Biodegradable composites of poly(propylene carbonate) mixed with silicon nitride for osteogenic activity of adipose-derived stem cells and repair of bone defects

IntroductionBone tissue engineering (BTE) provides an effective repair solution by implanting osteoblasts or stem cells into biocompatible and biodegradable scaffolds to promote bone regeneration. In recent years, the rapid development of 3D bioprinting has enabled its extensive application in fabricating BTE scaffolds. Based on three-dimensional computer models and specialized “bio-inks,” this technology offers new pathways for customizing BTE scaffolds. This study reviews the current status and future prospects of scaffold materials for BTE in 3D bioprinting.MethodsThis literature review collected recent studies on BTE and 3D bioprinting, analyzing the advantages and limitations of various scaffold materials for 3D printing, including bioceramics, metals, natural polymers, and synthetic polymers. Key characteristics like biocompatibility, mechanical properties, and degradation rates of these materials were systematically compared.ResultsThe study highlights the diverse performances of materials used in BTE scaffolds. Bioceramics exhibit excellent biocompatibility but suffer from brittleness; metals offer high strength but may induce chronic inflammation; natural polymers are biocompatible yet have poor mechanical properties, while synthetic polymers offer strong tunability but may produce acidic by-products during degradation. Additionally, integrating 3D bioprinting with composite materials could enhance scaffold biocompatibility and mechanical properties, presenting viable solutions to current challenges.DiscussionThis review summarizes recent advances in 3D bioprinting for BTE scaffold applications, exploring the strengths and limitations of various materials and proposing composite material combinations to improve scaffold performance. By optimizing material selection and combinations, 3D bioprinting shows promise for creating customized scaffolds, offering a new technical route for clinical applications of BTE. This research provides a unique perspective and theoretical support for advancing 3D bioprinting technology in bone regeneration, outlining future directions for BTE materials and 3D bioprinting technology development.

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Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair

Gu,

Tang,

et al. 2024

Bioengineering

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Adipose-derived stem cells (ADSCs) have emerged as a promising resource for craniofacial bone regeneration due to their high abundance and easy accessibility, significant osteogenic potential, versatile applications, and potential for personalized medicine, which underscore their importance in this field. This article reviews the current progress of preclinical studies that describe the careful selection of specific ADSC subpopulations, key signaling pathways involved, and usage of various strategies to enhance the osteogenic potential of ADSCs. Additionally, clinical case reports regarding the application of ADSCs in the repair of calvarial defects, cranio-maxillofacial defects, and alveolar bone defects are also discussed.

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Biodegradable composites of poly(propylene carbonate) mixed with silicon nitride for osteogenic activity of adipose-derived stem cells and repair of bone defects

Abstract: Absorbable polymers have attracted a mounting number of attention in the field of bone regeneration in recent years for its degradation. Compared with other degradable polymers, poly propylene carbonate (PPC)...

Cited by 3 publications

References 47 publications

Silicon Nitride Biocomposites

Silicon Nitride Biocomposites

Advances in 3D printing technology for preparing bone tissue engineering scaffolds from biodegradable materials

Optimization and Implication of Adipose-Derived Stem Cells in Craniofacial Bone Regeneration and Repair

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