Bioconcentration and distribution of 4-tert-octylphenol residues in tissues of the rainbow trout (Oncorhynchus mykiss)

Ferreira-Leach, A. M. R.; Hill, Elizabeth M.

doi:10.1016/s0141-1136(00)00256-7

Cited by 93 publications

(57 citation statements)

References 41 publications

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“…In rainbow trout, approximately 90% of estradiol is excreted as E2-glucuronide (17). For the xenoestrogen 4-tert-octylphenol it was observed that, after a 10-d exposure, 38% of the total accumulation in the body of rainbow trout was found back in the bile, present as glucuronides (18). A major pathway of elimination is excretion via bile into the intestines.…”

Section: Introductionmentioning

confidence: 99%

Identification of Estrogenic Compounds in Fish Bile Using Bioassay-Directed Fractionation

Houtman

Oostveen

Brouwer

et al. 2004

Environ. Sci. Technol.

151

118

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Conjugates of estrogenic chemicals, endogenous as well as xenobiotic, are mainly excreted via bile into the intestine. Therefore, measurement of estrogenic activity in bile yields useful information about an organism's internal exposure to (xeno-)estrogens. Although previous studies in The Netherlands have reported estrogenic activity in male fish bile, the contribution of natural hormones and xenobiotic substances to this activity is unknown. To identify compounds responsible for estrogenic activity in fish bile, we developed a bioassay-directed fractionation method for estrogenic chemicals. In this approach, the in vitro reporter gene assay ER-CALUX (Estrogen Responsive Chemical Activated Luciferase Gene Expression) was used to assess estrogenic activity in deconjugated bile samples and to direct RP-HPLC fractionation and chemical analysis (by GC−MS) of estrogenic compounds. The method was applied to bile from male breams (Abramis brama) collected at three locations in The Netherlands. At one of these locations, the River Dommel, extremely high levels of plasma vitellogenin and a high incidence of intersex gonads in these male breams have previously been observed, indicating the exposure to estrogens. In this study, the natural hormones 17β-estradiol, estrone, and estriol accounted for the majority of estrogenic activity in male bream bile. At the River Dommel, the synthetic contraceptive pill component ethynylestradiol was found in effective concentrations as well. The detected natural and synthetic hormones may be responsible for the estrogenic effects observed in wild bream from this location. Furthermore, a large number of xenobiotic chemicals was detected at relatively high levels in bile, including triclosan, chloroxylenol, and clorophene. Although chloroxylenol was shown for the first time to be weakly estrogenic, these compounds did not contribute significantly to the estrogenic activity observed.

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Section: Introductionmentioning

confidence: 99%

Identification of Estrogenic Compounds in Fish Bile Using Bioassay-Directed Fractionation

Houtman

Oostveen

Brouwer

et al. 2004

Environ. Sci. Technol.

151

118

View full text Add to dashboard Cite

show abstract

“…On the other hand, uptake through skin and gills was also demonstrated (Ferreira-Leach and Hill 2001). A distribution of APs in live organisms was also investigated and, due to partly lipophilic nature of APs, their target tissues in fish (such as the adipose tissue, brain, liver, kidney, muscle, skin and eye) are rich in grease (Ferreira-Leach and Hill 2001). The study, using radio-labelled compounds demonstrating their distribution, indicates that the liver and bile are a main excretion route for absorbed APs, and the concentration of AP metabolites excreted in bile increased with increasing degree of alkylation.…”

Section: Occurrence In Biological Matricesmentioning

confidence: 98%

“…These findings revealed that the main source of APs for marine organisms is not water column and intake through gills but sediments and dietary uptake, both depending on the AP distribution in the aquatic environment. On the other hand, uptake through skin and gills was also demonstrated (Ferreira-Leach and Hill 2001). A distribution of APs in live organisms was also investigated and, due to partly lipophilic nature of APs, their target tissues in fish (such as the adipose tissue, brain, liver, kidney, muscle, skin and eye) are rich in grease (Ferreira-Leach and Hill 2001).…”

Section: Occurrence In Biological Matricesmentioning

confidence: 99%

Alkylphenol ethoxylates and alkylphenols – update information on occurrence, fate and toxicity in aquatic environment

Kovářová

Blahová

Divišová

et al. 2013

Polish Journal of Veterinary Sciences

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Alkylphenols and their precursors, alkylphenol etoxylates, are a group of manmade chemicals used mainly as surfactants in domestic and industrial applications worldwide. It has been well established that they have endocrine disruption activity, hepatotoxic, genotoxic and other negative effects on animal and human health. In spite of the effort to reduce their use, they persist in the environment not only in industrial but also in remote regions, and were detected in the variety of natural matrices including air, water, soil as well as food products, and human blood and urine worldwide. This article summarizes their occurrence, fate in natural conditions, and toxicity including mode of action. A subject of our concern was the aquatic environment as the most important reservoir and target of their deleterious impact.

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“…Kontzentrazioak toxikotasun-mailakoak baino baxuagoak diren bitartean, balio horiek ez lukete arriskurik ekarri beharko. Alabaina, etengabeko esposizioak arazoak ekar ditzake uretan bizi diren espezieetan [16,27,28]. Arrainek konposatu toxikoak barneratzeko 3 bide nagusi dituzte: elikadura, larruazala eta arnasketa.…”

Section: Konposatu Kimikoak Biota-laginetanunclassified

“…Esperimentalki kalkulatu diren BCF gehienak muskulu-laginei dagozkie; azken finean, hau baita gizakiok jaten dugun atala. Oro har, BCF faktoreak nahiko baxuak dira muskuluan [20,27,52,73], betiere Lee eta haren lankideek [73] proposatzen duten 1.000 baliotik beherakoak, konposatu eta arrain-espezie desberdinetarako. Kontrako muturrean behazunean kalkulatutako BCFak daude.…”

Section: Ekuazioaunclassified

Konposatu disruptore endokrinoen azterketa kimika analitikoaren ikuspuntutik

Ros¹,

Vallejo²,

Olivares³

et al. 2018

EKAIA

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Laburpena: Ingurumeneko uretan kutsatzaile organiko desberdinak aurkitzen dira, nahiz eta kontzentrazio baxuetan izan (ng/L mailan). Araztegien irteera korronteak izan ohi dira konposatu horien iturririk nagusietako bat, araztegiek erabiltzen dituzten mekanismoak ez baitira gai kutsatzaileen arazketa osoa burutzeko. Horien artean, konposatu disruptore endokrino (EDC) izenez ezagutzen diren konposatuak aurki daitezke, eta horiek ingurumenean bizi diren espezieetan aldaketa endokrinoak sor ditzakete, nahiz eta EDCak kontzentrazio baxuetan egon. Kalte horien artean, malformazioak, populazioen aldaketak edo intersexualitatea dira nabarmenenak. Hau guztia ikusirik, kimika analitikoaren ikuspuntutik oso garrantzitsua da metodo analitiko sentikorrak garatzea konposatuak ur-eta biota-laginetatik erauzi eta garbitzeko, bai eta konposatuek biotaren atal desberdinetan metatzeko duten joera aztertzeko ere.Hitz gakoak: konposatu disruptore endokrinoak, erauzketa-metodoak, biokontzentrazioa, ur-laginak, biota.Abstract: There are several organic contaminants present in the aquatic environment, even they are find at very low concentrations (ng/L level). The effluents of the wastewater treatment plants (WWTP) can be one of the main sources into the environment, since the mechanism used by the WWTP are not fully efective for the complete removal of the contaminants. Among them, some of them are classified as endocrine disrupting compounds (EDCs) and they can provoke endocrine alterations in the species habiting in the water even they are found at low concentrations. Malformations, a decrease on the polulation or intersexuality are the most significant damages. Thus, the development of highly sensitive analytical methods for the extraction and clean-up of the water and biota samples is vital from an analytical point of view together with the accumulation capacity of the compounds in the different biota compartments.

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Bioconcentration and distribution of 4-tert-octylphenol residues in tissues of the rainbow trout (Oncorhynchus mykiss)

Cited by 93 publications

References 41 publications

Identification of Estrogenic Compounds in Fish Bile Using Bioassay-Directed Fractionation

Identification of Estrogenic Compounds in Fish Bile Using Bioassay-Directed Fractionation

Alkylphenol ethoxylates and alkylphenols – update information on occurrence, fate and toxicity in aquatic environment

Konposatu disruptore endokrinoen azterketa kimika analitikoaren ikuspuntutik

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