Biodegradable nanoparticles made from polylactide-grafted dextran copolymers

Interfacial click chemistry for improving both dextran shell density and stability of biocompatible nanocapsules

“…NCs, thanks to their specific morphology, 8 present many advantages over NSs such as: (i) versatility of encapsulated compounds (either 9 hydrophilic or hydrophobic) depending on their liquid core polarity [6], (ii) high loading 10 capacity related to the liquid core volume and the active substance solubility [4,7], (iii) 11 possibility to modulate the substance release by adjusting nature and thickness of the polymer 12 shell, but also by tuning polarity and volume of the liquid core [8,9], (iv) reduced polymer 13 content [4], (v) protection of encapsulated substance when loaded within the central cavity [4, 14 7]. NCs such as other polymeric nanoparticles (NPs) may also be covered by a hydrophilic 15 shell (for examples polyethylene glycol [10,11] or a neutral, biodegradable and 16 biocompatible polysaccharide such as dextran [12][13][14]) to ensure their colloidal stability or 17 stealthiness in case of drug delivery systems. 18 Our team has previously reported successful preparation of dextran-covered PLA NSs by 19 nanoprecipitation [12,13] or emulsion/evaporation techniques [13][14][15].…”

“…NCs such as other polymeric nanoparticles (NPs) may also be covered by a hydrophilic 15 shell (for examples polyethylene glycol [10,11] or a neutral, biodegradable and 16 biocompatible polysaccharide such as dextran [12][13][14]) to ensure their colloidal stability or 17 stealthiness in case of drug delivery systems. 18 Our team has previously reported successful preparation of dextran-covered PLA NSs by 19 nanoprecipitation [12,13] or emulsion/evaporation techniques [13][14][15]. Taking into account 20 NCs numerous advantages, our interest was focused on preparation of NCs stabilized by a 21 hydrophilic coverage of dextran.…”

Efficient Delivery of Antitumor Drug to the Nuclei of Tumor Cells by Amphiphilic Biodegradable Poly(L‐Aspartic Acid‐co‐Lactic Acid)/DPPE Co‐Polymer Nanoparticles

“…Due to the obvious advantages, such as prolonged retention in blood circulation, improved stability, reduced nonspecific uptake by the reticuloendothelial system, enhanced accumulation in tumor tissue, and targeted delivery, the polymeric NPs self‐assembled from amphiphilic co‐polymers have been extensively investigated as drug delivery systems 1–6. Notable examples of chemotherapeutic NPs include Doxil (100 nm liposomal formulation of doxorubicin) and Abraxane (130 nm paclitaxel‐bound protein particle), are clinical chemotherapy drug.…”

Nanoparticles from renewable polymers

“…In fact, diclofenac could be almost completely retained in PDLA for 8 months (Guterres et al, 1995). Control of the degradation properties was achieved by using graft copolymers, consisting of a polysaccharide backbone and grafted PLA (Nouvel et al, 2009) or PLGA chains. Polysaccharide specific enzymes degraded the backbone leading to decomposition of the whole nanostructure, leading to faster release than in the absence of the enzyme (Jeong et al, 2006a,b).…”