Biodegradable Core–Multishell Nanocarriers: Influence of Inner Shell Structure on the Encapsulation Behavior of Dexamethasone and Tacrolimus

Abstract

Abstract:We here present the synthesis and characterization of a set of biodegradable core-multishell (CMS) nanocarriers. The CMS nanocarrier structure consists of hyperbranched polyglycerol (hPG) as core material, a hydrophobic (12,15,18,19, and 36 C-atoms) inner and a polyethylene glycol monomethyl ether (mPEG) outer shell that were conjugated by ester bonds only to reduce the toxicity of metabolites. The loading capacities (LC) of the drugs, dexamethasone and tacrolimus, and the aggregate formation, phase transitions, and degradation kinetics were determined. The intermediate inner shell length (C15) system had the best overall performance with good LCs for both drugs as well as a promising degradation and release kinetics, which are of interest for dermal delivery.

Tailor‐Made Core‐Multishell Nanocarriers for the Delivery of Cationic Analgesics to Inflamed Tissue

“…To obtain modified CMS nanocarriers, the syntheses of two previously published CMS nanocarriers (CMS‐E and CMS‐A, see Scheme S1, Supporting Information) were modified . In the previous syntheses, the diacid (2) was reacted first with the polyethylene glycol (PEG, 1) without a catalyst under high temperatures and low pressure to form the double shell (3).…”

“…[40] In brief, an excess of 1,18-octdecandioic acid and methoxy-poly(ethylene glycol) with a MW of 350 were heated up to 180°C under low pressure (0.5·10 -2 mbar) for 2h. [40] In brief, an excess of 1,18-octdecandioic acid and methoxy-poly(ethylene glycol) with a MW of 350 were heated up to 180°C under low pressure (0.5·10 -2 mbar) for 2h.…”

“…[27,40] In the previous syntheses, the diacid (2) was reacted first with the polyethylene glycol (PEG, 1) without a catalyst under high temperatures and low pressure to form the double shell (3). [27,40] In the previous syntheses, the diacid (2) was reacted first with the polyethylene glycol (PEG, 1) without a catalyst under high temperatures and low pressure to form the double shell (3).…”

“…[40] In the case of pCMS, the DF for the anchor molecule (AA) was calculated by first relating the signals assigned to the aromatic protons to the integral of the signals originating from the hPG backbone. In the case of the unfunctionalized CMS nanocarriers, this was done by comparing the aliphatic signal of the inner shell to the combined signal of the PEG/hPGbackbone as previously described.…”

Synthesis, Characterization, Self-Assembly, and Irritation Studies of Polyglyceryl-10 Caprylates

“…Polyglycerin has received many concerns because of its flexible polyether backbone and biocompatibility and can be synthesized using glycerol as raw material by condensation polymerization using acid or base as catalyzer [11,12]. Polyglycerin has numerous hydrophilic hydroxyl groups, which can be modified to prepare different polyglyceryl derivatives for various applications, such as surfactants [13][14][15], food additives [16][17][18], pharmaceuticals [19][20][21], and cosmetics [22,23]. Polyglyceryl fatty acid esters are one of the most investigated polyglyceryl derivatives [24,25], and their chemical and physical properties can be regulated by adjusting the degree of esterification [26].…”