Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari, Mohammad; Hang, Ruiqiang; Chang, Wang; Yu, Zhentao; Li, Zhi Yong; Xiao, Yin

doi:10.3390/met8040212

Cited by 42 publications

(22 citation statements)

References 165 publications

(258 reference statements)

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“…First, when the metallic material comes into contact with the solution, a complex oxide layer (FeO/MnO/SiO/MgO/CaO) grows and, at least at the beginning, protects the metallic material. The mechanisms of corrosion are presented in different articles [24][25][26][27] and the experimental results, Figures 3 and 4, are in total agreement. Second, the oxides interact with the solution and form hydroxides and grow a new layer with a lower stability (Figure 8b) that continuously interacts with chloride ions to form soluble compounds that pass to the SBF solution, as confirmed by Table 1 and Figure 1 experimental results.…”

Section: Discussionsupporting

confidence: 55%

Electrochemical Behavior of Biodegradable FeMnSi–MgCa Alloy

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Istrate

et al. 2018

Metals

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Nowadays, alongside metallic biomaterials, there is increasing interest in using degradable metals in an appreciable number of medical applications. There are new kinds of metallic biomaterials for medical applications and many new findings have been reported over the past few years. Iron-based materials are a solution for biodegradable applications based on their mechanical and chemical properties. In order to control the corrosion rate of the Fe10Mn6Si alloy, we proposed the use of two additional elements, Ca and Mg, as corrosion promoters. The new material was obtained in an air-controlled atmosphere furnace after five melting operations. The material was in vitro analyzed from a corrosion resistance point of view. The experiments were realized by immersion (7, 14, and 30 days) in simulated body fluid (SBF) solution at 37 • C and a constant pH, and by electrochemical tests (electrochemical impedance spectroscopy (EIS), linear polarization (LP), cyclic polarization (CP)). Material surfaces before and after corrosion tests were analyzed through scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD) techniques. A discussion on the degradation rate of the material was realized from a comparison of the results. The results presented good composition homogeneity after the re-melting stages, with low percentages of Ca and Mg in the material, but with an adequate spread in the alloy.

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Section: Discussionsupporting

confidence: 55%

Electrochemical Behavior of Biodegradable FeMnSi–MgCa Alloy

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Săndulache

Istrate

et al. 2018

Metals

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“…DAPI (4 ,6-diamidino-2-phenylindole, 1/1000, Sigma-Aldrich) was added to the secondary antibody for nuclear staining. For whole tissue studies, the techniques were modified from published reports [41,42]. Skin samples with metal ribbon material were rinsed after fixation (PBS) and dehydrated in a series of increasing concentrations of methanol to 100% methanol (15-30 min incubations).…”

Section: In-vivo Studymentioning

confidence: 99%

“…The other two stents showed either a higher radial force 0.25 N/mm (U-design) or a very high percentage strain and low radial force of 0.07N/mm (Omega-design). Zn stents fall in a similar For whole tissue studies, the techniques were modified from published reports [41,42]. Skin samples with metal ribbon material were rinsed after fixation (PBS) and dehydrated in a series of increasing concentrations of methanol to 100% methanol (15-30 min incubations).…”

Section: Mechanical Testingmentioning

confidence: 99%

In Vitro and In Vivo Testing of Zinc as a Biodegradable Material for Stents Fabricated by Photo-Chemical Etching

et al. 2019

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There is an increasing interest in biodegradable metal implants made from magnesium (Mg), iron (Fe), zinc (Zn) and their alloys because they are well tolerated in vivo and have mechanical properties that approach those of non-degradable metals. In particular, Zn and its alloys show the potential to be the next generation of biodegradable materials for medical implants. However, Zn has not been as well-studied as Mg, especially for stent applications. Manufacturing stents by laser cutting has become an industry standard. Nevertheless, the use of this approach with Zn faces some challenges, such as generating thermal stress, dross sticking on the device, surface oxidation, and the need for expensive thin-walled Zn tubing and post-treatment. All of these challenges motivated us to employ photo-chemical etching for fabricating different designs of Zn (99.95% pure) stents. The stents were constructed with different strut patterns, made by photo-chemical etching, and mechanically tested to evaluate radial forces. Stents with rhombus design patterns showed a promising 0.167N/mm radial force, which was comparable to Mg-based stents. In vitro studies were conducted with uncoated Zn stents as control and Parylene C-coated Zn stents to determine corrosion rates. The Parylene C coating reduced the corrosion rate by 50% compared to uncoated stents. In vivo studies were carried out by implanting photo-chemically etched, uncoated Zn stent segments subcutaneously in a C57BL/6 mice model. Histological analyses provided favorable data about the surrounding tissue status, as well as nerve and blood vessel responses near the implant, providing insights into the in vivo degradation of the metal struts. All of these experiments confirmed that Zn has the potential for use in biodegradable stent applications.

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“…High Zn compatibility to magnetic resonance imaging is an additional advantage of this promising candidate for biodegradable stents as compared to iron-and magnesium-based stent materials. The efforts in the development of new Zn-based stent materials are only at the beginning and an increasing number of scientific groups is working on this topic [133,142,[145][146][147][148][149][150][151]. The results of the different studies related to the properties of Zn stents are summarized in Table 2.…”

Section: Zn Stentsmentioning

confidence: 99%

Recent Advances in Manufacturing Innovative Stents

et al. 2020

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Cardiovascular diseases are the most distributed cause of death worldwide. Stenting of arteries as a percutaneous transluminal angioplasty procedure became a promising minimally invasive therapy based on re-opening narrowed arteries by stent insertion. In order to improve and optimize this method, many research groups are focusing on designing new or improving existent stents. Since the beginning of the stent development in 1986, starting with bare-metal stents (BMS), these devices have been continuously enhanced by applying new materials, developing stent coatings based on inorganic and organic compounds including drugs, nanoparticles or biological components such as genes and cells, as well as adapting stent designs with different fabrication technologies. Drug eluting stents (DES) have been developed to overcome the main shortcomings of BMS or coated stents. Coatings are mainly applied to control biocompatibility, degradation rate, protein adsorption, and allow adequate endothelialization in order to ensure better clinical outcome of BMS, reducing restenosis and thrombosis. As coating materials (i) organic polymers: polyurethanes, poly(ε-caprolactone), styrene-b-isobutylene-b-styrene, polyhydroxybutyrates, poly(lactide-co-glycolide), and phosphoryl choline; (ii) biological components: vascular endothelial growth factor (VEGF) and anti-CD34 antibody and (iii) inorganic coatings: noble metals, wide class of oxides, nitrides, silicide and carbide, hydroxyapatite, diamond-like carbon, and others are used. DES were developed to reduce the tissue hyperplasia and in-stent restenosis utilizing antiproliferative substances like paclitaxel, limus (siro-, zotaro-, evero-, bio-, amphi-, tacro-limus), ABT-578, tyrphostin AGL-2043, genes, etc. The innovative solutions aim at overcoming the main limitations of the stent technology, such as in-stent restenosis and stent thrombosis, while maintaining the prime requirements on biocompatibility, biodegradability, and mechanical behavior. This paper provides an overview of the existing stent types, their functionality, materials, and manufacturing conditions demonstrating the still huge potential for the development of promising stent solutions.

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Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Cited by 42 publications

References 165 publications

Electrochemical Behavior of Biodegradable FeMnSi–MgCa Alloy

Electrochemical Behavior of Biodegradable FeMnSi–MgCa Alloy

In Vitro and In Vivo Testing of Zinc as a Biodegradable Material for Stents Fabricated by Photo-Chemical Etching

Recent Advances in Manufacturing Innovative Stents

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