Biodegradable microspheres of poly(3‐hydroxybutyrate)/poly(ε‐caprolactone) loaded with malathion pesticide: Preparation, characterization, and <i>in vitro</i> controlled release testing

Suave, Jaqueline; Dall’Agnol, Evana Cássia; Pezzin, Ana Paula Testa; Meier, Márcia Margarete; Silva, D. A. K.

doi:10.1002/app.32082

Cited by 50 publications

(42 citation statements)

References 44 publications

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“…The genotoxicity of atrazine-loaded P(3HB/3HV) microspheres was decreased in relation to atrazine alone [21]. Microspheres of pure polymers of PHB and poly(e-caprolactone) loaded with malathion pesticide were fabricated and examined in another work [23]. The effect of the pesticide on the morphology and particle size of the biodegradable microspheres was examined.…”

Section: Discussionmentioning

confidence: 99%

“…In initial experiments using the pesticides HCH and lindane, we demonstrated the potential of using degradable polyhydroxyalkanoates as a matrix for embedding these compounds to enable their targeted and controlled release to the environment [20]. Recently, the ability to prepare PHA microparticles loaded with herbicide or pesticide and viable biodegradable release systems for agrochemical purposes has been demonstrated [21][22][23]. These previous works mainly examine the compound release kinetics in vitro.…”

Section: Introductionmentioning

confidence: 99%

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Degradable Polyhydroxyalkanoates as Herbicide Carriers

et al. 2012

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The biodegradable polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) has been used to design experimental sustained-release formulations of the herbicide Zellek Super in the form of films and microgranules. The kinetics of polymer degradation and the dynamics of herbicide release show that the rate and extent of herbicide release from the polymer matrix into the soil depends on the geometry of the carrier and the proportion of the pesticide loaded into it (polymer/pesticide mass ratio). Experiments with the creeping bentgrass (Agrostis stolonifera L.) show that the formulations of the herbicide Zellek Super constructed as microgranules and films can be successfully used to suppress the growth of grasses. This study is the first to demonstrate that biodegradable polyhydroxyalkanoates can be used effectively to construct environmentally friendly sustained-release PHA-herbicide systems that can be placed into the soil together with seeds.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Degradable Polyhydroxyalkanoates as Herbicide Carriers

et al. 2012

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“…As microesferas de P(3HB)/PCL foram preparadas pelo método de emulsificação-evaporação do solvente, conforme descrito anteriormente [37] . Os experimentos foram feitos com diferentes composições poliméricas P(3HB)/PCL: 100/0, 97/03, 95/05, 90/10, 80/20, 70/30, e 0/100 (m/m).…”

Section: Síntese Das Microesferasunclassified

Microencapsulação do pesticida cipermetrina em blendas de P(3HB/PCL): caracterização e ensaio de liberação in vitro

et al. 2016

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ResumoA aplicação de polímeros biodegradáveis para encapsular pesticidas é uma estratégia que permite, a partir de diferentes proporções entre os polímeros, modificar o perfil de liberação do agente. Este trabalho avaliou a liberação controlada do pesticida cipermetrina encapsulado em microesferas de blendas de P(3HB)/PCL (100/0, 0/100, 97/03, 95/05, 90/10, 80/20 e 70/30) obtidas pelo método de emulsificação-evaporação do solvente. As imagens de microscopia eletrônica de varredura revelam a forte influência da PCL na porosidade das microesferas. As análises de infravermelho mostraram a presença do pesticida em todas as composições de polímeros avaliadas. O ensaio de liberação de cipermetrina sugere que, no intervalo de 4 horas, o teor de cipermetrina liberada é dependente da composição das blendas utilizadas. As microesferas de PHB e blendas com menores teores de PCL, 97/03 e 95/05 liberaram 75% a 85% enquanto a composição 70/30 liberou 100% de cipermetrina. Palavras-chave: polímeros biodegradáveis, blendas, microencapsulação. AbstractThis work evaluated the controlled release of cypermethrin pesticide loaded in microspheres of P(3HB)/PCL blends obtained by emulsion-evaporation method. SEM analysis revealed a strong influence of PCL on the porosity of the microspheres. The infrared spectra showed the presence of pesticide in all polymer compositon evaluated. DSC curves showed that with higher content of PCL, decreased the crystallinity degree of polymers, resulting in a faster release of the pesticide. The release assay of cypermethrin suggests that within an interval of four hours the amount of pesticide released varies depending on the composition of the blends.

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“…As aplicações do P(3HB) são diversas, estando presentes nas embalagens biodegradáveis, em embalagens de produtos agrícolas no transporte de pequenas mudas (VOLGELSANGER et al, 2002), na engenharia tecidual, em função de sua biocompatibilidade, para fabricação de próteses e outros componentes médicos devido ao fato de não gerar em sua degradação substâncias tóxicas (BYROM, 1987;WILLIAMS et al, 1999), em escovas de dente (MEDEIROS et al, 2005), na formulação de cápsulas para liberação controlada de fármacos e pesticidas (SUAVE et al, 2010).…”

Section: Polihidroxialcanoatos -Phasunclassified