Biodegradability of sol–gel silica microparticles for drug delivery

Finnie, Kim S.; Waller, Daniel J.; Perret, Francois L.; Krause‐Heuer, Anwen M.; Lin, Hui; Hanna, John V.; Barbé, C.

doi:10.1007/s10971-008-1847-4

Cited by 140 publications

(105 citation statements)

References 13 publications

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“…Using inverse recomputation according to equation (1), it is possible to derive the value which corresponds to 95% biodegradation of silica, which is 41 days. These data fit well with the results of Finnie et al 19 who studied biodegradation of sol-gel mesoporous silica microparticles and showed that silica microparticles are rapidly degraded in physiological buffer. Further, the authors demonstrated that addition of plasma proteins to the buffer retarded biodegradation by 20%-30%.…”

Section: Biodegradation Of Silica Nanoparticles In Vitro and In Vivosupporting

confidence: 90%

Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

Galagudza¹,

Королев²,

Постнов³

et al. 2012

IJN

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Pharmacological agents suggested for infarct size limitation have serious side effects when used at cardioprotective doses which hinders their translation into clinical practice. The solution to the problem might be direct delivery of cardioprotective drugs into ischemic-reperfused myocardium. In this study, we explored the potential of silica nanoparticles for passive delivery of adenosine, a prototype cardioprotective agent, into ischemic-reperfused heart tissue. In addition, the biodegradation of silica nanoparticles was studied both in vitro and in vivo. Immobilization of adenosine on the surface of silica nanoparticles resulted in enhancement of adenosine-mediated infarct size limitation in the rat model. Furthermore, the hypotensive effect of adenosine was attenuated after its adsorption on silica nanoparticles. We conclude that silica nanoparticles are biocompatible materials that might potentially be used as carriers for heart-targeted drug delivery.

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Section: Biodegradation Of Silica Nanoparticles In Vitro and In Vivosupporting

confidence: 90%

Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

Galagudza¹,

Королев²,

Постнов³

et al. 2012

IJN

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show abstract

“…With use of mathematical analysis, we derived the value which corresponds to 95% biodegradation of silica and equals to 41 day. These data fit well to the results of Finnie et al (2009) who studied biodegradation of sol-gel mesoporous silica microparticles. It has been shown in this study that silica microparticles are rapidly degraded in physiological buffer.…”

Section: Fig 2 Hypothetical Mechanism Of Silica Nanoparticle Biodegsupporting

confidence: 88%

Cardiac Protection with Targeted Drug Delivery to Ischemic-Reperfused Myocardium

Galagudza¹

2012

Novel Strategies in Ischemic Heart Disease

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“…Quartz is very resistant to hydrolysis and does not biodegrade in physiological environments. Certain forms of high surface area, amorphous mesoporous silica however does show biodegradability whilst others show high stability against hydrolysis [20,21]. It seems likely that amorphous silicon in various structural forms will show much faster biodegradation kinetics to those of both amorphous silica and polycrystalline silicon.…”

Section: Discussionmentioning

confidence: 99%

Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres

Shabir

Pokale

Loni

et al. 2011

Silicon

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Hydrogenated amorphous silicon colloids of low surface area ( <5m 2 /g) are shown to exhibit complete in-vitro biodegradation into orthosilicic acid within 10-15 days at 37°C. When converted into polycrystalline silicon colloids, by high temperature annealing in an inert atmosphere, microparticle solubility is dramatically reduced. The data suggests that amorphous silicon does not require nanoscale porosification for full in-vivo biodegradability. This has significant implications for using a-Si:H coatings for medical implants in general, and orthopaedic implants in particular. The high sphericity and biodegradability of submicron particles may also confer advantages with regards to contrast agents for medical imaging.

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Biodegradability of sol–gel silica microparticles for drug delivery

Cited by 140 publications

References 13 publications

Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles

Cardiac Protection with Targeted Drug Delivery to Ischemic-Reperfused Myocardium

Medically Biodegradable Hydrogenated Amorphous Silicon Microspheres

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