Biodegradable Imiquimod-Loaded Mesoporous Organosilica as a Nanocarrier and Adjuvant for Enhanced and Prolonged Immunity against Foot-and-Mouth Disease Virus in Mice
Abstract:Foot-and-mouth
disease (FMD), a serious, fast-spreading, and virulent
disease, has led to huge economic losses to people all over the world.
Vaccines are the most effective way to control FMD. However, the weak
immunogenicity of inactivated FMD virus (FMDV) requires the addition
of adjuvants to enhance the immune effectiveness of the vaccines.
Herein, we formulated and fabricated biodegradable dendritic mesoporous
tetrasulfide-doped organosilica nanoparticles SOMSN with imiquimod
complex (SOMSN-IMQ) and used i… Show more
“…60,62,63 The absolute value of the CD4 + T cell in our work was relatively lower than the results of other literature, which varies from 10% to 40%. [60][61][62][63][64][65][66] However, compared with naked 146S, both CD4 + T and CD 8 + T cells by using 146S@ZIF-8 were statistically higher (Fig. 6c and d).…”
Encapsulating antigens by zeolitic imidazole framework-8 (ZIF-8) exhibits many advantages in vaccine development. However, most viral antigens with complex particulate structures are sensitive to pH or ionic strength, which cannot...
“…60,62,63 The absolute value of the CD4 + T cell in our work was relatively lower than the results of other literature, which varies from 10% to 40%. [60][61][62][63][64][65][66] However, compared with naked 146S, both CD4 + T and CD 8 + T cells by using 146S@ZIF-8 were statistically higher (Fig. 6c and d).…”
Encapsulating antigens by zeolitic imidazole framework-8 (ZIF-8) exhibits many advantages in vaccine development. However, most viral antigens with complex particulate structures are sensitive to pH or ionic strength, which cannot...
“…The cytotoxicity of ZIF-7/8 and ZIF-7/8-ADA NPs on RAW264.7 cells was detected using an CCK-8 assay kit. 41,42 RAW264.7 cells were seeded in 96-well plates in high-glucose Dulbecco's modified Eagle's medium (DMEM), supplemented with 10% FBS with 5% CO 2 at 37 1C and incubated overnight for the cells to adhere. 100 mL of each sample with different concentrations in the range of 0-1000 mg mL À1 was added to the cells.…”
Pseudorabies virus (PRV) is a highly contagious viral disease, and leads to severe financial losses to the breeding industry worldwide. The PRV is mainly controlled using live attenuated and inactivated...
“…Some nanotechnology adjuvants were deployed in the development of vaccines against other diseases, such as MnFe 2 O 4 nanoparticle adjuvanted vaccine against tuberculosis, 538 Ca 3 (PO) 4 , Al(OH) 3 or chitosan nanoparticle adjuvanted vaccine against brucellosis, 539 and MSN adjuvanted vaccine against foot-and-mouth disease. 540 The exemplified nanotechnology adjuvanted vaccines against infectious diseases are summarized in Table 5.…”
Section: Preclinical Development Of Nanotechnology Adjuvantsmentioning
This review provides an introduction of basic principles of adjuvanted human vaccines in clinics and summarizes emerging nanotechnology adjuvants in vaccine development against cancer and infectious diseases.
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