Biodegradable and biocompatible thermosensitive polymer based injectable implant for controlled release of protein

Preparation and Investigation of Sustained Drug Delivery Systems Using an Injectable, Thermosensitive, In Situ Forming Hydrogel Composed of PLGA–PEG–PLGA

“…In the past few years, a number of smart hydrogels have been reported for various biomedical applications, including drug delivery (18)(19)(20)(21), gene delivery (22)(23)(24), cell encapsulation (25,26), and tissue engineering (27). Injectable in situ forming gels are one type of stimuli-sensitive polymers.…”

A one-step modified method to reduce the burst initial release from PLGA microspheres

“…With the rapid growth in the biotechnological field, more and more peptide or protein drugs such as hormones, cytokines, enzymes, and vaccines have been extensively studied for therapeutic availability (Giteau et al, 2008;Tang & Singh, 2009). However, they have many disadvantages, including physical and chemical instabilities relevant with degradation by pH of the gastrointestinal tract or enzyme existed, low oral bioavailability because of their high molecular weights, and frequent injection protocols for their short half-lives in vivo.…”

Basal level insulin delivery: In vitro release, stability, biocompatibility, and in vivo absorption from thermosensitive triblock copolymers

“…In the beginning, there was sign of inflammation reaction due to injury caused by injection. 9 After 3 months of injection of the delivery system, all signs of inflammatory responses disappeared and skin histology of injected site was comparable to control skin samples. The findings of in vivo biocompatibility were in agreement with the in vitro biocompatibility and International Organization for Standardization (ISO) regulations, supporting the biocompatible nature of the thermosensitive copolymers as a delivery system.…”