Biodegradable bone implants in orthopedic applications: a review

Chandra, Girish; Pandey, Ajay

doi:10.1016/j.bbe.2020.02.003

Cited by 134 publications

(66 citation statements)

References 116 publications

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“…A minimum ductility of 4.7% was noted in Mg-2SiO 2 syntactic foam. However, for implants in biomedical applications, a minimum fracture strain of 5% is desired [34]. Therefore, only Mg-0.5SiO 2 and Mg-1.0SiO 2 syntactic foams were further analysed for in-vitro degradation behaviour in different simulated body fluids.…”

Section: Resultsmentioning

confidence: 99%

In-Vitro Degradation of Hollow Silica Reinforced Magnesium Syntactic Foams in Different Simulated Body Fluids for Biomedical Applications

Manakari

Kannan

Parande

et al. 2020

Metals

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This article reports the mechanical and biocorrosion behaviour of hollow silica nanosphere (SiO2) reinforced (0.5–2 vol.%) magnesium (Mg) syntactic foams. Room temperature tensile properties’ characterization suggests that the increased addition of hollow silica nanospheres resulted in a progressive increase in tensile yield strength (TYS) and ultimate tensile strength (UTS) with Mg-2 vol.% SiO2 exhibiting a maximum TYS of 167 MPa and a UTS of 217 MPa. The degradation behaviour of the developed Mg-SiO2 syntactic foams in four different simulated body fluids (SBFs): artificial blood plasma solution (ABPS), phosphate-buffered saline solution (PBS), artificial saliva solution (ASS) and Hanks’ balanced saline solution (HBSS) was investigated by using potentiodynamic polarization studies. Results indicate that corrosion resistance of the Mg-SiO2 syntactic foam decreases with increasing chloride ion concentration of the SBF. Mg-1.0 vol.% SiO2 displayed the best corrosion response and its corrosion susceptibility pertaining to corrosion rate and polarisation curves in different SBF solutions can be ranked in the following order: ABPS > PBS > HBSS > ASS. The surface microstructure demonstrated the presence of a better passivated layer on the syntactic foams compared to pure Mg. The observed increase in corrosion resistance is correlated with intrinsic changes in microstructure due to the presence of hollow silica nanospheres. Further, the effect of corrosive environment on the degradation behaviour of Mg has been elucidated.

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Section: Resultsmentioning

confidence: 99%

In-Vitro Degradation of Hollow Silica Reinforced Magnesium Syntactic Foams in Different Simulated Body Fluids for Biomedical Applications

Manakari

Kannan

Parande

et al. 2020

Metals

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“…(Reproduced with permissions from Ref. [ 99 ]). (f) Healing period for the fixation of autologous bone grafts or bone fracture.…”

Section: Current Research Status On Biomedical Zn-based Biodegradable Metalsmentioning

confidence: 99%

A review on current research status of the surface modification of Zn-based biodegradable metals

Yuan

Xia

et al. 2022

Bioactive Materials

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Recently, zinc and its alloys have been proposed as promising candidates for biodegradable metals (BMs), owning to their preferable corrosion behavior and acceptable biocompatibility in cardiovascular, bone and gastrointestinal environments, together with Mg-based and Fe-based BMs. However, there is the desire for surface treatment for Zn-based BMs to better control their biodegradation behavior. Firstly, the implantation of some Zn-based BMs in cardiovascular environment exhibited intimal activation with mild inflammation. Secondly, for orthopedic applications, the biodegradation rates of Zn-based BMs are relatively slow, resulting in a long-term retention after fulfilling their mission. Meanwhile, excessive Zn 2+ release during degradation will cause in vitro cytotoxicity and in vivo delayed osseointegration. In this review, we firstly summarized the current surface modification methods of Zn-based alloys for the industrial applications. Then we comprehensively summarized the recent progress of biomedical bulk Zn-based BMs as well as the corresponding surface modification strategies. Last but not least, the future perspectives towards the design of surface bio-functionalized coatings on Zn-based BMs for orthopedic and cardiovascular applications were also briefly proposed.

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“…For arriving at an appropriate design of a biodegradable implant plate, LCP design has to be improved with its focus on enhancing the mechanical capability because LCP has already achieved great success with non-biodegradable materials. 1,23 In the LCP, the cross-section is similar to a crescent shape (interconnection of two circles) where the tangential end is thinner and the centreline is thicker. 15,17 This thinner section and its multiple tangential interconnections may be useful in improving the mechanical capability of LCP without affecting the comfort level of orthopaedic patients.…”

Section: Designing Of Laddered Embossed Locking Compression Plate (Lelcp)mentioning

confidence: 99%

“…In the evolution of orthopaedic implants, biodegradable materials have been the well-known and traditional area of research for bone implants because biodegradable materials like Mg-alloy and Zn-alloy have an ability to avoid most of the complications arrived via bone implants made up of non-biodegradable materials. 1,2 Some of these critical complications are re-surgery for removal/replacement of bone implant post healing, a long-term infection that commonly arises with non-biodegradable biomaterials, etc. 3 To avoid these critical issues, a biodegradable implant made up of biodegradable materials can turn out to be a big boon for orthopaedic patients.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of laddered embossed structure in a locking compression plate for biodegradable orthopaedic implants

Chandra

Pandey

2021

J Biomater Appl

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Locking compression plate (LCP) has conventionally been the most extensively employed plate in internal fixation bone implants used in orthopaedic applications. LCP is usually made up of non-biodegradable materials that have a higher mechanical capability. Biodegradable materials, by and large, have less mechanical strength at the point of implantation and lose strength even more after a few months of continuous degradation in the physiological environment. To attain the adequate mechanical capability of a biodegradable bone implant plate, LCP has been modified by adding laddered – type semicircular filleted embossed structure. This improved design may be named as laddered embossed locking compression plate (LELCP). It is likely to provide additional mechanical strength with the most eligible biodegradable material, namely, Mg-alloy, even after continuous degradation that results in diminished thickness. For mechanical validation and comparison of LELCP made up of Mg-alloy, four-point bending test (4PBT) and axial compressive test (ACT) have been performed on LELCP, LCP and continuously degraded LELCP (CD-LELCP) with the aid of finite element method (FEM) for the assembly of bone segments, plate and screw segments. LELCP, when subjected to the above mentioned two tests, has been observed to provide 26% and 10.4% lower equivalent stress, respectively, than LCP without degradation. It is also observed mechanically safe and capable of up to 2 and 6 months of continuous degradation (uniform reduction in thickness) for 4PBT and ACT, respectively. These results have also been found reasonably accurate through real-time surgical simulations by approaching the most optimal mesh. According to these improved mechanical performance parameters, LELCP may be used or considered as a viable biodegradable implant plate option in the future after real life or in vivo validation.

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Biodegradable bone implants in orthopedic applications: a review

Cited by 134 publications

References 116 publications

In-Vitro Degradation of Hollow Silica Reinforced Magnesium Syntactic Foams in Different Simulated Body Fluids for Biomedical Applications

In-Vitro Degradation of Hollow Silica Reinforced Magnesium Syntactic Foams in Different Simulated Body Fluids for Biomedical Applications

A review on current research status of the surface modification of Zn-based biodegradable metals

Effectiveness of laddered embossed structure in a locking compression plate for biodegradable orthopaedic implants

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