Biodegradable gelatin/beta‐tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor‐2 for treatment of recession‐type defects: A split‐mouth study in dogs

Addin, Ammar Shujaa; Akizuki, Tanetaka; Hoshi, Shu; Matsuura, Takanori; Ikawa, Takahiro; Fukuba, Shunsuke; Matsui, Makoto; Tabata, Yasuhiko; Izumi, Yuichi

doi:10.1111/jre.12456

Cited by 15 publications

(21 citation statements)

References 36 publications

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“…Therefore, it can be speculated that a scaffold provides better stability to the blood clot and GF. Consistent with these findings, two recent preclinical studies showed superior outcomes when FGF‐2 was incorporated into the scaffolds compared with FGF‐2 alone . Enhanced new cementum and bone was observed in the site treated with FGF‐2 and a biodegradable sponge, while another group found that a collagen matrix scaffold was able to enhance the amount of root coverage using FGF‐2 at 4 and 16 weeks .…”

Section: Fibroblast Growth Factor‐2supporting

confidence: 53%

“…Fibroblast growth factor‐2 (FGF‐2) is a heparin‐biding cytokine which is able to enhance the angiogenic and osteogenic activity of multiple cellular populations . In addition, FGF‐2 can stimulate the proliferation and migration of mesenchymal cells within the PDL .…”

Section: Fibroblast Growth Factor‐2mentioning

confidence: 99%

“…In addition, FGF‐2 can stimulate the proliferation and migration of mesenchymal cells within the PDL . Given these strong wound healing characteristics, FGF‐2 has been thoroughly explored in periodontal and bone regeneration, alone or in combination with scaffolding matrices . Ishii and coworkers were the first to evaluate the effect of FGF‐2 on root coverage outcomes in vivo .…”

Section: Fibroblast Growth Factor‐2mentioning

confidence: 99%

“…In particular, FGF‐2 + β‐TCP exhibited a greater amount of new bone and cementum formation than FGF‐2 alone, suggesting that the GF benefits when used in combination with a scaffold, which allows cellular and vascular invasion, migration, and growth . When GR occurs, the facial alveolar bone is resorbed resulting in an unfavorable defect architecture for regeneration . Therefore, it can be speculated that a scaffold provides better stability to the blood clot and GF.…”

Section: Fibroblast Growth Factor‐2mentioning

confidence: 99%

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Biologics‐based regenerative technologies for periodontal soft tissue engineering

Tavelli

McGuire

Zucchelli

et al. 2019

Journal of Periodontology

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This manuscript provides a state‐of‐the‐art review on the efficacy of biologics in root coverage procedures, including enamel matrix derivative, platelet‐derived growth factor, platelet concentrates, and fibroblast‐growth factor‐2. The mechanism of action and the rationale for using biologics in periodontal plastic surgery, as well as their anticipated benefits when compared with conventional approaches are discussed. Although the clinical significance is still under investigation, preclinical data and histologic evidence demonstrate that biologic‐based techniques are able to promote periodontal regeneration coupled with the provision of tooth root coverage.

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Section: Fibroblast Growth Factor‐2supporting

confidence: 53%

Section: Fibroblast Growth Factor‐2mentioning

confidence: 99%

Section: Fibroblast Growth Factor‐2mentioning

confidence: 99%

Section: Fibroblast Growth Factor‐2mentioning

confidence: 99%

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Biologics‐based regenerative technologies for periodontal soft tissue engineering

Tavelli

McGuire

Zucchelli

et al. 2019

Journal of Periodontology

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“…In vitro studies showed that acidic gelatin sponge (IEP 5.0) had a high affinity to rhFGF‐2, which is basic in vivo, and formed gelatin complexes ionically . The effect of controlled rhFGF‐2 release can be achieved by gelatin decomposition to enhance hard and soft tissue regeneration in in vivo studies . On the contrary, in vitro studies have reported that basic gelatin sponges (IEP 9.0) rarely have an affinity to rhFGF‐2 and do not exhibit polyion complexation.…”

Section: Discussionmentioning

confidence: 99%

Comparison between different isoelectric points of biodegradable gelatin sponges incorporating β‐tricalcium phosphate and recombinant human fibroblast growth factor‐2 for ridge augmentation: A preclinical study of saddle‐type defects in dogs

Fukuba

Akizuki

Hoshi

et al. 2018

J of Periodontal Research

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Background and Objective It is well known that recombinant human fibroblast growth factor‐2 (rhFGF‐2) signaling plays an important role in tissue repair and regeneration. rhFGF‐2 strongly binds to acidic gelatin via ionic linkages and is gradually released upon gelatin decomposition. On the other hand, the linkage between rhFGF‐2 and basic gelatin is so weak that most rhFGF‐2 is rapidly released from basic gelatin by simple desorption. Gelatin/β‐tricalcium phosphate (β‐TCP) sponges, which comprise 50 wt% gelatin and 50 wt% β‐TCP in a cross‐linked structure, can release rhFGF‐2 gradually owing to their electrical features. In a previous study, we reported that new bone height in the test group using rhFGF‐2 with acidic gelatin/β‐TCP sponges was significantly greater than that in the control group using acidic gelatin/β‐TCP sponges alone in a ridge augmentation model in dogs. However, whether these results depend on controlled release by the gelatin/β‐TCP sponges remains controversial. In this study, we evaluated the effects of controlled release by comparing acidic and basic gelatin/β‐TCP sponges with different isoelectric points (IEP) on ridge augmentation in dogs. Materials and Methods Twelve weeks after extraction of the maxillary second and third incisors of six dogs, critically sized saddle‐type defects (8 mm length × 4 mm depth) were surgically created bilaterally 2 mm from the mesial side of the canine. Acidic gelatin/β‐TCP sponges (IEP 5.0) soaked with 0.3% rhFGF‐2 were applied to the defect in the acidic group, whereas basic gelatin/β‐TCP sponges (IEP 9.0) soaked with 0.3% rhFGF‐2 were applied to the defect in the basic group. Twelve weeks after surgery, biopsy specimens were obtained and subjected to microcomputed tomography (micro‐CT) and histological analyses. Results New bone area detected by micro‐CT analysis was significantly smaller in the basic group than in the acidic group. New bone height calculated by histologic sections was significantly lower in the basic group than in the acidic group. The total tissue height was lower in the basic group than in the acidic group. However, the differences between both sites were not significant. Conclusions These findings suggest that in ridge augmentation of saddle‐type defects, controlled release of rhFGF‐2 induces notably more alveolar bone formation than does short‐term application of rhFGF‐2.

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Development and regeneration of periodontal supporting tissues

Guo

Bai

Wang

et al. 2022

Genesis

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Summary Periodontal tissues, including gingiva, cementum, periodontal ligament, and alveolar bone, play important roles in oral health. Under physiological conditions, periodontal tissues surround and support the teeth, maintaining the stability of the teeth and distributing the chewing forces. However, under pathological conditions, with the actions of various pathogenic factors, the periodontal tissues gradually undergo some irreversible changes, that is, gingival recession, periodontal ligament rupture, periodontal pocket formation, alveolar bone resorption, eventually leading to the loosening and even loss of the teeth. Currently, the regenerations of the periodontal tissues are still challenging. Therefore, it is necessary to study the development of the periodontal tissues, the principles and processes of which can be used to develop new strategies for the regeneration of periodontal tissues. This review summarizes the development of periodontal tissues and current strategies for periodontal healing and regeneration.

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Biodegradable gelatin/beta‐tricalcium phosphate sponges incorporating recombinant human fibroblast growth factor‐2 for treatment of recession‐type defects: A split‐mouth study in dogs

Abstract: Within the limitations of this study, rhFGF-2 in gelatin/β-TCP sponges exhibits an increased potential to support periodontal wound healing/regeneration in canine recession-type defects.

Cited by 15 publications

References 36 publications

Biologics‐based regenerative technologies for periodontal soft tissue engineering

Biologics‐based regenerative technologies for periodontal soft tissue engineering

Comparison between different isoelectric points of biodegradable gelatin sponges incorporating β‐tricalcium phosphate and recombinant human fibroblast growth factor‐2 for ridge augmentation: A preclinical study of saddle‐type defects in dogs

Development and regeneration of periodontal supporting tissues

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