Biodegradable colloidal microgels with tunable thermosensitive volume phase transitions for controllable drug delivery

Sung, Baeckkyoung; Kim, Chan-Joong; Kim, Minho

doi:10.1016/j.jcis.2015.02.068

Cited by 47 publications

(29 citation statements)

References 49 publications

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“…We demonstrated that the deswelling behavior of gelatin/p(NIPAM-co-AAm) microgel is induced by the shrinkage of p(NIPAM-co-AAm) polymer chains in response to an increase in temperature; moreover, the deswelling behavior positively correlates with the extent of drug release from the microgel 8 . Taken together, this supports that the shrinkage of p(NIPAM-co-AAm) due to MNPs heating may be the main driving force for the BSA release from gelatin/p(NIPAM-co-AAm)/MNPs microgels.…”

Section: Discussionmentioning

confidence: 93%

“…The incorporation of p(NIPAM-co-AAm) in the gelatin microgel enables it to exhibit a temperature dependent volume change (Figure 2A), in which the increase of temperature of the media from 22 o C to 42 o C resulted in the deswelling of gelatin microgels incorporating p(NIPAM-co-AAm) by ~40% in volume, in contrast to only ~10% volume change for gelatin microgel without p(NIPAM-co-AAm) ( Figure 2B). The extent of deswelling of the gelatin/ p(NIPAM-co-AAm) microgels can be tuned as functions of the crosslinking degree of the gelatin matrix and the concentration of p(NIPAM-coAAm) 8 .…”

Section: Representative Resultsmentioning

confidence: 99%

“…Thus, our results indicate that the release of BSA in response to AMF application was induced by the deswelling of gelatin/p(NIPAM-co-AAm)/MNPs microgel, associated with the shrinkage of p(NIPAM-co-AAm) polymer chains within the microgel (Figure 3). Since the extent of microgel deswelling is proportional to the both extent of temperature increase and concentration of p(NIPAM-co-AAm) 8 , a strategy to increase either amount of MNPs 24 or p(NIPAM-co-AAm) 8 in step 1 in the protocol section may result in increased release of BSA at a given field strength and frequency of AMF application. …”

Section: Representative Resultsmentioning

confidence: 99%

“…The gelatin has been shown to be biocompatible with low immunogenicity and enzymatically degradable 8,27 . The chemical crosslinker, genipin, has been considered to be non-toxic 28 .…”

confidence: 99%

“…The poly(N-isopropylacrylamide) (pNIPAM) or its copolymers have been widely adopted in synthesizing thermo-responsive microgels by grafting pNIPAM with biodegradable/ biocompatible polymers including gelatin, chitosan, alginate acid, or hyaluronic acid 5,6 , in which a phase transition characteristic of pNIPAM at its lower critical solution temperature (LCST) can be used as a trigger of drug release 7 . We recently demonstrated a fabrication of biodegradable, gelatin-based thermo-responsive microgel by incorporating poly(N-isopropylacrylamide-co-acrylamide) [p(NIPAM-co-AAm)] chains as a minor component within three-dimensional gelatin networks 8 . The gelatin/p(NIPAM-co-AAm) microgel exhibited a tunable deswelling to temperature increase, which positively correlated to the release of bovine serum albumin (BSA).…”

Section: Introductionmentioning

confidence: 99%

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Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Sung

Shaffer

Sittek

et al. 2016

JoVE

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Magnetically-responsive nano/micro-engineered biomaterials that enable a tightly controlled, on-demand drug delivery have been developed as new types of smart soft devices for biomedical applications. Although a number of magnetically-responsive drug delivery systems have demonstrated efficacies through either in vitro proof of concept studies or in vivo preclinical applications, their use in clinical settings is still limited by their insufficient biocompatibility or biodegradability. Additionally, many of the existing platforms rely on sophisticated techniques for their fabrications. We recently demonstrated the fabrication of biodegradable, gelatin-based thermo-responsive microgel by physically entrapping poly(N-isopropylacrylamide-co-acrylamide) chains as a minor component within a three-dimensional gelatin network. In this study, we present a facile method to fabricate a biodegradable drug release platform that enables a magneto-thermally triggered drug release. This was achieved by incorporating superparamagnetic iron oxide nanoparticles and thermo-responsive polymers within gelatin-based colloidal microgels, in conjunction with an alternating magnetic field application system. Video LinkThe video component of this article can be found at

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Section: Discussionmentioning

confidence: 93%

Section: Representative Resultsmentioning

confidence: 99%

Section: Representative Resultsmentioning

confidence: 99%

“…The gelatin has been shown to be biocompatible with low immunogenicity and enzymatically degradable 8,27 . The chemical crosslinker, genipin, has been considered to be non-toxic 28 .…”

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Sung

Shaffer

Sittek

et al. 2016

JoVE

Self Cite

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Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments

Caldwell

Aguado

2019

Adv Funct Materials

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Micrometer‐sized hydrogels, termed microgels, are emerging as multifunctional platforms that can recapitulate tissue heterogeneity in engineered cell microenvironments. The microgels can function as either individual cell culture units or can be assembled into larger scaffolds. In this manner, individual microgels can be customized for single or multicell coculture applications, or heterogeneous populations can be used as building blocks to create microporous assembled scaffolds that more closely mimic tissue heterogeneities. The inherent versatility of these materials allows user‐defined control of the microenvironments, from the order of singly encapsulated cells to entire 3D cell scaffolds. These hydrogel scaffolds are promising for moving towards personalized medicine approaches and recapitulating the multifaceted microenvironments that exist in vivo.

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Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

Sung

Kim

Abelmann

2020

Bioengineering & Transla Med

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Soft micro-and nanostructures have been extensively developed for biomedical applications. The main focus has been on multifunctional composite materials that combine the advantages of hydrogels and colloidal particles. Magnetic microgels and nanogels can be realized by hybridizing stimuli-sensitive gels and magnetic nanoparticles. They are of particular interest since they can be controlled in a wide range of biological environments by using magnetic fields. In this review, we elucidate physical principles underlying the design of magnetic microgels and nanogels for biomedical applications. Particularly, this article provides a comprehensive and conceptual overview on the correlative structural design and physical functionality of the magnetic gel systems under the concept of colloidal biodevices. To this end, we begin with an overview of physicochemical mechanisms related to stimuli-responsive hydrogels and transport phenomena and summarize the magnetic properties of inorganic nanoparticles. On the basis of the engineering principles, we categorize and summarize recent advances in magnetic hybrid microgels and nanogels, with emphasis on the biomedical applications of these materials. Potential applications of these hybrid microgels and nanogels in anticancer treatment, protein therapeutics, gene therapy, bioseparation, biocatalysis, and regenerative medicine are highlighted. Finally, current challenges and future opportunities in the design of smart colloidal biodevices are discussed.

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Biodegradable colloidal microgels with tunable thermosensitive volume phase transitions for controllable drug delivery

Cited by 47 publications

References 49 publications

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release

Designing Microgels for Cell Culture and Controlled Assembly of Tissue Microenvironments

Magnetic microgels and nanogels: Physical mechanisms and biomedical applications

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