Biodegradability, antimicrobial activity and properties of PVA/PVP hydrogels prepared by γ-irradiation

El‐Mohdy, H. L. Abd; Ghanem, Samah

doi:10.1007/s10965-008-9196-0

Cited by 143 publications

(57 citation statements)

References 57 publications

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“…By mixing PVA with other natural [4,5] or synthetic [6] polymers, new composites can be obtained which synergetically combines the properties of individual components. In order to prepare materials for biomedical applications, an interesting partner for PVA is PVP [7][8][9][10]. This polymer has a long history in pharmaceutical and medical fields, being encountered in various forms as films, nanofibres or hydrogels for medical devices, drug delivery systems, contact lenses, orthopedics, dentistry, and many others [11].…”

Section: Introductionmentioning

confidence: 99%

“…The hydrogels can be obtained using different chemical or physical methods [1][2][3][4][5][6][7][8][9][10][14][15][16][17][18][19][20][21][22][23][24][25]. Chemical crosslinking provides a more controllable network structure with uniform pore sizes but requires a careful purification step to remove the free unreacted crosslinker, initiator or monomers with potential toxicity.…”

Section: Introductionmentioning

confidence: 99%

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Rheological investigation of poly(vinyl alcohol)/poly(N-vinyl pyrrolidone) mixtures in aqueous solution and hydrogel state

2016

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Rheological behavior of poly(vinyl alcohol) (PVA) and poly(N-vinyl pyrrolidone) (PVP) mixtures in aqueous solutions and hydrogel state was investigated. The complex dependence of the viscosity on PVA/PVP mixture composition could be attributed to cumulative effects of electrostatic interactions, hydrogen bonding or association phenomena. Physical hydrogels were prepared by freezing/thawing method and their viscoelastic properties were followed as a function of number of cryogenic cycles and aging time at 37°C. From swelling experiments, it was observed that the diffusion of water molecules into the hydrogel pores is Fickian (for low number of cryogenic cycles) and it becomes pseudo-Fickian as the sample is submitted to more than 10 freezing/thawing cycles. PVA/PVP hydrogels obtained by physical interactions present a high degree of tailorability and they are suitable candidates for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rheological investigation of poly(vinyl alcohol)/poly(N-vinyl pyrrolidone) mixtures in aqueous solution and hydrogel state

2016

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“…PVP is another hydrogel that has been used for a variety of biomedical applications due to its good biocompatibility and hydrophilic ability properties [28,29]. The incorporation of PVP into PVA is expected to significantly decrease degradation and stabilize the polymer network and the mechanical properties of pure PVA hydrogels through hydrogen bonding interactions between the carbonyl group on PVP and the hydroxyl group along PVA chain [30]. Leone et al [31] has demonstrated the biocompatibility of PVA/PVP hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Effects of polymerization degree on recovery behavior of PVA/PVP hydrogels as potential articular cartilage prosthesis after fatigue test

Yan¹,

Xiong²,

Peng³

et al. 2016

Express Polym. Lett.

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Abstract. Poly (vinyl alcohol)/poly (vinyl pyrrolidone) (PVA/PVP) hydrogels with various polymerization degrees of PVA were synthesized by a repeated freezing-thawing method. The influence of polymerization degree on microstructure, water content, friction coefficient, compressive fatigue and recovery properties of PVA/PVP hydrogels were investigated. The results showed that higher polymerization degree resulted in larger compressive modulus and lower friction coefficient. The fatigue behaviors of PVA/PVP hydrogels were evaluated under sinusoidal compressive loading from 200 to 800 N at 5 Hz for up to 50 000 cycles. The unconfined uniaxial compressive tests of PVA/PVP hydrogels were performed before and after fatigue test. During the fatigue test, the height of the hydrogel rapidly decreased at first and gradually became stable with loading cycles. The compressive tangent modulus measured 0 h after fatigue was significantly larger than the values obtained before test, and then the modulus recovered to its original level for 48 h after test. However, the geometry of hydrogels could not return to the original level due to the creep effects. PVA/PVP hydrogels prepared with lower polymerization degree showed better recovery capability than that prepared with high polymerization degree.

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“…Abd El-Mohdy and Ghan [7], describe biodegradation of PVP in a soil environment (soil burial test). Their findings of a decrease in mass does not evidence the complete resilience of pure PVP, as regards decomposition, with such mass dropping to about 10% after 6 months.…”

Section: Introductionmentioning

confidence: 99%

Initiating Biodegradation of Polyvinylpyrrolidone in an Aqueous Aerobic Environment: Technical Note / Zainicjowanie Biodegradacji Poliwinylopirolidonu W Środowisku Wodno-Tlenowym: Notatki Techniczne

Julinová

Kupec

Slavík

et al. 2013

Ecological Chemistry and Engineering S

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A synthetic polymer, polyvinylpyrrolidone (PVP -E 1201) primarily finds applications in the pharmaceutical and food industries due to its resistance and zero toxicity to organisms. After ingestion, the substance passes through the organism unchanged. Consequently, it enters the systems of municipal wastewater treatment plants (WWTP) without decomposing biologically during the waste treatment process, nor does it attach (through sorption) to particles of activated sludge to any significant extent, therefore, it passes through the system of a WWTP, which may cause the substance to accumulate in the natural environment. For this reason the paper investigates the potential to initiate aerobic biodegradation of PVP in the presence of activated sludge from a municipal wastewater treatment plant. The following agents were selected as the initiators of the biodegradation process -co-substrates: acrylamide, N-acethylphenylalanine and 1-methyl-2-pyrrolidone, a substance with a similar structure to PVP monomer. The biodegradability of PVP in the presence of co-substrates was evaluated on the basis of biological oxygen demand (BOD) as determined via a MicroOxymax O2/CO2/CH4 respirometer. The total substrate concentration in the suspension equaled 400 mg·dm -3 , with the ratio between PVP and the cosubstrate being 1:1, while the concentration of the dry activated sludge was 500 mg·dm -3 . Even though there was no occurrence of a significant increase in the biodegradation of PVP alone in the presence of a co-substrate, acrylamide appeared to be the most effective type of co-substrate. Nevertheless, a recorded decrease in the slope of biodegradation curves over time may indicate that a process of primary decomposition was underway, which involves the production of metabolites that inhibit activated sludge microorganisms. The resulting products are not identified at this stage of experimentation.

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Biodegradability, antimicrobial activity and properties of PVA/PVP hydrogels prepared by γ-irradiation

Cited by 143 publications

References 57 publications

Rheological investigation of poly(vinyl alcohol)/poly(N-vinyl pyrrolidone) mixtures in aqueous solution and hydrogel state

Rheological investigation of poly(vinyl alcohol)/poly(N-vinyl pyrrolidone) mixtures in aqueous solution and hydrogel state

Effects of polymerization degree on recovery behavior of PVA/PVP hydrogels as potential articular cartilage prosthesis after fatigue test

Initiating Biodegradation of Polyvinylpyrrolidone in an Aqueous Aerobic Environment: Technical Note / Zainicjowanie Biodegradacji Poliwinylopirolidonu W Środowisku Wodno-Tlenowym: Notatki Techniczne

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