Biocompatible Silk Printed Optical Waveguides

Parker, Stephanie; Domachuk, P.; Amsden, Jason J.; Bressner, Jason; Lewis, Jennifer A.; Kaplan, David L.; Omenetto, Fiorenzo G.

doi:10.1002/adma.200801580

Cited by 332 publications

(307 citation statements)

References 24 publications

(39 reference statements)

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“…provides a convenient interface between the biocompatible waveguides and conventional optical systems. Loss in the waveguide core was measured to be 2.0 dB/cm which is significantly higher than losses reported previously in silk [18]. We believe this is due to surface scattering by the rough edges of the film.…”

Section: Resultsmentioning

confidence: 45%

“…1(A)). The core of the waveguide was a long narrow strip of silk film with an index of refraction of 1.54 [18]. The silk film was surrounded by a silk hydrogel comprised of greater than 90% water resulting in a refractive index of around 1.34.…”

Section: Introductionmentioning

confidence: 99%

“…These waveguides had low loss (∼0.5 dB/cm) propagation but were not free-standing limiting their utility for in vivo applications [18].…”

Section: Introductionmentioning

confidence: 99%

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Biocompatible silk step-index optical waveguides

Applegate¹,

Perotto²,

Kaplan³

et al. 2015

Biomed. Opt. Express

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Biocompatible optical waveguides were constructed entirely of silk fibroin. A silk film (n=1.54) was encapsulated within a silk hydrogel (n=1.34) to form a robust and biocompatible waveguide. Such waveguides were made using only biologically and environmentally friendly materials without the use of harsh solvents. Light was coupled into the silk waveguides by direct incorporation of a glass optical fiber. These waveguides are extremely flexible, and strong enough to survive handling and manipulation. Cutback measurements showed propagation losses of approximately 2 dB/cm. The silk waveguides were found to be capable of guiding light through biological tissue. #246610Received 23

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Section: Resultsmentioning

confidence: 45%

Section: Introductionmentioning

confidence: 99%

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Biocompatible silk step-index optical waveguides

Applegate¹,

Perotto²,

Kaplan³

et al. 2015

Biomed. Opt. Express

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“…Furthermore, these values are one up to two orders of magnitude lower in the decibel scale than those published so far for bioresorbable optical fibers, thus showing the advantage in using phosphate glass based optical waveguides for bioresorbable optics [7,9,10,14,15].…”

mentioning

confidence: 56%

“…Enhancing and characterizing the optical properties of opportune compositions of CPGs allowed overcoming some of the limitations of polymers, such as high attenuation and poor transparency in the blue and near UV region [13]. Using CPGs, the feasibility of bioresorbable optical fibers was previously demonstrated, with attenuation loss coefficients of 1.9 and 4.7 dB m À1 , at 1300 and 633 nm, respectively, that are 1 to 2 orders of magnitude lower as compared to what reported so far for bioresorbable waveguides [7,8,10,14,15]. The availability of bioresorbable fibers can open new perspectives in clinical applications.…”

Section: Introductionmentioning

confidence: 99%

Towards the use of bioresorbable fibers in time‐domain diffuse optics

Sieno

Boetti

Mora

et al. 2017

Journal of Biophotonics

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In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 mm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for timedomain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500-1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes. Picture: Microscopy image of the 100 mm core bioresorbable fiber.

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