Biodegradable nanocarrier of gemcitabine and tocopherol succinate synergistically ameliorates anti-proliferative response in MIA PaCa-2 cells

Behera, Chittaranjan; Kaur Sandha, Kamalpreet; Banjare, Nagma; Kumar Shukla, Monu; Mudassir Ali, Syed; Singh, Manisha; Gupta, Prem N.

doi:10.1016/j.ijpharm.2023.123599

International Journal of Pharmaceutics

2024

DOI: 10.1016/j.ijpharm.2023.123599

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Biodegradable nanocarrier of gemcitabine and tocopherol succinate synergistically ameliorates anti-proliferative response in MIA PaCa-2 cells

Chittaranjan Behera,

Kamalpreet Kaur Sandha,

Nagma Banjare

et al.

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Development and characterization of Myrica esculenta plant extract-based albumin nanoparticles for anticancer activity

Shukla,

Kaushik,

Tiwari

et al. 2024

Industrial Crops and Products

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Development and characterization of Myrica esculenta plant extract-based albumin nanoparticles for anticancer activity

Shukla,

Kaushik,

Tiwari

et al. 2024

Industrial Crops and Products

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Individual and Dual Cytotoxicity of the Combination of Passiflora Caerulea Leaf Extract and Titanium Oxide Nanoparticles against A549, U937, and Hela Cells

Sindhura,

Bobby,

Srikanth

et al. 2025

CBC

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Background: The study addresses the underexplored realm of cytotoxicity evaluation involving binary mixtures of Passiflora caerulea leaf extracts and Titanium nanoparticles (TiO2NPs). The focus lies on understanding the combined effects of these components on cancer cells (A549, U937, and HeLa). Methods: In vitro cytotoxicity assessments were employed to evaluate the toxicity of P. caerulea leaf extracts, TiO2NPs, and their combination. The study utilized MTT, NRU, and LDH assays to measure cellular viability. Additionally, reactive oxygen species (ROS) and glutathione levels were assessed alongside the aforementioned assays. Results: The toxicity percentage exhibited dose-dependent behavior for P. caerulea leaf extracts, TiO2NPs, and their combination. Interestingly, when P. caerulea leaf extract and TiO2NPs were combined, the reduction in cell viability was noticeably more than when the exposures were made separately. Moreover, the production of ROS was higher in the combined toxicity scenario, and a more pronounced decrease in glutathione levels was observed compared to individual exposures. Conclusion: The findings suggest that the combined effects of P. caerulea leaf extract and TiO2NPs induce greater cytotoxicity compared to their impacts. This underscores the potential for synergistic cytotoxicity in combined exposure scenarios, warranting further exploration of combined effects in future studies.

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Biodegradable nanocarrier of gemcitabine and tocopherol succinate synergistically ameliorates anti-proliferative response in MIA PaCa-2 cells

Cited by 2 publications

References 50 publications

Development and characterization of Myrica esculenta plant extract-based albumin nanoparticles for anticancer activity

Development and characterization of Myrica esculenta plant extract-based albumin nanoparticles for anticancer activity

Individual and Dual Cytotoxicity of the Combination of Passiflora Caerulea Leaf Extract and Titanium Oxide Nanoparticles against A549, U937, and Hela Cells

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