Biocontrol treatment: Application of Bdellovibrio bacteriovorus HD100 against burn wound infection caused by Pseudomonas aeroginosa in mice

Tajabadi, Fereshteh Heidari; Karimian, Seyed Morteza; Mohsenipour, Zeinab; Mohammadi, Sahar; Salehi, Mohammadreza; Sattarzadeh, Mahboubeh; Fakhari, Sima; Momeni, Maryam; Dahmardehei, Mohammad; Feizabadi, Mohammad Mehdi

doi:10.1016/j.burns.2022.08.020

Cited by 9 publications

(2 citation statements)

References 57 publications

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“…It has been demonstrated that Bdellovibrio bacteriovorus are indifferent to the antibiotic-resistance status of their prey [6,7]. Moreover, it has been demonstrated that predatory bacteria are nontoxic to mammalian cells and in animal models and have the ability to attenuate Gram-negative bacteria in several in vivo models, including but not limited to airway and oral infections in rodents and central nervous system infection of zebrafish hindbrain ventricles [8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Predatory bacteria prevent the proliferation of intraocular Serratia marcescens and fluoroquinolone-resistant Pseudomonas aeruginosa

Romanowski,

Brothers,

Calvario

et al. 2024

Microbiology

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Endogenous endophthalmitis caused by Gram-negative bacteria is an intra-ocular infection that can rapidly progress to irreversible loss of vision. While most endophthalmitis isolates are susceptible to antibiotic therapy, the emergence of resistant bacteria necessitates alternative approaches to combat intraocular bacterial proliferation. In this study the ability of predatory bacteria to limit intraocular growth of Pseudomonas aeruginosa, Serratia marcescens, and Staphylococcus aureus was evaluated in a New Zealand white rabbit endophthalmitis prevention model. Predatory bacteria Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus were able to reduce proliferation of keratitis isolates of P. aeruginosa and to a lesser extent S. marcescens. However, it was not able to significantly reduce the number of intraocular S. aureus, which is not a productive prey for these predatory bacteria, suggesting that the inhibitory effect on P. aeruginosa and S. marcescens requires active predation rather than an antimicrobial immune response. Similarly, UV-inactivated B. bacteriovorus were unable to prevent proliferation of P. aeruginosa. Together, these data indicate in vivo inhibition of Gram-negative bacteria proliferation within the intra-ocular environment by predatory bacteria.

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Section: Introductionmentioning

confidence: 99%

Predatory bacteria prevent the proliferation of intraocular Serratia marcescens and fluoroquinolone-resistant Pseudomonas aeruginosa

Romanowski,

Brothers,

Calvario

et al. 2024

Microbiology

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show abstract

“…It has been demonstrated that predatory bacteria are indifferent to the antibiotic-resistance status of their prey [6,7]. Moreover, it has been demonstrated that predatory bacteria are non-toxic to mammalian cells and in animal models and have the ability to attenuate Gram-negative bacteria several in vivo models, including but not limited to airway and oral infections in rodents and central nervous system infection of zebrafish hindbrain ventricles [8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Intra-ocular Predation of Fluoroquinolone-ResistantPseudomonas aeruginosaandSerratia marcescensby Predatory Bacteria

Romanowski,

Brothers,

Calvario

et al. 2023

Preprint

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Endogenous endophthalmitis caused by Gram-negative bacteria is an intra-ocular infection that can rapidly progress to irreversible loss of vision. While most endophthalmitis isolates are susceptible to antibiotic therapy, the emergence of resistant bacteria necessitates alternative approaches to combat intraocular bacterial proliferation. In this study the ability of predatory bacteria to limit intraocular growth of Pseudomonas aeruginosa, Serratia marcescens, and Staphylococcus aureus was evaluated in a New Zealand White rabbit endophthalmitis prevention model. Predatory bacteria Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus were able to reduce proliferation of keratitis isolates of P. aeruginosa and S. marcescens. However, it was not able to significantly reduce S. aureus, which is not a productive prey for these predatory bacteria, suggesting that the inhibitory effect on P. aeruginosa requires active predation rather than an antimicrobial immune response. Similarly, UV-inactivated B. bacteriovorus were unable to prevent proliferation of P. aeruginosa. Together, these data suggest in vivo predation of Gram-negative bacteria within the intra-ocular environment.

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Predatory bacteria as potential biofilm control and eradication agents in the food industry

Mun

Choi

Upatissa

et al. 2023

Food Sci Biotechnol

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Biocontrol treatment: Application of Bdellovibrio bacteriovorus HD100 against burn wound infection caused by Pseudomonas aeroginosa in mice

Cited by 9 publications

References 57 publications

Predatory bacteria prevent the proliferation of intraocular Serratia marcescens and fluoroquinolone-resistant Pseudomonas aeruginosa

Predatory bacteria prevent the proliferation of intraocular Serratia marcescens and fluoroquinolone-resistant Pseudomonas aeruginosa

Intra-ocular Predation of Fluoroquinolone-ResistantPseudomonas aeruginosaandSerratia marcescensby Predatory Bacteria

Predatory bacteria as potential biofilm control and eradication agents in the food industry

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