Biocomposite Hydrogels with Carboxymethylated, Nanofibrillated Cellulose Powder for Replacement of the Nucleus Pulposus

Eyholzer, Christian; Couraça, Ana Borges de; Duc, Fabien; Bourban, P.-E.; Tingaut, Philippe; Zimmermann, Tanja; Månson, J.‐A. E.; Oksman, Kristiina

doi:10.1021/bm101131b

Cited by 107 publications

(56 citation statements)

References 40 publications

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“…The water content of the NP ranges from 65 to 90% [22], which is similar to the values of 60 to 85% obtained in the present case and is crucial for the overall mechanical response of disc [23,24]. As described in detail elsewhere [25][26][27], the present T3/NVP hydrogels have been demonstrated to be biocompatible, and compression tests on hydrated specimens indicate viscoelastic behavior comparable with that of human nucleus pulposus, confirming this system to be an excellent candidate for intervertebral disc repair. (Table 1).…”

Section: Discussionsupporting

confidence: 84%

Synthesis and Photopolymerization of Tween 20 Methacrylate/N-vinyl-2-Pyrrolidone Blends

Borges

Jayakrishnan

Bourban

et al. 2012

Materials Science and Engineering: C

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Poly(oxyethylene 20 sorbitan) monolaurate (Tween® 20) methacrylates were synthesized by coupling methacryloyl chloride (MeOCl) to Tween 20 in the presence of 4-(N,N-dimethylamino) pyridine, using THF as a solvent, in order to investigate their suitability as precursors for photopolymerizable hydrogels in tissue engineering applications. The degree of substitution could be controlled by adjusting the molar ratio of MeOCl and Tween 20, giving three different monomers: Tween 20 monomethacrylate, Tween 20 dimethacrylate and Tween 20 trimethacrylate. Combined 1 H NMR and MALDI-TOF MS confirmed these monomers to be of high purity and to have polydispersities less than 1.3. It was shown that aqueous solutions of the monomers were photoactive, all the methacrylate groups reacting within 30 minutes exposure to a UV light intensity of 145 mW/cm 2 . Aqueous Tween 20 trimethacrylate was then combined with N-vinyl-2-pyrrolidone (NVP), giving tough copolymer hydrogels on photopolymerization, whose swelling ratios and swelling rates could be tuned by varying the Tween 20 trimethacrylate content. The use of a flexible spacer with a multifunctional monomer gives a permanent three-dimensional network, whilst maintaining degrees of swelling of between 60 and 85%, with potential for a wide range of biological and non-biological applications.

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Section: Discussionsupporting

confidence: 84%

Synthesis and Photopolymerization of Tween 20 Methacrylate/N-vinyl-2-Pyrrolidone Blends

Borges

Jayakrishnan

Bourban

et al. 2012

Materials Science and Engineering: C

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“…The size of the NFC fibers has been studied previously using cryo-scanning electron microscopy. 26 However, the results are partially controversial: (1) the fiber size (diameters and length) were not uniform and (2) the fibers also agglomerate. The filament diameter was estimated to be between a few and ∼100 nm.…”

Section: In Situ Photopolymerization Monitoring Resultsmentioning

confidence: 99%

Miniature probe for the delivery and monitoring of a photopolymerizable material

et al. 2015

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Abstract. Photopolymerization is a common method to cure materials initially in a liquid state, such as dental implants or bone or tissue fillers. Recent advances in the development of biocompatible gel-and cement-systems open up an avenue for in situ photopolymerization. For minimally invasive surgery, such procedures require miniaturized surgical endoscopic probes to activate and control photopolymerization in situ. We present a miniaturized light probe in which a photoactive material can be (1) mixed, pressurized, and injected, (2) photopolymerized/photoactivated, and (3) monitored during the chemical reaction. The device is used to implant and cure poly(ethylene glycol) dimethacrylate-hydrogel-precursor in situ with ultraviolet A (UVA) light (365 nm) while the polymerization reaction is monitored in real time by collecting the fluorescence and Raman signals generated by the 532-nm excitation light source. Hydrogels could be delivered, photopolymerized, and monitored by the probe up to a curing depth of 4 cm. The size of the photopolymerized samples could be correlated to the fluorescent signal collected by the probe, and the reproducibility of the procedure could be demonstrated. The position of the probe tip inside a bovine caudal intervertebral disc could be estimated in vitro based on the collected fluorescence and Raman signal. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…[47] Indeed, CNF has been investigated to replace the nucleus pulposus (inner core of the vertebral disc) as well as to stabilize and control the delivery of protein-coated drugs. [48,49]. But their usefulness goes beyond exploiting their electrical reactance in electrical circuits.…”

Section: Cellulose Nanofibersmentioning

confidence: 99%

Upscaling Organic Electronic Devices

Malti¹

2015

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Conventional electronics based on silicon, germanium, or compounds of gallium require prohibitively expensive investments. A state-of-the-art microprocessor fabrication facility can cost up to $15 billion while using environmentally hazardous processes. In that context, the discovery of solution-processable conducting (and semiconducting) polymers stirred up expectations of ubiquitous electronics because it enables the mass-production of devices using well established high-volume printing techniques. In essence, this thesis attempts to study the characteristics and applications of thin conducting polymer films (<200 nm), and scale them up to thick-films (>100 µm). First, thin-films of organic materials were combined with an electric double layer capacitor to decrease the operating voltage of organic field effect transistors. In addition, ionic current-rectifying diodes membranes were integrated inside electrochromic displays to increase the device's bistability and obviate the need for an expensive addressing backplane.This work also shows that it is possible to forgo the substrate and produce a self-standing electrochromic device by compositing the same water-processable material with nanofibrillated cellulose (plus a whitening pigment and high-boiling point solvents). In addition, we investigated the viability of these (semi)conducting polymer nanopaper composites in a variety of applications. This material exhibited an excellent combined electronic-ionic conductivity. Moreover, the conductivities in this easy-to-process composite remained constant within a wide range of thicknesses. Initially, this (semi)conducting nanopaper composite was used to produce electrochemical transistors with a giant transconductance (>1 S). Subsequently, it was used as electrodes to construct a supercapacitor whose capacitance exceeds 1 F.

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Biocomposite Hydrogels with Carboxymethylated, Nanofibrillated Cellulose Powder for Replacement of the Nucleus Pulposus

Cited by 107 publications

References 40 publications

Synthesis and Photopolymerization of Tween 20 Methacrylate/N-vinyl-2-Pyrrolidone Blends

Synthesis and Photopolymerization of Tween 20 Methacrylate/N-vinyl-2-Pyrrolidone Blends

Miniature probe for the delivery and monitoring of a photopolymerizable material

Upscaling Organic Electronic Devices

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