Biodegradable nanocarriers based on chitosan-modified mesoporous silica nanoparticles for delivery of methotrexate for application in breast cancer treatment

Shakeran, Zahra; Keyhanfar, Mehrnaz; Varshosaz, Jaleh; Sutherland, Duncan S.

doi:10.1016/j.msec.2020.111526

Cited by 103 publications

(48 citation statements)

References 86 publications

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“…The calculation showed that the drug loading efficiency was 19.22% (DOX) and 7.33% (ICG). Compared to traditional MSNs, 48 the total drug loading was higher, which benefited from the hollow structure of HMSNs. The drug release behaviors of ID@HMSNs-SNH were examined at different pH values and GSH concentrations (Fig.…”

Section: Resultsmentioning

confidence: 99%

Targeted pH/redox dual-responsive nanoparticles for cancer chemotherapy combined with photodynamic/photothermal therapy

Chang

Wang

et al. 2022

New J. Chem.

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Section: Resultsmentioning

confidence: 99%

Targeted pH/redox dual-responsive nanoparticles for cancer chemotherapy combined with photodynamic/photothermal therapy

Chang

Wang

et al. 2022

New J. Chem.

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“…The concentration at a given time (t) was obtained by the calibration curve of MTX. The standard calibration curve of methotrexate in PBS (1,2,3,4,6,8,10,15,20,25,30 µg/)mL was obtained and release was determined by Equation (5) [45,72].…”

Section: In-vitro Drug Releasementioning

confidence: 99%

“…Wang et al, (2021) prepared lactobionic modified thymine and CS comprised nanocarriers for MTX [24]. A biodegradable nanocarrier based on CS and silica was synthesized by Shakeran et al, for the treatment of breast cancer [25]. Bhattacharya formulated polymeric lipid hybrid NPs for glioma treatment by MTX [26].…”

Section: Introductionmentioning

confidence: 99%

pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation

Noreen

Hasan

Ghumman

et al. 2022

IJMS

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The rapid progression in biomaterial nanotechnology apprehends the potential of non-toxic and potent polysaccharide delivery modules to overcome oral chemotherapeutic challenges. The present study is aimed to design, fabricate and characterize polysaccharide nanoparticles for methotrexate (MTX) delivery. The nanoparticles (NPs) were prepared by Abelmoschus esculentus mucilage (AEM) and chitosan (CS) by the modified coacervation method, followed by ultra-sonification. The NPs showed much better pharmaceutical properties with a spherical shape and smooth surface of 213.4–254.2 nm with PDI ranging between 0.279–0.485 size with entrapment efficiency varying from 42.08 ± 1.2 to 72.23 ± 2.0. The results revealed NPs to possess positive zeta potential and a low polydispersity index (PDI). The in-vitro drug release showed a sustained release of the drug up to 32 h with pH-dependence. Blank AEM -CS NPs showed no in-vivo toxicity for a time duration of 14 days, accompanied by high cytotoxic effects of optimized MTX loaded NPs against MCF-7 and MD-MBA231 cells by MTT assay. In conclusion, the findings advocated the therapeutic potential of AEM/CS NPs as an efficacious tool, offering a new perspective for pH-responsive routing of anticancer drugs with tumor cells as a target.

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“…Generally speaking, the driving force of nanocarrier in tumor tissues was based on enhanced permeability and retention (EPR) mechanism ( 81 , 82 ). Utilizing the passive mechanisms of EPR still remains a critical design parameter of nanocarrier delivery to tumors, however, inefficient drug release and uptake by the endosomes can limit their therapeutic efficacy ( 83 ).…”

Section: Application Of Nanocarrier In the Delivery Of Pharmaceuticalsmentioning

confidence: 99%

A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

et al. 2021

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Recently, owing to well-controlled release, enhanced distribution and increased permeability, nanocarriers used for alternative drug and food-delivery strategies have received increasingly attentions. Nanocarriers have attracted a large amount of interest as potential carriers of various bioactive molecules for multiple applications. Drug and food-based delivery via polymeric-based nanocarriers and lipid-based nanocarriers has been widely investigated. Nanocarriers, especially liposomes, are more and more widely used in the area of novel nano-pharmaceutical or food-based design. Herein, we aimed to discuss the recent advancement of different surface-engineered nanocarriers type, along with cutting-edge applications for food and nanomedicine and highlight the alternative of phytochemical as nanocarrier. Additionally, safety concern of nanocarriers was also highlighted.

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Biodegradable nanocarriers based on chitosan-modified mesoporous silica nanoparticles for delivery of methotrexate for application in breast cancer treatment

Cited by 103 publications

References 86 publications

Targeted pH/redox dual-responsive nanoparticles for cancer chemotherapy combined with photodynamic/photothermal therapy

Targeted pH/redox dual-responsive nanoparticles for cancer chemotherapy combined with photodynamic/photothermal therapy

pH Responsive Abelmoschus esculentus Mucilage and Administration of Methotrexate: In-Vitro Antitumor and In-Vivo Toxicity Evaluation

A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems

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