Biocompatible ultrananocrystalline diamond coatings for implantable medical devices

Auciello, O.; Gurman, Pablo; Guglielmotti, M.B.; Olmedo, Daniel Gustavo; Berra, Alejandro; Saravia, Mario

doi:10.1557/mrs.2014.134

Cited by 33 publications

(28 citation statements)

References 37 publications

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“…Among such coatings, Ultrananocrystalline diamond (UNCD) represents a new paradigm in multifunctional materials. UNCD presents a unique synergistic combination of outstanding mechanical (greater hardness as compared to any other material and high fracture resistance/coefficient), tribological (one of the lowest coefficients of friction (∼0.02 − 0.04) of any coating developed today, and wear), chemical (extreme resistance to corrosive attack by acids or body fluids), electrical (highly conductive with nitrogen atoms in the grain boundaries of films or boron atoms substituting carbon atoms in the diamond lattice of the film), and biocompatibility properties …”

Section: Introductionmentioning

confidence: 99%

“…Diamond films are of great interest and are being explored on account of their many current and potential applications, with the aims to obtain a new generation of multifunctional devices . In this regard, there are a number of research groups investigating the advantages of UNCD and its potential use in biomedical and biotechnological applications.…”

Section: Introductionmentioning

confidence: 99%

“…Adhesion of the coating to the substrate is a critical issue from the perspective of the mechanical performance and biocompatibility of the coated‐implant . Although UNCD shows strong adhesion to substrates, the potential release of particulate material into the biological milieu cannot be ruled out.…”

Section: Introductionmentioning

confidence: 99%

“…UNCD presents a unique synergistic combination of outstanding mechanical (greater hardness as compared to any other material and high fracture resistance/coefficient), tribological (one of the lowest coefficients of friction (0.02 2 0.04) of any coating developed today, and wear), 14,15 chemical (extreme resistance to corrosive attack by acids or body fluids), electrical (highly conductive with nitrogen atoms in the grain boundaries of films or boron atoms substituting carbon atoms in the diamond lattice of the film), 16 and biocompatibility properties. 15,[17][18][19][20] Diamond films are of great interest and are being explored on account of their many current and potential applications, with the aims to obtain a new generation of multifunctional devices. 18 In this regard, there are a number of research groups investigating the advantages of UNCD and its potential use in biomedical and biotechnological applications.…”

Section: Introductionmentioning

confidence: 99%

“…15,[17][18][19][20] Diamond films are of great interest and are being explored on account of their many current and potential applications, with the aims to obtain a new generation of multifunctional devices. 18 In this regard, there are a number of research groups investigating the advantages of UNCD and its potential use in biomedical and biotechnological applications. In comparison with other kinds of diamond, the nanotopography of UNCD facilitates adhesion, proliferation, and metabolism of different cellular types, in line with the nanoscale extracellular matrix of tissue.…”

Section: Introductionmentioning

confidence: 99%

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Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices

et al. 2016

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Although Ultrananocrystalline diamond (UNCD) has been proposed as a coating material for titanium biomedical implants, the biological effects and toxicity of UNCD particles that could eventually detach have not been studied to date. The biokinetics and biological effects of UNCD compared to titanium dioxide (TiO ) nanoparticles was evaluated in vivo using Wistar rats (n = 30) i.p. injected with TiO , UNCD or saline solution. After 6 months, blood, lung, liver, and kidney samples were histologically analyzed. Oxidative damage by membrane lipidperoxidation (thiobarbituric acid reactive substances-TBARS), generation of reactive oxygen species (superoxide anion- O2-), and antioxidant enzymes (superoxide dismutase-SOD, catalase-CAT) was evaluated in lung and liver. Histologic observation showed agglomerates of TiO or UNCD in the parenchyma of the studied organs, though there were fewer UNCD than TiO deposits. In addition, TiO caused areas compatibles with foci of necrosis in the liver and renal hyaline cylinders. Regarding UNCD, no membrane damage (TBARS) or mobilization of enzymatic antioxidants was observed either in lung or liver samples. No variations in O2- generation were observed in lung (Co: 35.1 ± 4.02 vs. UNCD: 48 ± 9.1, p > 0.05). Conversely, TiO exposure caused production of O2- in alveolar macrophages and consumption of catalase (p < 0.05). The studied parameters suggest that UNCD caused neither biochemical nor histological alterations, and therefore may prove useful as a surface coating for biomedical implants. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2408-2415, 2017.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices

et al. 2016

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Ultrathin Diamond Nanofilms—Development, Challenges, and Applications

Handschuh‐Wang

Wang

Tang

2021

Small

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Diamond is a highly attractive material for ample applications in material science, engineering, chemistry, and biology because of its favorable properties. The advent of conductive diamond coatings and the steady demand for miniaturization in a plethora of economic and scientific fields resulted in the impetus for interdisciplinary research to develop intricate deposition techniques for thin (≤1000 nm) and ultra‐thin (≤100 nm) diamond films on non‐diamond substrates. By virtue of the lowered thickness, diamond coatings feature high optical transparency in UV–IR range. Combined with their semi‐conductivity and mechanical robustness, they are promising candidates for solar cells, optical devices, transparent electrodes, and photochemical applications. In this review, the difficulty of (ultra‐thin) diamond film development and production, introduction of important stepping stones for thin diamond synthesis, and summarization of the main nucleation procedures for diamond film synthesis are elucidated. Thereafter, applications of thin diamond coatings are highlighted with a focus on applications relying on ultrathin diamond coatings, and the excellent properties of the diamond exploited in said applications are discussed, thus guiding the reader and enabling the reader to quickly get acquainted with the research field of ultrathin diamond coatings.

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Advanced and in situ transmission electron microscopy of diamond: A review

Jäger

2021

Semiconductors and Semimetals

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Biocompatible ultrananocrystalline diamond coatings for implantable medical devices

Abstract: Abstract

Cited by 33 publications

References 37 publications

Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices

Biokinetics and tissue response to ultrananocrystalline diamond nanoparticles employed as coating for biomedical devices

Ultrathin Diamond Nanofilms—Development, Challenges, and Applications

Advanced and in situ transmission electron microscopy of diamond: A review

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