Biodegradable disulfide crosslinked chitosan/stearic acid nanoparticles for dual drug delivery for colorectal cancer

Sood, Ankur; Gupta, Aastha; Bharadwaj, Ravi; Ranganath, Pavana; Silverman, Neal; Agrawal, Garima

doi:10.1016/j.carbpol.2022.119833

Cited by 47 publications

(25 citation statements)

References 33 publications

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“…Thiolation of eudragit S-100 was performed using l -cysteine by following the protocol as mentioned by Sood et al with slight modification. 13 Briefly, EU, EDC, and NHS (10 : 1 : 1 w/w) were mixed and added to l -cysteine in water with an EU : l -cysteine ratio of 2 : 1 (w/w). Afterward, the sample was stirred for 3 h at pH 6.…”

Section: Methodsmentioning

confidence: 99%

“…7–12 However, their successful commercial application is still limited due to the lack of cytotoxic specificity, and the complex biological conditions of the gastrointestinal tract. 13,14…”

Section: Introductionmentioning

confidence: 99%

“…18,24–26 In the case of synthetic polymers, eudragit S-100 (EU) is a hydrophobic copolymer having carboxylic groups. 13 It shows mucoadhesive properties, pH-dependent solubility behaviour, and resistance to the gastric environment. 27–29 Based on the attractive properties of both DE and EU, they can be used in combination to synthesize nanoparticles that are efficient for oral administration for treating colorectal cancer.…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, disulfide crosslinked polymeric nanoparticles are of special interest as they can prevent drug leakage under physiological conditions, and can effectively release the drug under reducing conditions caused by breaking of disulfide bonds. 13,30,31…”

Section: Introductionmentioning

confidence: 99%

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Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy

et al. 2023

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy

et al. 2023

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“…In an investigation performed by Sood et al., [ 204 ] biodegradable disulfide (SS) crosslinked chitosan‐stearic acid NPs (approximately 200 nm) were fabricated for dual drug (hydrophobic curcumin and hydrophilic DOX) delivery for colorectal cancer. The combination of DOX with a natural anticancer agent in a single formulation displayed different mode of anticancer action, developing a system for cancer therapy with improved efficacy.…”

Section: Improved Bioavailability Controlled Release and Anticancer A...mentioning

confidence: 99%

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Falsafi

Wang

Ashaolu

et al. 2022

Adv Funct Materials

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Cancer is the second leading cause of death throughout the world. Nature‐inspired anticancer agents (NAAs) that are a gift of nature to humanity have been extensively utilized in the alleviation/prevention of the disease due to their numerous pharmacological activities. While the oral route is an ideal and common way of drug administration, the application of NAAs through the oral pathway has been extremely limited owing to their inherent features, e.g., poor solubility, gastrointestinal (GI) instability, and low bioavailability. With the development of nano‐driven encapsulation strategies, polymeric vehicles, especially those with natural origins, have demonstrated a potent platform, which can professionally shield versatile NAAs against GI barricades and safely deliver them to the site of action. In this review, the predicament of orally delivering NAAs and the encapsulation strategy solutions based on biopolymer matrices are summarized. Proof‐of‐concept in vitro/in vivo results are also discussed for oral delivery of these agents by various biopolymer vehicles, which can be found so far from the literature. Last but not the least, the challenges and new opportunities in the field are highlighted.

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Functionalized Chitosan Decorated Hafnium Oxide@Gold Core–Shell Nanoparticles for Multimodal Cancer Therapy

Gupta,

Sood,

Bhardwaj

et al. 2023

Advanced Therapeutics

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Herein, we describe the fabrication of chitosan stabilized multifunctional hafnium oxide@gold core‐shell nanoparticles (HAT NPs) (≈12 nm). The developed nanoparticulate system offers multimodal action by providing stimuli responsive anticancer drug delivery along with imparting radiosensitization to cancer cells, thereby protecting surrounding normal tissues from damage. HAT NPs exhibit good capability of loading doxorubicin (DOX), an anticancer drug with ≈ 87% encapsulation efficiency. DOX loaded HAT NPs are able to release ≈ 91% DOX under GSH reducing conditions that is a representative of the cancer cell microenvironment. The cytotoxicity of the developed DOX loaded HAT NPs was tested against breast cancer cells (MDA‐MB‐231), showing higher cytotoxicity as compared to free DOX. Additionally, the ability of HAT NPs to generate ROS activity upon irradiation by gamma radiations (0.5 & 5 Gy) was also analysed in cancer cells to demonstrate the ability of synthesized system as a potent candidate to present radiosensitization. Further, in vivo biodistribution studies was executed to understand the tissue specific retention of HAT NPs for their future utility in targeted cancer treatment applications.This article is protected by copyright. All rights reserved

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Biodegradable disulfide crosslinked chitosan/stearic acid nanoparticles for dual drug delivery for colorectal cancer

Cited by 47 publications

References 33 publications

Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy

Dextran/eudragit S-100 based redox sensitive nanoparticles for colorectal cancer therapy

Biopolymer Nanovehicles for Oral Delivery of Natural Anticancer Agents

Functionalized Chitosan Decorated Hafnium Oxide@Gold Core–Shell Nanoparticles for Multimodal Cancer Therapy

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