Biodegradable graphene oxide and polyaptamer DNA hybrid hydrogels for implantable drug delivery

Kim, Mi‐Gyeong; Shon, Yuna; Miao, Wenjun; Lee, Jaiwoo; Oh, Yu‐Kyoung

doi:10.1016/j.carbon.2016.04.014

Cited by 34 publications

(28 citation statements)

References 37 publications

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“…In a novel study, injectable hybrid hydrogels were prepared using ssDNA and drug‐specific polyaptamer sequences combined with graphene oxide (GO) nanosheet as a physical cross‐linker . Single‐step RCA was used for a DNA template that was designed to contain 1) kanamycin (Kan)‐aptamer sequence for efficient and specific drug loading and 2) a GO‐binding 12‐mer oligo A sequence ( Figure A).…”

Section: Biomedical Applications Of Dna Hydrogelsmentioning

confidence: 99%

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DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications

Shahbazi

Bauleth‐Ramos

Santos

2018

Advanced Therapeutics

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DNA is a perfect polymeric molecule for interfacing biology with material science to construct hydrogels that represent fascinating properties for a wide variety of biomedical applications. Tunable multifunctionality, convenient programmability, adequate biocompatibility, biodegradability, capability of precise molecular recognition, and high versatility have made DNA an irreplaceable building block for the construction of novel 3D hydrogels. DNA can be used as the only component of a hydrogel, the backbone or a cross-linker that connects the main building blocks to form hybrid hydrogels through chemical reactions or physical entanglement. Responsive constructs of DNA with superior mechanical properties are very commonly reported nowadays, which can undergo macroscopic changes induced by various triggers, including alteration in ionic strength, temperature, and pH. These hydrogels can be prepared by various types of DNA building blocks, such as branched double-stranded DNA, single-stranded DNA, X-shaped DNA, or Y-shaped DNA through intermolecular i-motif structures, DNA hybridization, enzyme ligation, or enzyme polymerization. These hydrogels are envisioned for a variety of applications, such as drug delivery, sensing, tissue engineering, 3D cell culture, and providing template for nanoparticle synthesis.

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Section: Biomedical Applications Of Dna Hydrogelsmentioning

confidence: 99%

“…A3) Antibacterial effect of the PA‐GO hydrogel and Kan/PA‐GO hydrogel on Staphylococcus aureus . Reproduced with permission . Copyright 2016, Elsevier B.V. B1) Schematic procedures of conjugating C‐rich ssDNA to CDs and hydrogel formation at neutral pH for drug encapsulation.…”

Section: Biomedical Applications Of Dna Hydrogelsmentioning

confidence: 99%

DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications

Shahbazi

Bauleth‐Ramos

Santos

2018

Advanced Therapeutics

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“…Additionally, graphene‐containing polymer hydrogel due to its biocompatibility can be used as biosensor, imaging agent, drug delivery carrier, etc . In particular, GO is an effective component in the composite hydrogel for the adjustment of cell behaviors and biological sequences due to its special surface properties.…”

Section: Properties and Applications Of Polymer–graphene Hydrogelsmentioning

confidence: 99%

Recent Progress of Graphene‐Containing Polymer Hydrogels: Preparations, Properties, and Applications

Pan

Liu

Gai

2017

Macro Materials & Eng

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Polymer hydrogels have attracted much attention due to their mechanical, biological, and physicochemical properties. Incorporation of functional material enlarges their applications. Graphene, as a promising additive, has received great attention due to its large specific surface area, ultrahigh conductivity, strong antioxidant, thermal stability, high thermal conductivity, and good mechanical properties. In this brief review, graphene‐containing polymer hydrogels with special properties are summarized including their preparations, properties, and applications. In addition, future perspectives of polymer hydrogels containing graphene are briefly discussed.

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“…[13,14] Attaching DNA oligonucleotides to GO has emerged as a popular method for various analytical, [1,[15][16][17] materials, [18] and biomedical applications. [19][20][21][22] The attached DNA offers molecular recognition functions not only for complementary nucleic acid but also for many metal ions, small molecules, and proteins by using DNA aptamers and DNAzymes. [23][24][25][26][27][28] The ease of synthesis and modification of DNA, its stability, and predictable and programmable structures are highly attractive for sensor design.…”

Section: Introductionmentioning

confidence: 99%

Covalent and Noncovalent Functionalization of Graphene Oxide with DNA for Smart Sensing

Lopez

Liu

2020

Advanced Intelligent Systems

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Interfacing nanomaterials with DNA has resulted in the development of numerous biosensors, optimized for different targets and applications. Of all nanomaterials, graphene oxide (GO) has emerged as a prime sensing platform due to its high specific surface area, good aqueous stability, varied functional groups and desirable surface, and electrical and optical properties. This review starts with an introduction of GO and describes its physical and chemical properties. Then, the general strategies of interfacing DNA and GO to develop sensors are discussed. The trends in GO/DNA biosensor development are organized into classes based on the mode of DNA interaction with GO (physisorbed vs chemisorbed). Due to the intermediate DNA adsorption strength on GO, most of the sensors developed utilize physisorption of DNA to GO. Even within the realm of physisorbed probes, there are multiple sensing methods: direct adsorption, inhibited adsorption, competitive adsorption with the use of blocking agents, and tethered adsorption containing a strongly adsorbing block of DNA. Covalently linked DNA probes are also used to increase the biosensor stability. Each of these sensors has its advantages and disadvantages and the designs are discussed with representative examples in detail.

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Biodegradable graphene oxide and polyaptamer DNA hybrid hydrogels for implantable drug delivery

Cited by 34 publications

References 37 publications

DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications

DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications

Recent Progress of Graphene‐Containing Polymer Hydrogels: Preparations, Properties, and Applications

Covalent and Noncovalent Functionalization of Graphene Oxide with DNA for Smart Sensing

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