Bioconcentration by Fish of a Highly Volatile Silicone Compound in a Totally Enclosed Aquatic Exposure System

Fackler, Paul; Dionne, Emily; Hartley, Deborah A.; Hamelink, Jerry L.

doi:10.1897/1552-8618(1995)14[1649:bbfoah]2.0.co;2

Cited by 4 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Due to its widespread application in consumer applications, D 4 has been subjected to a number of environmental fate and effects studies as well as toxicological testing (1)(2)(3)(4)(5). D 4 also prompted aquatic and environmental fate testing as the focus of a TSCA Section 4 Consent Order in 1988.…”

mentioning

confidence: 99%

Extraction of Octamethylcyclotetrasiloxane and Its Metabolites from Biological Matrices

Varaprath

Salyers

Plotzke

et al. 1998

Analytical Biochemistry

View full text Add to dashboard Cite

mentioning

confidence: 99%

Extraction of Octamethylcyclotetrasiloxane and Its Metabolites from Biological Matrices

Varaprath

Salyers

Plotzke

et al. 1998

Analytical Biochemistry

View full text Add to dashboard Cite

“…Under this CO, a comprehensive aquatic toxicity and environmental fate testing program was sponsored by the Silicones Environmental Health and Safety Council. These study results are published elsewhere (Kent et al, 1994;Fackler et al, 1995;Hobson, 1995;Hobson and Silberhorn, 1995;Sousa et al, 1995). The current paper describes only the results and interpretation of the biodegradation study.…”

Section: Ntroducti 0 Nmentioning

confidence: 74%

Interpretation of data from nonstandard studies: The fate of octamethylcyclotetrasiloxane in a sediment/water microcosm system

Kent¹,

Fackler

Hartley

et al. 1996

Environ. Toxicol. Water Qual.

View full text Add to dashboard Cite

“…These modeled bioaccumulation values do not take into account any potential metabolism of D5 to other compounds. However, an experimental BCF study with D4 (Fackler et al, 1995) suggests that metabolism of D4 in fish is probably not significant, and therefore D5 may also not be significantly metabolized in fish. Environment Canada (2007) found the weight of evidence indicated that D5 meets the bioaccumulation criterion (BCF, BAF > 5,000) as set out in the Persistence and Bioaccumulation Regulations (Government of Canada 2000).…”

Section: Potential For Bioaccumulationmentioning

confidence: 99%

Distribution, Elimination, and Rearrangement of Cyclic Volatile Methylsiloxanes in Oil-Contaminated Soil of the Shengli Oilfield, China

Shi

et al. 2015

Environ. Sci. Technol.

View full text Add to dashboard Cite

SUBJECT: REVIEW OF TOXICITY INFORMATION ON D5 ______________________________________________________________________________We are forwarding our review of available information on the toxicity and persistence of decamethylcyclopentasiloxane (D5), a proposed alternative for perchloroethylene in dry cleaning. The review was conducted to provide ARB with information on which to base a determination of whether D5 could be considered a non-toxic alternative to perchloroethylene for dry cleaning under AB 998 (Lowenthal, Chapter 821, Statutes of 2003), pursuant to contract number 05-414. In response to your request to evaluate available information on the toxicity of D5 under the statutory mandate, OEHHA staff have reviewed information submitted by the Silicones Environmental Health and Safety Council (SEHSC), including studies evaluating acute and subchronic toxicity, neuroendocrine activity, estrogenicity, genotoxicity, chronic toxicity and carcinogenicity and related mode of action studies, and pharmacokinetics. In addition, we evaluated an SEHSC white paper summarizing the toxicity of D5, and an exposure assessment conducted by Environ Corporation for SEHSC. We also searched the open literature for additional information, including government documents from other countries, and identified additional information on human exposure, environmental persistence and accumulation in biota. As requested by ARB, we focused on evaluating the applicability of the SEHSC-proposed mechanism of action of tumor formation in rodents to human health risk assessment. Our review of the available information is attached.In the process of reviewing the information, we met three times with the SEHSC representatives, including their toxicologists. We sought outside expertise from the University of California, Davis, regarding the merits of the proposed mode of action of D5 induced tumors in rodents. We also spoke with U.S.EPA scientists, who reviewed materials on D5 toxicity under

show abstract

Bioconcentration by Fish of a Highly Volatile Silicone Compound in a Totally Enclosed Aquatic Exposure System

Cited by 4 publications

References 0 publications

Extraction of Octamethylcyclotetrasiloxane and Its Metabolites from Biological Matrices

Extraction of Octamethylcyclotetrasiloxane and Its Metabolites from Biological Matrices

Interpretation of data from nonstandard studies: The fate of octamethylcyclotetrasiloxane in a sediment/water microcosm system

Distribution, Elimination, and Rearrangement of Cyclic Volatile Methylsiloxanes in Oil-Contaminated Soil of the Shengli Oilfield, China

Contact Info

Product

Resources

About