Biodegradable bone cement compositions based on acrylate and epoxide terminated poly(propylene fumarate) oligomers and calcium salt compositions

Domb, Abraham J.; Manor, Nitza; Elmalak, Omar

doi:10.1016/0142-9612(96)89657-8

Cited by 79 publications

(51 citation statements)

References 8 publications

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“…PPF is an unsaturated linear polyester that can be crosslinked through the double bonds available along its backbone. [8][9][10][11][12] Crosslinking can be carried out through the use of a vinyl monomer, N-vinyl pyrrolidinone, and an initiator, benzoyl peroxide. An orthopedic composite formulation can be formed through the incorporation of sodium chloride as a porogen and ␤-tricalcium phosphate as an osteoconductive agent.…”

Section: Introductionmentioning

confidence: 99%

Crosslinking characteristics of an injectable poly(propylene fumarate)/?-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement

Peter

Kim

Yasko

et al. 1999

J. Biomed. Mater. Res.

193

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We investigated the crosslinking characteristics of an injectable composite paste of poly(propylene fumarate) (PPF), N-vinyl pyrrolidinone (N-VP), benzoyl peroxide (BP), sodium chloride (NaCl), and beta-tricalcium phosphate (beta-TCP). We examined the effects of PPF molecular weight, N-VP/PPF ratio, BP/PPF ratio, and NaCl weight percent on the crosslinking temperature, heat release upon crosslinking, gel point, and the composite compressive strength and modulus. The maximum crosslinking temperature did not vary widely among formulations, with the absolute values falling between 38 degrees and 48 degrees C, which was much lower than that of 94 degrees C for poly(methyl methacrylate) bone cement controls tested under the same conditions. The total heat released upon crosslinking was decreased by an increase in PPF molecular weight and a decrease in N-VP/PPF ratio. The gel point was affected strongly by the PPF molecular weight, with a decrease in PPF molecular weight more rapidly leading to a gel point. An increase in initiator concentration had the same effect to a lesser degree. The time frame for curing was varied from 1-121 min, allowing the composite to be tailored to specific applications. The compressive strength and compressive modulus values increased with decreasing N-VP/PPF, increasing NaCl content, and increasing BP/PPF ratio. For all formulations, the compressive strength values fell between 1 and 12 MPa, and the compressive modulus values fell between 23 and 265 MPa. These data suggest that injectable PPF/beta-TCP pastes can be prepared with handling characteristics appropriate for clinical orthopedic applications and that the mechanical properties of the cured composites are suitable for trabecular bone replacement.

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Section: Introductionmentioning

confidence: 99%

Crosslinking characteristics of an injectable poly(propylene fumarate)/?-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement

Peter

Kim

Yasko

et al. 1999

J. Biomed. Mater. Res.

193

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“…[1][2][3][4][5] They are an important part of the carbon cycle of the Earth, and used in commercial and technical products. [6][7][8][9][10][11] Their detailed structure and mechanisms of formation are currently under intense research. [12][13][14][15][16][17][18][19][20][21] They are commonly structured on a wide range of length scales, 22 which is reflected in that calcite can crystallize around objects and form mesoscopically structured crystals (mesocrystals) in the presence of various additives.…”

Section: Introductionmentioning

confidence: 99%

Kinetic control of particle-mediated calcium carbonate crystallization

2011

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By changing the temperature, pH, stirring rate, or time for calcium carbonate crystallization, complex shapes of aggregated calcium carbonates formed. Such shapes have earlier been ascribed to specific interactions with specialized additives. Without polymeric additives, aggregates of vaterite transformed more rapidly into calcite aggregates under slow than under fast stirring. With an anionic polyelectrolyte added, vaterite was stabilized. Larger polycrystalline aggregates of vaterite formed under rapid than under slow stirring, indicative of a particle mediated growth of aggregates controlled by convective currents. The size of the underlying nanoparticles was temperature dependent,

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“…[1][2][3][4] Of these polymers, poly(propylene fumarate) (PPF) is one of the promising material for tissue engineering applications, especially bone regeneration. PPF is an unsaturated linear polyester that can be crosslinked through carbon double bonds along its backbone 5,6 and degraded by simple hydrolysis of the ester bonds into nontoxic products of propylene glycol, poly(acrylic acid-co-fumaric acid), and fumaric acid. 7 Previous studies have also shown that the addition of ceramic components, such as b-tricalcium phosphate, to PPF enhanced both mechanical strength and osteoconductive properties of the scaffold.…”

Section: Introduction Pmentioning

confidence: 99%

Fabrication and Characterization of Poly(Propylene Fumarate) Scaffolds with Controlled Pore Structures Using 3-Dimensional Printing and Injection Molding

et al. 2006

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Poly(propylene fumarate) (PPF) is an injectable, biodegradable polymer that has been used for fabricating preformed scaffolds in tissue engineering applications because of in situ crosslinking characteristics. Aiming for understanding the effects of pore structure parameters on bone tissue ingrowth, 3-dimensional (3D) PPF scaffolds with controlled pore architecture have been produced in this study from computer-aided design (CAD) models. We have created original scaffold models with 3 pore sizes (300, 600, and 900 lm) and randomly closed 0%, 10%, 20%, or 30% of total pores from the original models in 3 planes. PPF scaffolds were fabricated by a series steps involving 3D printing of support/build constructs, dissolving build materials, injecting PPF, and dissolving support materials. To investigate the effects of controlled pore size and interconnectivity on scaffolds, we compared the porosities between the models and PPF scaffolds fabricated thereby, examined pore morphologies in surface and cross-section using scanning electron microscopy, and measured permeability using the falling head conductivity test. The thermal properties of the resulting scaffolds as well as uncrosslinked PPF were determined by differential scanning calorimetry and thermogravimetric analysis. Average pore sizes and pore shapes of PPF scaffolds with 600-and 900-lm pores were similar to those of CAD models, but they depended on directions in those with 300-lm pores. Porosity and permeability of PPF scaffolds decreased as the number of closed pores in original models increased, particularly when the pore size was 300 lm as the result of low porosity and pore occlusion. These results show that 3D printing and injection molding technique can be applied to crosslinkable polymers to fabricate 3D porous scaffolds with controlled pore structures, porosity, and permeability using their CAD models.

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Biodegradable bone cement compositions based on acrylate and epoxide terminated poly(propylene fumarate) oligomers and calcium salt compositions

Cited by 79 publications

References 8 publications

Crosslinking characteristics of an injectable poly(propylene fumarate)/?-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement

Crosslinking characteristics of an injectable poly(propylene fumarate)/?-tricalcium phosphate paste and mechanical properties of the crosslinked composite for use as a biodegradable bone cement

Kinetic control of particle-mediated calcium carbonate crystallization

Fabrication and Characterization of Poly(Propylene Fumarate) Scaffolds with Controlled Pore Structures Using 3-Dimensional Printing and Injection Molding

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