Biodegradable and Biocompatible Silatrane Polymers

Abstract

In this study, new biodegradable and biocompatible amphiphilic polymers were obtained by modifying the peripheral hydroxyl groups of branched polyethers and polyesters with organosilicon substituents. The structures of the synthesized polymers were confirmed by NMR and GPC. Organosilicon moieties of the polymers were formed by silatranes and trimethylsilyl blocks and displayed hydrophilic and hydrophobic properties, respectively. The effect of the ratio of hydrophilic to hydrophobic organosilicon structures on the surface activity and biological activity of macromolecules was studied, together with the effect on these activities of the macromolecules’ molecular weight and chemical structure. In particular, the critical micelle concentrations were determined, the effect of the structure of the polymers on their wetting with aqueous solutions on glass and parafilm was described, and the aggregation stability of emulsions was studied. Finally, the effect of the polymer structures on their antifungal activity and seed germination stimulation was examined.

3-Aminopropylsilatrane and Its Derivatives: A Variety of Applications

“…The results obtained by Istratov et al indicated the possible creation of biodegradable and biocompatible amphiphilic polymers bearing the silatrane groups. It was found that APS-containing polymers ( 7 ) ( Figure 3 ) positively influence the germination of wheat, oat, and rye seeds (germination percentage, H 2 O—77%, germination percentage, ( 7 )—98%) [ 44 ].…”

Biodegradable Polymer Materials In Medicine

“…It can also prevent biofilm formation or internal tissue damage due to the implant and the subsequent need for secondary surgery [17,18]. In a study [19], new biodegradable and biocompatible amphiphilic polymers were obtained by modifying polyesters with organosilicon substituents. Organosilicon fragments of polymers are formed by silatranes and exhibit hydrophilic and hydrophobic properties, respectively [20].…”

Intrinsic dynamic and static natures of APn--X+--BPn σ(3c–4e) type interactions (APn = BPn = N, P, As and Sb; X = H, F, Cl, Br and I) in bicyclo[3.3.3] and bicyclo[4.4.4] systems and their behaviour, elucidated with QTAIM dual functional analysis

“…[14][15][16][17] Thus, the skeletons of I and II could supply the diverse electronic structures and have unique functionalities, such as superbase, [18][19][20] catalysis [21][22][23] and biological activity. [24][25][26][27] Alder and coworkers synthesized various derivatives of I and II and related species. 9,11,[28][29][30][31] 1,5-Diazabicyclo[3.3.3]undecane (1) 28 and 1,6-diazabicyclo [4.4.4]tetradecane (5) 29 are the typical examples.…”