniform structure, degradability, robustness, and biocompatibility. An emerging strategy to endow hydrogels with desirable properties is to incorporate functional nanoparticles in their network. Herein, we report the synthesis and characterization of an injectable hydrogel based on oxidized alginate (OA) crosslinking gelatin reinforced by electroactive tetraaniline-graft-OA nanoparticles (nEOAs), where nEOAs are expected to impart electroactivity besides reinforcement without significantly degrading the other properties of hydrogels. Assays of transmission electron microscopy, 1 H nuclear magnetic resonance, and dynamic light scattering reveal that EOA can spontaneously and quickly self-assemble into robust nanoparticles in water, and this nanoparticle structure can be kept at pH 3~9. Measurement of the gel time by rheometer and the stir bar method confirms the formation of the eGels, and their gel time is dependent on the weight content of nEOAs. As expected, adding nEOAs to hydrogels does not cause the phase separation (scanning electron microscopy observation), but it improves mechanical strength up to ~8 kPa and conductivity up to ~10 −6 S/cm in our studied range. Incubating eGels in phosphate-buffered saline leads to their further swelling with an increase of water content <6% and gradual degradation. When growing mesenchymal stem cells on eGels with nEOA content ≤14%, the growth curves and morphology of cells were found to be similar to that on tissue culture plastic; when implanting these eGels on a chick chorioallantoic membrane for 1 week, mild inflammation response appeared without any other structural changes, indicating their good in vitro and in vivo biocompatibility. With injectability, uniformity, degradability, electroactivity, relative robustness, and biocompatibility, these eGels may have a huge potential as scaffolds for tissue regeneration and matrix for stimuli responsive drug release.

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“…It was reported that such dressing exhibited antibacterial and hemostatic properties with proper adhesiveness for cutaneous wound healing (17). Polyaniline endowed anti -oxidant and electroactivity to the dressing causing appropriate wound repair (18). A conductive hydrogel can provide the 3D microenvironment for enhanced tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Bio - Conductive Scaffold Based on Agarose - Polyaniline for Tissue Engineering

et al. 2017

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Architecting novel scaffold for tissue engineering has attracted significant attention. Biomimic scaffolds can enhance cellular activity and tissue regeneration. Conductive scaffold exhibited ameliorated regeneration and tissue repair. In this research, conductive hydrogel based on agarose/polyaniline was synthesized to evaluate hydrogel performance as a novel candidate for tissue engineering. Agarose/polyaniline was synthesized using in -situ oxidative polymerization to achieve conductive hydrogel. Fourier Transform Infrared Spectroscopy (FTIR) was utilized for characterization of the hydrogel. Cyclic voltammetry and conductivity measurement were applied for determining the electro -activity and hydrogel conductivity. Hydrogel conductivity was around 10 to 4 S/cm and exhibited two redox peaks attributed to electroactive transitional state around 0.8 and 0.6. Polyaniline addition to hydrogel decreased the hydrogel swelling capacity because of the hydrophobic nature of polyaniline from 60% to 30%. Cell viability test revealed that the conductive substrate enhanced cellular proliferation. Agarose/polyaniline can be widely utilized in tissue engineering because of adjustable swelling behavior and conductivity, which can affect cellular activity and regeneration.

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Biocompatible novel starch/polyaniline composites: Characterization, anti-cytotoxicity and antioxidant activity

Cited by 91 publications

References 24 publications

Characterization of antioxidant low density polyethylene/polyaniline blends prepared via extrusion

Characterization of antioxidant low density polyethylene/polyaniline blends prepared via extrusion

Injectable, degradable, electroactive nanocomposite hydrogels containing conductive polymer nanoparticles for biomedical applications

Bio - Conductive Scaffold Based on Agarose - Polyaniline for Tissue Engineering

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