Bioconcentration, metabolism and toxicity of substituted anilines in the zebrafish (Brachydanio rerio)

Zok, Sabine; Görge, Gerhard; Kalsch, Wolfgang; Nagel, Roland

doi:10.1016/0048-9697(91)90196-l

Cited by 65 publications

(25 citation statements)

References 14 publications

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“…limit or below measured "sh CBRs reported for other polar organics (i.e., substituted phenols, nitrobenzenes, pyridines, and aliphatic and aromatic amines) which are in the range of 0.5}4.6 mmol/kg (Deneer et al, 1987;Zok et al, 1991;Ramos et al, 1998). In contrast, calculated CBRs for total (parent#metabolite) PE (using BCFs based on total radioactivity) are much higher than CBRs derived from PE QSARs for "sh and daphnids but are in agreement for algae (Table 6).…”

Section: Discussionmentioning

confidence: 99%

Application of Quantitative Structure–Activity Relationships for Assessing the Aquatic Toxicity of Phthalate Esters

Parkerton¹,

Konkel

2000

Ecotoxicology and Environmental Safety

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Section: Discussionmentioning

confidence: 99%

Application of Quantitative Structure–Activity Relationships for Assessing the Aquatic Toxicity of Phthalate Esters

Parkerton¹,

Konkel

2000

Ecotoxicology and Environmental Safety

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“…c 2007 Wiley Periodicals, Inc. important compounds such as dyes, agrochemicals, pharmaceutical agents, etc. [1]. They are distributed in an aqueous environment and cause teratosis in aquatic species [2].…”

Section: Organic Amines and Their Derivatives Are Used As Intermediatmentioning

confidence: 99%

Solvent and substituent effects on the electrochemical oxidation of substituted benzylamines in 2‐methylpropan‐2‐ol/water medium

Thirumoorthi

Elango

2007

Int J of Chemical Kinetics

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Electrochemical oxidation of various para-and meta-substituted benzylamines in different mole fractions of 2-methylpropan-2-ol in water has been investigated in the presence of 0.1 M sulfuric acid as supporting electrolyte. The oxidation potential data of benzylamines correlates well with Hammett's substituent constants affording negative reaction constants (−1.112 < ρ > −1.529). The correlation of the oxidation potential values with macroscopic solvent parameters is nonlinear, suggesting the operation of both specific and nonspecific solvent-solvent-solute interaction mechanisms. Correlation of the experimental data with Kamlet-Taft solvatochromic parameters is excellent (100r 2 > 98%) and the results reveal that the reactivity is influenced by the preferential solvational effects.

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“…[18][19][20][21][22] ). Examples include the use of adult zebrafish for the testing of lead and uranium, 23 malathion, 24 colchicine, 25 anilines, 26 and metronidazole, 27 and the use of juveniles and embryos for testing agricultural biocides. 28,29 Not only adult zebrafish, but also zebrafish embryos or larvae are used in toxicity studies (reviewed by Truong et al 30 ).…”

Section: Introductionmentioning

confidence: 99%

Teratological Effects of a Panel of Sixty Water-Soluble Toxicants on Zebrafish Development

2014

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The zebrafish larva is a promising whole-animal model for safety pharmacology, environmental risk assessment, and developmental toxicity. This model has been used for the high-throughput toxicity screening of various compounds. Our aim here is to identify possible phenotypic markers of teratogenicity in zebrafish embryos that could be used for the assaying compounds for reproductive toxicity. We have screened a panel of 60 water-soluble toxicants to examine their effects on zebrafish development. A total of 22,080 wild-type zebrafish larvae were raised in 250 lL defined buffer in 96-well plates at a plating density of one embryo per well. They were exposed for a 96-h period starting at 24 h post-fertilization. A logarithmic concentration series was used for range-finding, followed by a narrower geometric series for developmental toxicity assessment. A total of 9017 survivors were analyzed at 5 days post-fertilization for nine phenotypes, namely, (1) normal, (2) pericardial oedema, (3) yolk sac oedema, (4) melanophores dispersed, (5) bent tail tip, (6) bent body axis, (7) abnormal Meckel's cartilage, (8) abnormal branchial arches, and (9) uninflated swim bladder. For each toxicant, the EC 50 (concentration required to produce one or more of these abnormalities in 50% of embryos) was also calculated. For the majority of toxicants (55/60) there was, at the population level, a statistically significant, concentration-dependent increase in the incidence of abnormal phenotypes among survivors. The commonest abnormalities were pericardial oedema, yolk sac oedema, dispersed melanophores, and uninflated swim bladder. It is possible therefore that these could prove to be general indicators of reproductive toxicity in the zebrafish embryo assay.

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Bioconcentration, metabolism and toxicity of substituted anilines in the zebrafish (Brachydanio rerio)

Cited by 65 publications

References 14 publications

Application of Quantitative Structure–Activity Relationships for Assessing the Aquatic Toxicity of Phthalate Esters

Application of Quantitative Structure–Activity Relationships for Assessing the Aquatic Toxicity of Phthalate Esters

Solvent and substituent effects on the electrochemical oxidation of substituted benzylamines in 2‐methylpropan‐2‐ol/water medium

Teratological Effects of a Panel of Sixty Water-Soluble Toxicants on Zebrafish Development

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