Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

Turón, Pau; Valle, Luís J. del; Alemán, Carlos; Puiggalı́, Jordi

doi:10.3390/app7010060

Cited by 97 publications

(51 citation statements)

References 171 publications

(206 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Synthesized powders and consolidated samples were characterized by various methods, including X-ray diffraction (XRD), Raman spectroscopy, high-resolution transmission electron microscopy (HR-TEM), and Vickers indentation technique. So far, a lot of research has been done on the applications of HA and graphene materials in the field of theranostics, which confirms the capabilities of these materials in this field [46][47][48][49][50][51]. Given that each phase of the nanocomposite has the potential to be used in biomaterials and theranostics, the synthesized nanocomposite is expected to be usable in biological and theranostic applications.…”

Section: Introductionmentioning

confidence: 72%

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Nosrati

Sarraf-Mamoory

Ahmadi

et al. 2020

JNT

View full text Add to dashboard Cite

In order to investigate the effect of graphene nanoribbons on the final properties of hydroxyapatite-based nanocomposites, a solvothermal method was used at 180 °C and 5 h for the synthesis of graphene nanoribbons–hydroxyapatite nanopowders by employing hydrogen gas injection. Calcium nitrate tetrahydrate and diammonium hydrogenphosphate were used as calcium and phosphate precursors, respectively. To synthesize the powders, a solvent containing diethylene glycol, anhydrous ethanol, dimethylformamide, and water was used. Graphene oxide nanoribbons were synthesized by chemical unzipping of carbon nanotubes under oxidative conditions. The synthesized powders were consolidated by spark plasma sintering methodat 950 °C and a pressure of 50 MPa. The powders and sintered samples were then evaluated using X-ray diffraction, Raman spectroscopy, high-resolution transmission electron microscopy, Vickers microindentation techniques, and biocompatibility assay. The findings of this study showed that the final powders synthesized by the solvothermal method had calcium to phosphate ratio of about 1.67. By adding a small amount of graphene nanoribbon (0.5%W), elastic modulus and hardness of hydroxyapatite increased dramatically. In biological experiments, the difference of hydroxyapatite effect in comparison with the nanocomposite was not significant. The findings of this study showed that graphene nanoribbons have a positive effect on the properties of hydroxyapatite, and these findings would be useful for the medical and theranostic application of this type of nanocomposites.

show abstract

Section: Introductionmentioning

confidence: 72%

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Nosrati

Sarraf-Mamoory

Ahmadi

et al. 2020

JNT

View full text Add to dashboard Cite

show abstract

“…Sokolova et al successfully developed an approach, which involved preparing a double layer coating of calcium phosphate nanoparticles and DNA, showing an increased transfection efficiency compared to a single layer coating [144]. Multi-shell nanoparticles also allow for a more sustained controlled release and longer storage time of 2-3 months [145]. Tenkumo et al fabricated multi-shell nanoparticles, by combining HA with functionalized pDNA, which was subsequently loaded in a collagen scaffold for periodontal tissue repair.…”

Section: Calcium Phosphates Nanoparticles As Non-viral Vectorsmentioning

confidence: 99%

Calcium Phosphate Nanoparticles-Based Systems for RNAi Delivery: Applications in Bone Tissue Regeneration

et al. 2020

View full text Add to dashboard Cite

Bone-related injury and disease constitute a significant global burden both socially and economically. Current treatments have many limitations and thus the development of new approaches for bone-related conditions is imperative. Gene therapy is an emerging approach for effective bone repair and regeneration, with notable interest in the use of RNA interference (RNAi) systems to regulate gene expression in the bone microenvironment. Calcium phosphate nanoparticles represent promising materials for use as non-viral vectors for gene therapy in bone tissue engineering applications due to their many favorable properties, including biocompatibility, osteoinductivity, osteoconductivity, and strong affinity for binding to nucleic acids. However, low transfection rates present a significant barrier to their clinical use. This article reviews the benefits of calcium phosphate nanoparticles for RNAi delivery and highlights the role of surface functionalization in increasing calcium phosphate nanoparticles stability, improving cellular uptake and increasing transfection efficiency. Currently, the underlying mechanistic principles relating to these systems and their interplay during in vivo bone formation is not wholly understood. Furthermore, the optimal microRNA targets for particular bone tissue regeneration applications are still unclear. Therefore, further research is required in order to achieve the optimal calcium phosphate nanoparticles-based systems for RNAi delivery for bone tissue regeneration.

show abstract

“…It is interesting the capacity to modify the surface of electrospun fibers by adding nanoparticles or functional small molecules by means of electrospraying [131,132] (Figure 19 (right image)) [131], which uses low solute concentrations to avoid chain entanglements and favor the formation of droplets. Addition of another polymer or inorganic components such as HAp nanocrystals, bioglass, silica, and calcium carbonate are considered as new potential ways for generating nanofibers with favorable osteoblastic adhesion and cell growth besides the high water affinity and good mechanical performance [124]. Recently Cui et al [133] used the electrospinning technique to provide an artificial periosteum for accelerating the bone regeneration by means of a hybrid hydrogel.…”

Section: Solution Based Fabrication and Electrospinningmentioning

confidence: 99%

Biomimetic Hybrid Systems for Tissue Engineering

2020

Self Cite

View full text Add to dashboard Cite

Tissue engineering approaches appear nowadays highly promising for the regeneration of injured/diseased tissues. Biomimetic scaffolds are continuously been developed to act as structural support for cell growth and proliferation as well as for the delivery of cells able to be differentiated, and also of bioactive molecules like growth factors and even signaling cues. The current research concerns materials employed to develop biological scaffolds with improved features as well as complex preparation techniques. In this work, hybrid systems based on natural polymers are discussed and the efforts focused to provide new polymers able to mimic proteins and DNA are extensively explained. Progress on the scaffold fabrication technique is mentioned, those processes based on solution and melt electrospinning or even on their combination being mainly discussed. Selection of the appropriate hybrid technology becomes vital to get optimal architecture to reasonably accomplish the final applications. Representative examples of the recent possibilities on tissue regeneration are finally given.

show abstract

Biodegradable and Biocompatible Systems Based on Hydroxyapatite Nanoparticles

Cited by 97 publications

References 171 publications

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Synthesis of Graphene Nanoribbons–Hydroxyapatite Nanocomposite Applicable in Biomedicine and Theranostics

Calcium Phosphate Nanoparticles-Based Systems for RNAi Delivery: Applications in Bone Tissue Regeneration

Biomimetic Hybrid Systems for Tissue Engineering

Contact Info

Product

Resources

About