Biodegradable magnesium coronary stents: material, design and fabrication

Demir, Ali Gökhan; Previtali, Barbara; Ge, Qiang; Vedani, Maurizio; Wu, Wei; Migliavacca, Francesco; Petrini, Lorenza; Biffi, Carlo Alberto; Bestetti, Massimiliano

doi:10.1080/0951192x.2013.834475

Cited by 37 publications

(12 citation statements)

References 27 publications

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“…The preliminary analysis on the surface finishing showed the possibility of using the conventional electropolishing method on additively manufactured stents, although the conditions should be further optimized. Heat treatments and chemical/electrochemical finishing operations are part of the conventional manufacturing of cardiovascular stents based on laser microcutting of microtubes [41][42][43]. Hence, the necessity for heat treatment and finishing steps does not necessarily induce longer manufacturing cycles.…”

Section: Discussionmentioning

confidence: 99%

Additive manufacturing of cardiovascular CoCr stents by selective laser melting

2017

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• SLM was used to produce CoCr prototype stents with PW laser emission. • A prototype stent mesh employing design rules for SLM was proposed. • Concentric scanning improved geometrical fidelity compared to hatching. • Prototype stents were similar in surface roughness and microhardness compared to macro SLM components. • The efficacy of electrochemical polishing depended on the correct selection of the SLM scan strategy.

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Section: Discussionmentioning

confidence: 99%

Additive manufacturing of cardiovascular CoCr stents by selective laser melting

2017

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“…Stent thrombosis mostly associated with type DES stents. 34 Suitable stent must have following figures: biocompatible, flexible and capable of expansion. Incompatible implants in human body cause the immune system response, inflammation, trauma and scars.…”

Section: Methodsmentioning

confidence: 99%

A focused review on materials and generations of coronary stents

Shirzadfar

Vahid

Kiafar

et al. 2018

ATROA

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“…Chemical etching with an acidic solution of HNO3 (65% purity) 10 mL, ethanol 90 mL was preferred to remove dross and to clean the kerf. The chemical operation was employed to complete separation of the stent mesh from the scrap pieces as well as to provide strut polishing [24]. The AZ31 stent after chemical etching is reported in Fig.…”

Section: The Stent Productionmentioning

confidence: 99%

Development of biodegradable magnesium alloy stents with coating

Petrini¹,

Wu²,

Gastaldi³

et al. 2014

Frattura Ed Integrità Strutturale

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Biodegradable stents are attracting the attention of many researchers in biomedical and materials research fields since they can absolve their specific function for the expected period of time and then gradually disappear. This feature allows avoiding the risk of long-term complications such as restenosis or mechanical instability of the device when the vessel grows in size in pediatric patients. Up to now biodegradable stents made of polymers or magnesium alloys have been proposed. However, both the solutions have limitations. The polymers have low mechanical properties, which lead to devices that cannot withstand the natural contraction of the blood vessel: the restenosis appears just after the implant, and can be ascribed to the compliance of the stent. The magnesium alloys have much higher mechanical properties, but they dissolve too fast in the human body. In this work we present some results of an ongoing study aiming to the development of biodegradable stents made of a magnesium alloy that is coated with a polymer having a high corrosion resistance. The mechanical action on the blood vessel is given by the magnesium stent for the desired period, being the stent protected against fast corrosion by the coating. The coating will dissolve in a longer term, thus delaying the exposition of the magnesium stent to the corrosive environment. We dealt with the problem exploiting the potentialities of a combined approach of experimental and computational methods (both standard and ad-hoc developed) for designing magnesium alloy, coating and scaffold geometry from different points of views. Our study required the following steps: i) selection of a Mg alloy suitable for stent production, having sufficient strength and elongation capability; ii) computational optimization of the stent geometry to minimize stress and strain after stent deployment, improve scaffolding ability and corrosion resistance; iii) development of a numerical model for studying stent degradation to support the selection of the best geometry; iv) optimization of the alloy microstructure and production of Mg alloy tubes for stent manufacturing; v) set up, in terms of laser cut and surface finishing, of the procedure to manufacture magnesium stents; vi) selection of a coating able to assure enough corrosion resistance and computational evaluation of the coating adhesion. In the paper the multi-disciplinary approach used to go through the steps above is summarized. The obtained results suggest that developed methodology is effective at designing innovative biomedical devices

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Biodegradable magnesium coronary stents: material, design and fabrication

Cited by 37 publications

References 27 publications

Additive manufacturing of cardiovascular CoCr stents by selective laser melting

Additive manufacturing of cardiovascular CoCr stents by selective laser melting

A focused review on materials and generations of coronary stents

Development of biodegradable magnesium alloy stents with coating

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