Biodegradable Pericardial Implants for Bladder Augmentation: A 2.5-Year Study in Dogs

Kambic, Helen; Kay, Robert; Chen, J.-F.; Matsushita, Michiaki; Harasaki, Hiroaki; Zilber, Sofia

doi:10.1016/s0022-5347(17)36649-1

Cited by 80 publications

(34 citation statements)

References 18 publications

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“…The bovine pericardium used for bladder substitution is biodegradable and allows com- plete epithelization within 4 to 8 weeks (29)(30)(31)(32). The question of bladder muscle regeneration is controversial.…”

Section: Discussionmentioning

confidence: 99%

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Urethroplasty using a bovine pericardium graft: an experimental study using normal urethras from dogs

Lara

Lucon

Arap

2004

Braz J Med Biol Res

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The use of bovine pericardium as a urethral patch to substitute a ventral segment of canine urethras was studied. Healing, epithelial growth, urethral permeability, fistulas, and calcification were analyzed. Thirty male mongrel dogs of medium and large size underwent resection of a ventral segment of the medial urethra measuring 2.0 x 0.5 cm, which was replaced with a bovine pericardium graft, treated with buffered glutaraldehyde and preserved in formaldehyde. Two running sutures of polygalactin 5-0 were applied, one on each side of the patch. The corpus spongiosum was closed with uninterrupted suture and the skin with interrupted suture of polygalactin 5-0. Six months later, the animals were examined and sacrificed under anesthesia. Retrograde urethrograms showed that the urethral healing was complete in six of the 30 animals, without stenosis, fistulas or dilations. Microscopic examination showed complete epithelization of these six urethras. The remaining 24 animals presented urethrocutaneous fistulas without stenosis, demonstrated by urethral catheterism using a 10-Fr plastic catheter. These data show that a successful urethral reconstruction of the penile urethra was possible in only 20% of the operated animals. Infection and leakage may be the cause of the urethrocutaneous fistulas present in 80% of cases. Further studies are necessary to determine whether such fistulas are avoidable. If they are, the bovine pericardium may well be an option in the treatment of urethral lesions in dogs.

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Section: Discussionmentioning

confidence: 99%

“…The question of bladder muscle regeneration is controversial. Several reports have shown incomplete muscle regeneration (30,32,33), while others have found no regeneration (29,31).…”

Section: Discussionmentioning

confidence: 99%

Urethroplasty using a bovine pericardium graft: an experimental study using normal urethras from dogs

Lara

Lucon

Arap

2004

Braz J Med Biol Res

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“…O enxerto serviu como substrato para a migração do tecido vesical (Kambic et al, 1992), mas a presença de resquícios do tecido implantado mostra que a regeneração não foi completa aos 60 dias.…”

Section: A B C Dunclassified

“…As membranas biológicas, como bexiga homóloga (Baiotto, 2001;Oliveira, 1999), pericárdio bovino (Kambic et al, 1992), placenta de humanos (Fishman et al, 1987) e submucosa de bexiga (Yoo et al, 1998), foram testadas na reconstrução da bexiga de cães com resultados variados e, às vezes, conflitantes.…”

Section: Introductionunclassified

Avaliação clínica e histopatológica de alo-transplante de bexiga em cães

Teixeira

Rezende²,

Júnior

et al. 2007

Arq. Bras. Med. Vet. Zootec.

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RESUMOTestou-se a hipótese de o alo-transplante de bexiga devolver a capacidade estrutural e funcional desse órgão, usando-se 10 cães machos, saudáveis, submetidos à cistectomia parcial com preservação do trígono vesical. Utilizou-se o alo-transplante na reconstrução da vesícula urinária com acompanhamento dos animais durante 60 dias. Aos oito dias de pós-operatório, os cães apresentavam capacidade de contenção urinária e micção espontânea. Houve aumento gradativo do volume da vesícula urinária, alcançando, aos 60 dias, valores significativamente mais altos que os observados antes da cirurgia. Verificou-se integração tecidual com regeneração parcial na interface do transplante, caracterizada por reconstituição epitelial, proliferação fibroblástica, neoangiogênese e surgimento de fibras musculares lisas, aos 60 dias. Problemas como rejeição e obstrução uretral ocorreram em três cães. Conclui-se que o alo-transplante de bexiga em cães é viável e devolve a capacidade de repleção e as demais funções fisiológicas da vesícula urinária, ocorrendo regeneração parcial dos tecidos aos 60 dias de pós-operatório. Palavras-chave: cão, alo-transplante, bexiga ABSTRACT The hypothesis that urinary bladder allotransplant in dogs repairs

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“…Packaged material such as Dacron or GoreTex is available, and while they have been successfully used to cover penile prostheses, their use in nonprosthetic cases should be avoided because they are inelastic. Processed human cadaveric allograft skin has been used for penile reconstructive procedures, 19 biodegradable acetic acid and acetic anhydride treated pericardium has been used for experimental bladder augmentation, 20 and chemically processed and gamma irradiated cadaveric pericardium has been used in Peyronie's disease. 21 It remains to be seen, however, whether their use as tunica albuginea substitutes may prove less than satisfactory because of resorbtion and replacement by ®brous tissue.…”

Section: Peyronie's Disease Surgerymentioning

confidence: 99%

Future considerations: advances in the surgical management of erectile dysfunction

Angermeier

2000

Int J Impot Res

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As treatment options for erectile dysfunction (ED) continue to expand, and with more attractive alternatives such as effective systemic treatment becoming available, the number of men presenting for treatment of ED is increasing exponentially. Since a subset of these men continue to require surgical therapy, there is a potential for the number of operations for the treatment of ED and related disorders to actually increase. Areas in the surgical treatment of ED where improvements are needed are identi®ed, including: measures to prevent penile prosthesis infections, better penile implants, improved penile augmentation procedures, better surgical procedures for the treatment of Peyronie's disease, improved penile revascularization procedures, and new motor and sensory penile nerve grafting procedures.

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Biodegradable Pericardial Implants for Bladder Augmentation: A 2.5-Year Study in Dogs

Cited by 80 publications

References 18 publications

Urethroplasty using a bovine pericardium graft: an experimental study using normal urethras from dogs

Urethroplasty using a bovine pericardium graft: an experimental study using normal urethras from dogs

Avaliação clínica e histopatológica de alo-transplante de bexiga em cães

Future considerations: advances in the surgical management of erectile dysfunction

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