Biodegradable magnesium/iron batteries with polycaprolactone encapsulation: A microfabricated power source for transient implantable devices

Tsang, Melissa; Armutlulu, Andaç; Martinez, Adam W.; Allen, Sue Ann Bidstrup; Allen, Mark G.

doi:10.1038/micronano.2015.24

Cited by 82 publications

(81 citation statements)

References 34 publications

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“…Copyright 2014, John Wiley and Sons. b) Left: Photograph of the PCL‐encapsulated liquid‐harvesting battery . Middle: Representative photographs of battery degradation during immersion in PBS 1× at 37 °C.…”

Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

“…One year later, Tsang et al proposed a bioresorbable battery based on the employment of electrolytes usually available in the human body, namely, MgCl 2 , NaCl, and PBS, in combination with PCL polymer as separator (Figure b). Magnesium was used as anode and iron as cathode, and the electrodes were separated by and encapsulated in PCL (5 µm thick).…”

Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

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Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

2020

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Over the last decade, scientists have dreamed about the development of a bioresorbable technology that exploits a new class of electrical, optical, and sensing components able to operate in physiological conditions for a prescribed time and then disappear, being made of materials that fully dissolve in vivo with biologically benign byproducts upon external stimulation. The final goal is to engineer these components into transient implantable systems that directly interact with organs, tissues, and biofluids in real‐time, retrieve clinical parameters, and provide therapeutic actions tailored to the disease and patient clinical evolution, and then biodegrade without the need for device‐retrieving surgery that may cause tissue lesion or infection. Here, the major results achieved in bioresorbable technology are critically reviewed, with a bottom‐up approach that starts from a rational analysis of dissolution chemistry and kinetics, and biocompatibility of bioresorbable materials, then moves to in vivo performance and stability of electrical and optical bioresorbable components, and eventually focuses on the integration of such components into bioresorbable systems for clinically relevant applications. Finally, the technology readiness levels (TRLs) achieved for the different bioresorbable devices and systems are assessed, hence the open challenges are analyzed and future directions for advancing the technology are envisaged.

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Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

Section: Bioresorbable Electrical Devicesmentioning

confidence: 99%

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Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

2020

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Section: Energy Storage Systemsmentioning

confidence: 99%

Materials Strategies and Device Architectures of Emerging Power Supply Devices for Implantable Bioelectronics

Huang

Wang

et al. 2019

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107

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Implantable bioelectronics represent an emerging technology that can be integrated into the human body for diagnostic and therapeutic functions. Power supply devices are an essential component of bioelectronics to ensure their robust performance. However, conventional power sources are usually bulky, rigid, and potentially contain hazardous constituent materials. The fact that biological organisms are soft, curvilinear, and have limited accommodation space poses new challenges for power supply systems to minimize the interface mismatch and still offer sufficient power to meet clinical‐grade applications. Here, recent advances in state‐of‐the‐art nonconventional power options for implantable electronics, specifically, miniaturized, flexible, or biodegradable power systems are reviewed. Material strategies and architectural design of a broad array of power devices are discussed, including energy storage systems (batteries and supercapacitors), power devices which harvest sources from the human body (biofuel cells, devices utilizing biopotentials, piezoelectric harvesters, triboelectric devices, and thermoelectric devices), and energy transfer devices which utilize sources in the surrounding environment (ultrasonic energy harvesters, inductive coupling/radiofrequency energy harvesters, and photovoltaic devices). Finally, future challenges and perspectives are given.

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“…9 Recently, Nadeau et al demonstrated an ingestible battery based on Zn and Cu that is activated by gastric fluid. 10 Aside from the implantable applications, a biodegradable super capacitor was recently reported as an environmentally friendly energy storage solution.…”

mentioning

confidence: 99%

Evaluation of Redox Chemistries for Single-Use Biodegradable Capillary Flow Batteries

Ibrahim

Alday

Sabaté

et al. 2017

J. Electrochem. Soc.

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The rate of battery waste generation is rising dramatically worldwide due to increased use and consumption of electronic devices. A new class of portable and biodegradable capillary flow batteries was recently introduced as a solution for single-use disposable applications. The concept utilizes stored organic redox species and supporting electrolytes inside a dormant capillary flow cell which is activated by the dropwise addition of aqueous liquid. Herein, various organic redox species are systematically evaluated for prospective use in disposable capillary flow cells with regards to their electrochemical characteristics, solubility, storability and biodegradability. Qualitative ex-situ techniques are first applied to assess half-cell solubility, redox potential and kinetics, followed by quantitative in-situ measurements of discharge performance of selected redox chemistries in a microfluidic cell with flow-through porous electrodes. Para-benzoquinone in oxalic acid and either hydroquinone sulfonic acid or ascorbic acid in potassium hydroxide are identified for the positive and negative half-cells, respectively, yielding a maximum discharge power density of 50 mW/cm 2 . A prototype capillary flow battery using the same redox chemistries demonstrates robust cell voltages above 1.0 V and maximum discharge power of 1.9 mW. These results show that practical primary battery performance can be achieved with biodegradable chemistries in a disposable device. The market demand for small-size single-use electronic devices such as portable sensors and diagnostic devices has been rising drastically in recent years. The power needs of such devices have so far been met by Li-ion batteries and other primary battery technologies, resulting in a consequent rise in their consumption. These batteries often contain heavy metals and strong electrolytes which make them one of the most hazardous components of electronic waste.1 In addition, the majority of the primary Li batteries used globally are not recycled nor properly disposed of, thus ending up in landfills without regulations.2 In applications that do not require long discharge times and have modest capacity requirements such as medical devices, these batteries are not even fully discharged before being disposed of. This requires further resources for re-extracting the materials if not recovered, which is not sustainable and raises concerns about the abundance of these resources. The end-of-life fate of these batteries and their life cycle assessment therefore only justifies the use in rechargeable applications beyond hundreds of cycles.3,4 These issues trigger a worrying concern about associated future environmental hazards from the battery waste generation and urgently call for novel alternatives, tightened environmental policies and switching the linear consumption habit of "take-make-dispose" for these primary batteries into a circular economy model. This approach utilizes novel concepts such as green electronics and cradle-to-cradle design to eliminate waste from the conc...

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Biodegradable magnesium/iron batteries with polycaprolactone encapsulation: A microfabricated power source for transient implantable devices

Cited by 82 publications

References 34 publications

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

Bioresorbable Materials on the Rise: From Electronic Components and Physical Sensors to In Vivo Monitoring Systems

Materials Strategies and Device Architectures of Emerging Power Supply Devices for Implantable Bioelectronics

Evaluation of Redox Chemistries for Single-Use Biodegradable Capillary Flow Batteries

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