Biodegradable and biocompatible polyampholyte microgels derived from chitosan, carboxymethyl cellulose and modified methyl cellulose

Dhar, N.S.; Akhlaghi, Seyedeh Parinaz; Tam, Kam Chiu

doi:10.1016/j.carbpol.2011.07.022

Cited by 72 publications

(23 citation statements)

References 28 publications

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“…The hydrolysis rate of poly(ethylene glycol)-NHS is relatively slow at near neutral condition (pH 7.4), but it increases 34.2 fold under alkaline conditions (pH 9.0) (Nojima et al, 2009). The optimal pH for amide formation mediated by EDC-NHS is 4-6 (Dhar, Akhlaghi, & Tam, 2012;Nakajima & Ikada, 1995). But the present reaction system is basic with pH higher than 8 due to the inherent basic nature of EDC.…”

Section: Synthesis and Nmr Analysismentioning

confidence: 92%

Modification of chitosan with monomethyl fumaric acid in an ionic liquid solution

Wang

Zheng

et al. 2015

Carbohydrate Polymers

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Section: Synthesis and Nmr Analysismentioning

confidence: 92%

Modification of chitosan with monomethyl fumaric acid in an ionic liquid solution

Wang

Zheng

et al. 2015

Carbohydrate Polymers

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“…These chemical crosslinkers are limited for the applications in biomedical or pharmaceutical areas because of their toxicity or the stimulatory reaction to the encapsulated bioactive molecules or live cells. A bio-based carbodiimide crosslinker has been used to prepare chitosan/CMC microgels [22], indicating a very low efficiency of crosslinking reaction. Another synthetic route is to form CMC gels via functional groups of both components without any crosslinker, for example, hydrazide-functionalized CMC/aldehyde-functionalized dextran, suggested by Kesselman et al [23].…”

Section: Introductionmentioning

confidence: 99%

Preparation of carboxymethyl cellulose based microgels for cell encapsulation

Ke¹,

Liu²,

Wang

et al. 2014

Express Polym. Lett.

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Abstract. Biocompatible and biodegradable carboxymethyl cellulose (CMC) has been modified with 4-hydroxybenzylamine (CMC-Ph) in order to prepare CMC-based microgels through the horseradish peroxidise/hydrogen peroxide enzymatic reaction. CMC-Ph was identified as a blend, and the amount of the grafted 4-hydroxybenzylamine per 100 units of CMC was between 17 and 23 according to the molecular weight of CMC. Through a special designed co-flowing microfluidic device, CMC-Ph microgels were prepared with the radius from 100 to 500 µm via adjusting the flow rates of the disperse phase and the continuous phase, respectively. The chondrocytic cell line ATDC5 was encapsulated in the CMC-Ph microgels. The cell-laden microgels were cultured for up to 40 days, illustrating the biocompatibility of CMC-Ph and the microfluidic approach through the enzymatic crosslinking reaction primarily. CMC-Ph showed a great promise to encapsulate the cells for further fabrication of the injectable scaffolds.

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“…The C@N absorption at 1602 cm 21 in the p-NBD-Gly-Schiff base and p-ABD-Gly-Schiff base 22 showed that the target of Schiff base was successfully synthesized with p-NBD and Gly. The symmetric variable-angle vibration absorption peak of ANH 3 1 at 1471 cm 21 in the p-ABD-Gly-Schiff base indicated that the ANH 2 group occurred in the form of hydrochloride. The stretching vibration peak of aromatic CAN, appearing at 1346 cm 21 in the p-ABD-Gly-Schiff base, was stronger than that in the p-NBD-Gly-Schiff base at 1340 cm 21 .…”

Section: Article Wileyonlinelibrarycom/appmentioning

confidence: 97%

“…Cellulose-based biodegradable polymer materials are expected to become the new abundant and widely used polymer material. 3 Third, cellulose material itself is nontoxic. Therefore, cellulose-based materials will have potential applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and properties of cellulose‐grafted glycine derivatives

Guo

Wang

Sun

et al. 2014

J of Applied Polymer Sci

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Novel Schiff base cellulose derivatives were successfully prepared by a bridge-coupling reaction from dialdehyde cellulose (DAC), which was obtained by the selective oxidation of sodium periodate to cotton fibers, in which the glycine (Gly) was bonded onto the DAC chains by a Schiff base reaction with p-nitrobenzaldehyde as a bridge. The structures of the graft copolymer (DAC-gGly) were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, solid-state NMR, and scanning electronic microscopy. The thermodynamic properties were analyzed by thermogravimetric analysis and differential scanning calorimetry, and the biodegradability was also tested by the microbial degradation and the active sludge method. The results indicate that Gly was connected to DAC by chemical bonding, which changed the thermal stability, and that DAC-g-Gly could be biodegraded significantly.

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Biodegradable and biocompatible polyampholyte microgels derived from chitosan, carboxymethyl cellulose and modified methyl cellulose

Cited by 72 publications

References 28 publications

Modification of chitosan with monomethyl fumaric acid in an ionic liquid solution

Modification of chitosan with monomethyl fumaric acid in an ionic liquid solution

Preparation of carboxymethyl cellulose based microgels for cell encapsulation

Synthesis, characterization and properties of cellulose‐grafted glycine derivatives

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